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51.
Valentina Aina Gianluca Malavasi Claudio Magistris Giuseppina Cerrato Gianmario Martra Guido Viscardi Ledi Menabue Gigliola Lusvardi 《Journal of materials science. Materials in medicine》2014,25(10):2243-2253
Bioceramics, such as silica-based glasses, are widely used in bone and teeth restoration. Nowadays, the association between nanotechnology and pharmacology is one of the most promising research fields in cancer therapy. The advanced processing methods and new chemical strategies allow the incorporation of drugs within them or on their functionalized surfaces. Bioceramics can act as local drug delivery systems to treat bone and teeth diseases. The present paper reports data related to the development of a pH-stimuli responsive bioactive glass. The glass conjugation with 5-aminofluorescein (5-AF), through a pH-sensitive organic spacer, allows to produce a pH-responsive bioactive biomaterial: when it is exposed to specific pH changes, it can favour the release of 5-AF directly at the target site. 5-AF has been chosen as a simple, low cost, non toxic model to simulate doxorubicin, an anticancer drug. As doxorubicin, 5-AF contains an amino group in its structure in order to form an amide bond with the carboxylic functionalities of the glass. Raman spectroscopy and thermal analysis confirm the glass conjugation of 5-AF by means of an amide bond; the amount of 5-AF loaded was very high (≈65 and 44 wt%). The release tests at two different pH (4.2 and 7.4) show that the amount of released 5-AF is higher at acid pH with respect to physiological one. This preliminary datum evidenced that a pH-sensitive drug delivery system has been developed. The low amount of 5-AF released (<1 wt% of the total 5-AF) is due to the very low solubility of 5-AF in aqueous medium. This disadvantage, may be overcome in a dynamic environment (physiological conditions), where it is possible to obtain a drug release system ensuring an effective therapeutic dose for long times and, at the same time, avoiding the drug toxicity. 相似文献
52.
Dr. Ralf Bandorf Stefan Waschke Dr. Michael Vergöhl Prof. Dr.‐Ing. Guido Grundmeier Prof. Dr. Günter Bräuer 《真空研究与实践》2015,27(4):18-23
Direct metallization of plastics by high powerimpulse magnetron sputtering Even if polymers are today industrially used for decades the direct metallization of plastics is still a hot topic for research and development. Especially in light of the ban of hexavalent chromium an increasing demand for well‐adhering plastic metallization arises. High power impulse magnetron sputtering HIPIMS is a recent technology that can offer a high potential for successfully solving this challenge. This article focuses on the direct metallization of plastics by HIPIMS. In the frame of the investigations any pretreatment was ignored and the different polymers were directly under vacuum metallized. Compared to conventional mid‐frequency sputtering a significant improvement in adhesion was shown for different polymers. In detail the metallization of Plexiglas (PMMA) was investigated, since this polymer is highly challenging with respect to plasma processes. Due to the UV radiation damage of PMMA during plasma deposition direct metallization is usually not possible. Using ionized deposition it was possible to directly metallize the substrates with excellent adhering films without any interface layers or special pretreatments. The characterization of the substrate‐coating interface showed that for the well adhering films a cohesive fracture, i.e. a fracture within the polymer occurred. 相似文献
53.
The concepts of both duality and fuzzy uncertainty in linear programming have been theoretically analyzed and comprehensively and practically applied in an abundance of cases. Consequently, their joint application is highly appealing for both scholars and practitioners. However, the literature contributions on duality in fuzzy linear programming (FLP) are neither complete nor consistent. For example, there are no consistent concepts of weak duality and strong duality. The contributions of this survey are (1) to provide the first comprehensive overview of literature results on duality in FLP, (2) to analyze these results in terms of research gaps in FLP duality theory, and (3) to show avenues for further research. We systematically analyze duality in fuzzy linear programming along potential fuzzifications of linear programs (fuzzy classes) and along fuzzy order operators. Our results show that research on FLP duality is fragmented along both dimensions; more specifically, duality approaches and related results vary in terms of homogeneity, completeness, consistency with crisp duality, and complexity. Fuzzy linear programming is still far away from a unifying theory as we know it from crisp linear programming. We suggest further research directions, including the suggestion of comprehensive duality theories for specific fuzzy classes while dispensing with restrictive mathematical assumptions, the development of consistent duality theories for specific fuzzy order operators, and the proposition of a unifying fuzzy duality theory. 相似文献
54.
