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31.
Operational transfer path analysis 总被引:2,自引:0,他引:2
Gert De Sitter Christof Devriendt Patrick Guillaume Erik Pruyt 《Mechanical Systems and Signal Processing》2010,24(2):416-431
One of the tools used to study the NVH behaviour of a system is the transfer path analysis. It aims to identify the operational forces and the propagation paths of the vibrations and is especially interesting in the case when the system is composed of different subsystems. The classical techniques identify the transfer paths when the system is disassembled. This way one eliminates flanking transfer paths. Yet it is very time-consuming and the boundary conditions are not correct anymore. The presented method makes it possible to identify the transfer paths without disassembling the system. The advantages are that the overall testing time is reduced and that the real boundary conditions are present. In this article the theory will be reviewed and it will be validated using data generated by finite element simulations. 相似文献
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Guillaume Fromentin Gérard Poulachon 《The International Journal of Advanced Manufacturing Technology》2010,49(1-4):81-87
Thread milling offers interesting possibilities for machining internal or external threads. This machining technique uses a mill with a triangular profile for metric threads and a helical interpolation strategy. Thus, the uncut chip thickness cannot be easily evaluated from a simplified approach. The present study deals with a model for calculating uncut chip thickness during internal thread milling. This step is needed to understand and model the cutting forces. The model developed uses the geometrical definitions of the mill and takes into account the milling mode and the cutting conditions. The link with the interferences between the tool and the thread is also established and corroborates a previous study. A full analytical formulation of the problem is proposed, and results from different milling settings are presented. 相似文献
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Bulky End‐Capped [1]Benzothieno[3,2‐b]benzothiophenes: Reaching High‐Mobility Organic Semiconductors by Fine Tuning of the Crystalline Solid‐State Order 下载免费PDF全文
Guillaume Schweicher Vincent Lemaur Claude Niebel Christian Ruzié Ying Diao Osamu Goto Wen‐Ya Lee Yeongin Kim Jean‐Baptiste Arlin Jolanta Karpinska Alan R. Kennedy Sean R. Parkin Yoann Olivier Stefan C. B. Mannsfeld Jérôme Cornil Yves H. Geerts Zhenan Bao 《Advanced materials (Deerfield Beach, Fla.)》2015,27(19):3066-3072
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Jerome Kluza Victoriane Peugnet Blanche Daunou William Laine Gwenola Kervoaze Gaëlle Rmy Anne Loyens Patrice Maboudou Quentin Fovez Corinne Grangette Isabelle Wolowczuk Philippe Gosset Guillaume Garon Philippe Marchetti Florence Pinet Muriel Pichavant Emilie Dubois-Deruy 《International journal of molecular sciences》2022,23(1)
Mitochondrial dysfunctions are implicated in several pathologies, such as metabolic, cardiovascular, respiratory, and neurological diseases, as well as in cancer and aging. These metabolic alterations are usually assessed in human or murine samples by mitochondrial respiratory chain enzymatic assays, by measuring the oxygen consumption of intact mitochondria isolated from tissues, or from cells obtained after physical or enzymatic disruption of the tissues. However, these methodologies do not maintain tissue multicellular organization and cell-cell interactions, known to influence mitochondrial metabolism. Here, we develop an optimal model to measure mitochondrial oxygen consumption in heart and lung tissue samples using the XF24 Extracellular Flux Analyzer (Seahorse) and discuss the advantages and limitations of this technological approach. Our results demonstrate that tissue organization, as well as mitochondrial ultrastructure and respiratory function, are preserved in heart and lung tissues freshly processed or after overnight conservation at 4 °C. Using this method, we confirmed the repeatedly reported obesity-associated mitochondrial dysfunction in the heart and extended it to the lungs. We set up and validated a new strategy to optimally assess mitochondrial function in murine tissues. As such, this method is of great potential interest for monitoring mitochondrial function in cohort samples. 相似文献
35.
Ccile Coudy-Gandilhon Marine Gueugneau Christophe Chambon Daniel Taillandier Lydie Combaret Ccile Polge Guillaume Y. Millet Lonard Fasson Daniel Bchet 《International journal of molecular sciences》2022,23(7)
Middle-aged and master endurance athletes exhibit similar physical performance and long-term muscle adaptation to aerobic exercise. Nevertheless, we hypothesized that the short-term plasticity of the skeletal muscle might be distinctly altered for master athletes when they are challenged by a single bout of prolonged moderate-intensity exercise. Six middle-aged (37Y) and five older (50Y) master highly-trained athletes performed a 24-h treadmill run (24TR). Vastus lateralis muscle biopsies were collected before and after the run and assessed for proteomics, fiber morphometry, intramyocellular lipid droplets (LD), mitochondrial oxidative activity, extracellular matrix (ECM), and micro-vascularisation. Before 24TR, muscle fiber type morphometry, intramyocellular LD, oxidative activity, ECM and micro-vascularisation were similar between master and middle-aged runners. For 37Y runners, 24TR was associated with ECM thickening, increased capillary-to-fiber interface, and an 89% depletion of LD in type-I fibers. In contrast, for 50Y runners, 24TR did not alter ECM and capillarization and poorly depleted LDs. Moreover, an impaired succinate dehydrogenase activity and functional class scoring of proteomes suggested reduced oxidative phosphorylation post-24TR exclusively in 50Y muscle. Collectively, our data support that middle-aged and master endurance athletes exhibit distinct transient plasticity in response to a single bout of ultra-endurance exercise, which may constitute early signs of muscle aging for master athletes. 相似文献
36.
Guillaume Duflos Bruno Le Fur Veronique Mulak Philippe Becel Pierre Malle 《Journal of the science of food and agriculture》2002,82(12):1341-1345
Freezing is an efficient way of storing fish. Objectively though, it is very hard to determine whether a fish has been previously frozen. Following an appraisal of various methods, we selected a physical determination (torrymeter), a physiological examination (eye lens) and three enzymatic assays (α‐glucosidase, β‐N‐acetylglucosaminidase and β‐hydroxyacyl‐CoA‐dehydrogenase) and applied them to three species: plaice (Pleuronectes platessa), whiting (Merlangus merlangus) and mackerel (Scomber scombrus). We also compared the results obtained following slow and rapid freezing and investigated how spoilage affects the torrymeter measurements and α‐glucosidase assay values. For whole fish the physical method using the torrymeter is a reliable indicator. For fish fillets we recommend the enzymatic method using the α‐glucosidase assay, which should be accompanied by measurement of the freshness to avoid confusing a frozen–thawed fish and a fish in an advanced stage of spoilage. The values noted for fresh and thawed whiting and plaice indicated cut‐off values of 0.15 for whiting and 0.5 for plaice, above which it can be asserted that the sample had been frozen. © 2002 Society of Chemical Industry 相似文献
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Nielsen Guillaume Janin Amelie Coudert Lucie Blais Jean Francois Mercier Guy 《Mine Water and the Environment》2018,37(1):42-55
Mine Water and the Environment - Passive treatment is a promising, green technology that is increasingly being used for mine drainage treatment. However, several challenges remain concerning its... 相似文献
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