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61.
Remote-sensing satellite data are routinely used during disasters for damage assessment and to coordinate relief operations. Although there is a plethora of satellite sensors able to provide actionable data about an event, their temporal resolution is limited by their revisit time, presence of clouds, and errors in the reception of data. These limitations do not allow for an uninterrupted monitoring, which is crucial during disasters and emergencies. This research presents an approach that leverages the increased temporal resolution of crowdsourced data to partially overcome the limitations of satellite data. The proposed approach focuses on the geostatistical analysis of a combined satellite and Twitter data to help delineate the flood extent on a daily basis. The crowdsourced data are used to augment satellite imagery from Advanced Land Imager instrument on Earth Observating One (EO-1) satellite, Landsat 8, WorldView-2, and WorldView-3. The proposed methodology was applied to estimate the daily flood extents in Charleston, South Carolina, caused by the October 2015 North American storm complex. The results of the proposed methodology indicate that the user-generated data can be utilized adequately to both bridge the temporal gaps in the satellite-based observations and also increase the spatial resolution of the flood extents.  相似文献   
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National policies may have heterogeneous effects at the regional level. When coming to programmes aimed at increasing human capital, worker mobility from poorer to richer regions can reduce the benefits of the policy for the former areas. We focus on Italy and estimate the impact of education on the probability of migrating from a lagging area to a leading one. Endogeneity is addressed by exploiting an increase in the minimum school-leaving age in an instrumental variable framework. We find that one additional year of education increases the probability to migrate by 1.7 percentage points (9% of the average migration rate).  相似文献   
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The potentialities of PEEK-WC (thermally treated at 120 °C) and PLA polymers have been studied in the field of membrane technology applied to H2 separation/purification. In particular, for low/medium temperature operation (80 °C), PEEK-WC membranes (66 μm thick) showed good results in terms of H2/CH4 separation, showing an ideal selectivity value higher than 40. Meanwhile, we observed interesting selectivity also for H2/N2 and H2/CO2 separation, reaching values of 24 and 20, respectively. As expected, for PEEK-WC thermally treated membranes, the H2 permeating flux increased from 25 to 80 °C and by increasing the transmembrane pressure. Furthermore, H2 permeability at 80 °C was around 20 barrer. Concerning PLA membranes (26 μm thick), it is worth of noting that this polymer was pioneeristically used in this work as membrane application, showing great results in terms of H2/CO2 separation. Indeed, we overcame the Robeson's upper-bound (2008), achieving an ideal selectivity H2/CO2 around 25 with an H2 permeability of 25 barrer. Further advantage due to the utilization of PLA membranes was related to the temperature operations set at ambient conditions, constituting a valuable and cost-effective solution for H2/CO2 separation processes via polymeric membrane technology.  相似文献   
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Background: Autophagy is a highly conserved catabolic homeostatic process, crucial for cell survival. It has been shown that autophagy can modulate different cardiovascular pathologies, including vascular calcification (VCN). Objective: To assess how modulation of autophagy, either through induction or inhibition, affects vascular and valvular calcification and to determine the therapeutic applicability of inducing autophagy. Data sources: A systematic review of English language articles using MEDLINE/PubMed, Web of Science (WoS) and the Cochrane library. The search terms included autophagy, autolysosome, mitophagy, endoplasmic reticulum (ER)-phagy, lysosomal, calcification and calcinosis. Study characteristics: Thirty-seven articles were selected based on pre-defined eligibility criteria. Thirty-three studies (89%) studied vascular smooth muscle cell (VSMC) calcification of which 27 (82%) studies investigated autophagy and six (18%) studies lysosomal function in VCN. Four studies (11%) studied aortic valve calcification (AVCN). Thirty-four studies were published in the time period 2015–2020 (92%). Conclusion: There is compelling evidence that both autophagy and lysosomal function are critical regulators of VCN, which opens new perspectives for treatment strategies. However, there are still challenges to overcome, such as the development of more selective pharmacological agents and standardization of methods to measure autophagic flux.  相似文献   
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A comprehensive computational fluid dynamic model has been developed using COMSOL Multiphysics 5.4 software to predict the behavior of a membrane reactor in dehydrogenation of methylcyclohexane for hydrogen production. A reliable reaction kinetic of dehydrogenation reaction and a permeation mechanism of hydrogen through silica membrane have been used in computational fluid dynamic modeling. For performance comparison, an equivalent traditional fixed bed reactor without hydrogen removal has been also modeled. After model validation, it has been used to evaluate the operating parameters effect on the performance of both the silica membrane reactor and the equivalent traditional reactor as well. The operating temperature ranged between 473 and 553 K, pressure between 1 and 2.5 bar, sweep factor from ?6.22 to 25 and feed flow rate from 1 to 5 × 10?6 mol/s. The membrane reactor performed better than the equivalent traditional reactor, achieving as best result complete methylcyclohexane conversion and 96% hydrogen recovery.  相似文献   
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