ABSTRACTThis paper explores the case of the historic harbour area of Naples, considered highly significant, due to its physical and cultural characteristics, with the aim of reflecting on the contemporary need for building renewed and synergic city–port relations in a sustainable perspective. Focusing on the physical and functional city–port integration, the study investigates Naples harbour planning policy between twentieth and twenty-first centuries in order to identify the limitations of older instruments and to exam the current proposal, finally suggesting perspectives for the future. The analysis highlights the fact that, in the port of Naples, with a landlord governance, the main obstacles to a more inclusive planning policy have been related to land use conflict between on one hand the public interest of the Port Authority and Municipality and the private interest of port operators on the other. In conclusion, the need for city–port plan integration is outlined as a central planning issue so as to combine the economic development of the harbour with social, cultural and ecological themes and to overcome the conflicts between the different actors involved in the complex planning process. 相似文献
55.
Guido C Galletti Paola Bocchini Ana M Smacchia James B Reeves III 《Journal of the science of food and agriculture》1996,71(1):1-9
Maize stovers collected every 14 days over an 84-day growth period were subjected to high-performance liquid chromatography with electrochemical detector (HPLC-ED) and pyrolysis/gas chromatography/mass spectrometry (PY/GC/MS) in order to monitor changes in the phenolic composition. Prior to HPLC-ED analyses, ground samples were sequentially extracted with (i) methanol, (ii) 0·1M sodium hydroxide and (iii) 2M sodium hydroxide in the presence of nitrobenzene to separate, respectively, free phenolic monomers, alkali-labile phenolic monomers and alkali-resistant lignin. In turn, solution (ii) was treated with alkaline nitrobenzene to obtain (iv) alkali-labile lignin. Pyrolysis was carried out on ground native samples by using a platinum heated filament pyrolyser. Increases in the absolute phenolic concentrations in the residues of 0·1M sodium hydroxide extraction and in the ratio of alkali-resistant lignin vs total lignin were observed by HPLC-ED during the first 28–42 days of maturation, reaching a steady level in the remaining maturation period. A linear increase of syringyl units vs guaiacyl units was for found the alkali-resistant lignin fraction over the entire period of maturation. Similar trends were showed by PY/GC/MS with regard to relative lignin content and syringyl/guaiacyl ratio. Both techniques showed their usefulness to gauge changes in the phenolic composition during the lignification process. 相似文献
56.
Tama Dinur Peter Bauer Christian Beetz Guido Kramp Claudia Cozma Marius-Ionu Iuracu Michal Becker-Cohen Majdolen Istaiti Arndt Rolfs Ari Zimran Shoshana Revel-Vilk 《International journal of molecular sciences》2022,23(3)
For years, the gold standard for diagnosing Gaucher disease (GD) has been detecting reduced β-glucocerebrosidase (GCase) activity in peripheral blood cells combined with GBA1 mutation analysis. The use of dried blood spot (DBS) specimens offers many advantages, including easy collection, the need for a small amount of blood, and simpler transportation. However, DBS has limitations for measuring GCase activity. In this paper, we recount our cross-sectional study and publish seven years of experience using DBS samples and levels of the deacylated form of glucocerebroside, glucosylsphingosine (lyso-Gb1), for GD diagnosis. Of 444 screened subjects, 99 (22.3%) were diagnosed with GD at a median (range) age of 21 (1–78) years. Lyso-Gb levels for genetically confirmed GD patients vs. subjects negative to GD diagnosis were 252 (9–1340) ng/mL and 5.4 (1.5–16) ng/mL, respectively. Patients diagnosed with GD1 and mild GBA1 variants had lower median (range) lyso-Gb1, 194 (9–1050), compared to GD1 and severe GBA1 variants, 447 (38–1340) ng/mL, and neuronopathic GD, 325 (116–1270) ng/mL (p = 0.001). Subjects with heterozygous GBA1 variants (carrier) had higher lyso-Gb1 levels, 5.8 (2.5–15.3) ng/mL, compared to wild-type GBA1, 4.9 (1.5–16), ng/mL (p = 0.001). Lyso-Gb1 levels, median (range), were 5 (2.7–10.7) in heterozygous GBA1 carriers with Parkinson’s disease (PD), similar to lyso-Gb1 levels in subjects without PD. We call for a paradigm change for the diagnosis of GD based on lyso-Gb1 measurements and confirmatory GBA1 mutation analyses in DBS. Lyso-Gb1 levels could not be used to differentiate between heterozygous GBA1 carriers and wild type. 相似文献
57.
