Kommentar I

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Editorial

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On plastic potentials for anisotropic metals and their derivation from the texture function

Summary Plastic yielding of anisotropic metals can be either described by a macroscopic constitutive relation or assessed by means of a model which correlates single and polycrystal behaviors. The mathematical identification of the plastic work rate derived from the two approaches, for all strain rate tensors, leads to a fit of the polycrystal yield surface by an analytical function. When a quadratic from is assumed, the macroscopic anisotropy parameters become explicit functions of the texture coefficients. This identification method is applied to calculate yield surfaces andR-values of rolled and annealed steel sheets: theR-values and in general the flow rule, are more significantly modified by the fitting than the yield surface. Thus, it is worth extending the method to more general constitutive relations which may be given by the form of their work function: alternative forms of the work function for plastic materials are explored, especially in the bearing of convexity and homogeneity where quadratic forms have a distinct advantage. Finally, it is shown that the identification of the work function allows to express the phenomenological coefficients as analytical functions of the texture parameters for many forms of the work function; in the other cases, these coefficients may be obtained by linear or non-linear regression.     

The putative tumor suppressor gene on chromosome 5q for hepatocellular carcinoma is distinct from the MCC and APC genes

We have previously shown that the tumor suppressor gene for hepatocellular carcinoma (HCC) without cirrhosis may be located on chromosome 5q35-qter. In this study, we analyzed nine cases of primary HCC without cirrhosis using probes from the MCC and APC genes, which are in the region 5q21-22. None of the informative cases had allele loss detected by these probes, whereas the probe lambda MS8 for the region 5q35-qter showed allele loss in six out of six informative cases. The results confirm that the putative tumor suppressor gene for HCC without cirrhosis on chromosome 5q is distinct from the MCC and APC genes.     

QUEUE

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