Managing Clinical Use of High-Alert Drugs: A Supervised Learning Approach to Pharmacokinetic Data Analysis

Drug-related problems, particularly those that result from sub- or overtherapeutic doses of high-alert medications, have become a growing concern in clinical medicine. In this paper, we use a model-tree-based regression technique (namely, M5) and support vector machine (SVM) for regression to develop learning-based systems for predicting the adequacy of a vancomycin regimen. We empirically evaluate each system's accuracy in predicting patients' peak and trough concentrations in different clinical scenarios characterized by renal functions and regimen types. Our data consist of 1099 clinical cases that were collected from a major tertiary medical center in southern Taiwan. We also examine the use of bagging for enhancing the prediction power of the respective systems and include in our evaluation a salient one-compartment model for performance benchmark purposes. Overall, our evaluation results suggest that both M5 and SVM are significantly more accurate than the benchmark one-compartment model in predicting patients' peak and trough concentrations across all investigated clinical scenarios. M5 appears to benefit considerably from bagging, which has a positive but seemingly smaller effect on SVM. Taken together, our findings indicate supervised learning techniques that are capable of effectively supporting clinicians' use of vancomycin or similar high-alert drugs in their patient care and management.     

控制W9Cr3Mo4V低倍碳化物剥落的工艺改进

针对W9Cr3M04V轧制成品材低倍碳化物剥落的形成原因分析，得出一次碳化物颗粒粗大、在1／4D至中心区域聚集是导致低倍热酸浸试验碳化物剥落的主因；由此进行冶炼过程中注速（锭形）、浇注温度选择对比工艺试验，得出在原有冶炼＋轧制的工艺基础上选用2．2t锭、降低浇注温度（1489℃）能有效改善一次碳化物颗粒大小和聚集程度，进而有效降低低倍碳化物剥落倾向。     

营造休闲空间

商店酒店．餐厅和酒吧是人们享受消费体验的场所．商业空间的设计需要抓住的是人们对这种体验过程的需求。营造不同的空间氛围可以吸引不同品位的类型的消费人群。在商店中商品不是顾客唯一寻求的东西．别致舒适的试衣间，通透明亮的镜子与室内环境的搭配甚至柜台提供的糖果都是购物者所需要的东西。同样餐厅的主角不一定是食物，精致的餐具同样可以吸引回头客的光顾．酒吧沙发上的靠垫：酒店大厅的天花板都可能是成为有价值的卖点：86期的《WALLPAPER》为我们挑选了来自世界流行消费场所．他们的卖点又在哪里呢？     

精对苯二甲酸反应器桨叶断裂分析与修复

为了保证进口精对苯二甲酸装置氧化反应器中钛制搅拌器的正常工作，对钛制搅拌器桨叶在运行中断裂脱落的原因进行了分析，并叙述了桨叶修理的方法和要求。经修理后的桨叶投入生产使用，达到了预期的目标。     

Synthesis of nonsharp distillation sequences via genetic programming

This paper addresses the application of Genetic Programming (GP) to the synthesis of multicomponent product nonsharp distillation sequences. Combined with the domain knowledge of chemical engineering, some evolutionary factors are improved, and a set of special encoding method and solving strategy is proposed to deal with this kind of problem. The system structural variable is optimized by GP and the continuous variable is optimized by the simulated annealing algorithm simultaneously. Because GP has an automatic searching function, the optimal solution can be found including distillation, splitting, blending and bypassing operations automatically without any superstructures of nonsharp distillation sequences. Three illustrative examples are presented to demonstrate the effective computational strategies.     

钢纤维聚合物混凝土抗压本构关系

钢纤维聚合物混凝土是由聚合物混凝土基体和钢纤维共同组成的纤维增强复合材料，它的力学行为不仅依赖于聚合物混凝土基体的行为，而且与钢纤维的掺量、分散特征以及钢纤维的几何尺寸有关，本文将基于损伤力学原理研究在不同纤维掺量下的钢纤维聚合物混凝土的全程压力-应变曲线及其本构模型。     

Electrochemical determination of estradiol using a poly(l-serine) film-modified electrode

A thin film of poly(l-serine) was prepared via electropolymerization for the determination of trace levels of estradiol. In pH 5.0 phosphate buffer, l-serine was oxidized during the cyclic potential sweeps between −0.60 and 2.0 V, forming a thin film at the electrode surface. The electrochemical behavior of estradiol was investigated. The oxidation peak potential of estradiol shifts negatively at the poly(l-serine) film-coated glassy carbon electrode (GCE) compared with that at the bare GCE. Otherwise, the oxidation peak current greatly increases at the poly(l-serine) film-modified GCE. These phenomena suggest that the poly(l-serine) film exhibits catalytic activity towards the electrochemical oxidation of estradiol. Based on this, a sensitive, rapid and simple electrochemical method was proposed for the determination of estradiol. The limit of detection is evaluated to be 2.0 × 10⁻⁸ mol L⁻¹. Finally, this method was successfully used to determine estradiol in blood serum.     

Application of ultrasonic waves in activation of microcrystalline cellulose

In this work, microcrystalline cellulose (MCC) was activated with ultrasonic waves. The influences of ultrasonic treatment on the changes of supramolecular structures and morphology structure were studied by WAXS and SEM. The accessibility of the MCC was characterized by water retention value (WRV) and specific surficial area. The influence of ultrasonic treatment on the reactivity of MCC was investigated through the reaction of MCC being oxidized into 2,3‐diadehyde cellulose (DAC) by periodate sodium. The mechanism of the reactivity change of ultrasonically treated MCC was examined. The results showed that the degree of crystallinity of MCC decreased and the degree of polymerization showed little change after treatment with ultrasonic waves. The morphologial variation of the treated MCC was significant when compared with the untreated MCC, which contribute to the improvement of accessibility. The aldehyde content of DAC prepared from ultrasonically treated MCC was improved from 64.19 to 85.00%, indicating that the regioselective oxidation reactivity of MCC was significantly improved. The aldehyde content was found to first increase with time of ultrasonic treatment to a point, and then decrease as time progressed. In addition, the aldehyde content was found to increase with an increase in ultrasonic power. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008     

Influence of post‐treatments on the properties of porous poly(vinyl alcohol) membranes

Porous poly(vinyl alcohol) (PVA) membranes were prepared by a phase‐inversion method. The influence of chemical crosslinking and heat treatments on the swelling degree, resistance to compaction, mechanical strength, and morphology of porous PVA membranes was extensively studied. The crosslinking degree and crystallinity of the membranes, calculated from IR spectra, increased with the treatment time. The porosity, calculated on the basis of swelling experiments, showed a decreasing trend for heat‐treated membranes but remained almost at a constant value for crosslinked membranes. Such a change was further proved with scanning electron microscopy pictures. The behavior was explained by the rearrangement of PVA chains during the heat‐treatment process, which led to morphological changes in the membranes. The mechanical properties of the porous membranes in dry and wet states were measured, and a great difference was observed between crosslinked and heat‐treated membranes in the dry and wet states. The crosslinked membranes showed good mechanical properties in the dry state but became fragile in the wet state. On the contrary, the heat‐treated membranes were more flexible in the wet state than in the dry state. This change was explained by the turnaround of inner stress in the systems during the swelling process. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008