Viliame Savou Guido Grause Shogo Kumagai Yuko Saito Tomohito Kameda Toshiaki Yoshioka 《能源学会志》2019,92(4):1149-1157
Pyrolysis is a promising technique for the recovery of useful gas, tar, and solid products from biomass waste. However, the low tar yields obtained from lignocellulosic biomass are a significant drawback. To enhance tar yields, sugarcane bagasse, which is the most abundant agricultural waste in Fiji, was pretreated at ambient temperature and atmospheric pressure using various sulfuric acid (H2SO4) concentrations. Here, the ether bonds of cellulose, hemicellulose, and lignin were partially hydrolyzed. The pretreated samples were then pyrolyzed at 500 °C, and it was confirmed that H2SO4-pretreatment disrupted the bagasse cell structure, with the thermogravimetry and differential thermogravimetry results confirming that decomposition occurred at lower temperatures after pretreatment. In addition, tar yields were significantly enhanced from 5.6 wt% to 13.4 wt% for the untreated and 3 M H2SO4-pretreated samples respectively. The main components detected in this tar product were levoglucosan, andcellulose-and hemicellulose-derived products, whose proportions were increased following pretreatment. Thus, our work demonstrates that dilute acid pretreatment enhances tar production from sugarcane bagasse due to the production of shorter chain components via the partial hydrolysis of ether bonds. 相似文献
58.
59.
Isabel Pagani Pietro Demela Silvia Ghezzi Elisa Vicenzi Massimo Pizzato Guido Poli 《International journal of molecular sciences》2022,23(6)
In addition to CD4+ T lymphocytes, myeloid cells and, particularly, differentiated macrophages are targets of human immunodeficiency virus type-1 (HIV-1) infection via the interaction of gp120Env with CD4 and CCR5 or CXCR4. Both T cells and macrophages support virus replication, although with substantial differences. In contrast to activated CD4+ T lymphocytes, HIV-1 replication in macrophages occurs in nondividing cells and it is characterized by the virtual absence of cytopathicity both in vitro and in vivo. These general features should be considered in evaluating the role of cell-associated restriction factors aiming at preventing or curtailing virus replication in macrophages and T cells, particularly in the context of designing strategies to tackle the viral reservoir in infected individuals receiving combination antiretroviral therapy. In this regard, we will here also discuss a model of reversible HIV-1 latency in primary human macrophages and the role of host factors determining the restriction or reactivation of virus replication in these cells. 相似文献
60.
Important environmental parameters in arctic periglacial landscapes (i.e. permafrost temperature, active-layer depth, soil moisture, precipitation, vegetation cover) will very likely change in a warming climate. The thawing of permafrost, especially, might cause massive landscape changes due to thermokarst and an enhanced release of greenhouse gasses from the large amounts of carbon stored in frozen deposits, resulting in positive climate-warming feedback. For the identification, mapping, and quantification of such changes on various scales up to the entire circum-Arctic, remote sensing and spatial data analysis are essential tools. In this study an extensive field-work dataset including spectral surface properties, vegetation, soils, and geomorphology was acquired in the largest Arctic delta formed by a single river, the Siberian Lena River Delta. A portable field spectrometer (ASD FieldSpec Pro FR®) was used for spectral surveys of terrain surfaces, and optical satellite data (Landsat Enhanced Thematic Mapper (ETM+), CHRIS-Proba) were used for the characterization, manual mapping, and automatic classification of typical periglacial land-cover units in the Lena Delta. Qualitative data from soils, vegetation, soil moisture, and relief units were correlated with the field-spectral data and catalogued for a wide variety of surface types. The wide range of micro- and meso-scale variations of periglacial surface features in the delta results in distinctive spectral characteristics for different land-cover units. The three main delta terraces could also be spectrally separated and characterized. The present dataset provides a basis for further spectral data acquisitions in the Lena Delta and for comparisons with periglacial surfaces from other regions. 相似文献