Revealing determinants of two‐phase dynamics of P53 network under gamma irradiation based on a reduced 2D relaxation oscillator model

This study proposes a two‐dimensional (2D) oscillator model of p53 network, which is derived via reducing the multidimensional two‐phase dynamics model into a model of ataxia telangiectasia mutated (ATM) and Wip1 variables, and studies the impact of p53‐regulators on cell fate decision. First, the authors identify a 6D core oscillator module, then reduce this module into a 2D oscillator model while preserving the qualitative behaviours. The introduced 2D model is shown to be an excitable relaxation oscillator. This oscillator provides a mechanism that leads diverse modes underpinning cell fate, each corresponding to a cell state. To investigate the effects of p53 inhibitors and the intrinsic time delay of Wip1 on the characteristics of oscillations, they introduce also a delay differential equation version of the 2D oscillator. They observe that the suppression of p53 inhibitors decreases the amplitudes of p53 oscillation, though the suppression increases the sustained level of p53. They identify Wip1 and P53DINP1 as possible targets for cancer therapies considering their impact on the oscillator, supported by biological findings. They model some mutations as critical changes of the phase space characteristics. Possible cancer therapeutic strategies are then proposed for preventing these mutations’ effects using the phase space approach.Inspec keywords: physiological models, cellular biophysics, cancer, difference equations, delays, enzymes, biochemistry, molecular biophysics, gamma‐rays, radiation therapyOther keywords: two‐phase dynamics model, P53 network, gamma irradiation, 2D relaxation oscillator model, ATM model, Wip1 variables, p53‐regulators, cell fate decision, excitable relaxation oscillator, Wip1 time delay, state‐dependent delay differential equation, cell cycle arrest, cell apoptosis, cancer therapies, Wip1 overexpression, Wip1 downregulation, ATM deficiency, Mdm2 overexpression, Mdm2 downregulation, mutation effects, phase space approach     

Effect of magnetic field and temperature on the voltage-current characteristics of YBCO superconductor

Voltage-current characteristics of YBCO superconductor was studied under magnetic field up to 0.4 T at different temperatures below T_c. The critical temperature decreases and the transition width broadens under magnetic field. V-I data below T_c were fitted to a power law expression V I^(T,B) in which (T,B) is found to decrease with increase of magnetic field and temperature, gradually approaching unity as T approaches T_c, being independent of magnetic field. Similarly, (T,B) approaches unity as magnetic field increases being independent of temperature.     

The axisymmetric crack problem in a non-homogeneous interfacial region between homogeneous half-spaces

In this paper, the axisymmetric crack problem in a non-homogeneous interfacial region between two homogeneous half-spaces is considered. It is assumed that the shear modulus varies continuously between that of the two half-spaces; and the shear modulus for the interface region is approximated by = ₀ e^mz. By using Hankel transform technique the problem is reduced to a pair of singular integral equations. The solutions of the problem are obtained for different material combinations and loading conditions; and modes I and II stress intensity factors, and the direction of a probable crack growth are calculated.     

Approximation by Stancu–Chlodowsky polynomials

In this paper, we investigate convergence and approximation properties of a Chlodowsky type generalization of Stancu polynomials (we called Stancu–Chlodowsky polynomials).The rates of convergence of this generalization are obtained by means of modulus of continuity and by using the $K$-functional of Peetre. We also present and prove theorems on weighted approximation and the order of approximation of continuous functions by these operators on all positive semi-axis.     

Schauder bases and approximation property in fuzzy normed spaces

Our aim in this article is to introduce and study the notion of weak and strong Schauder bases in fuzzy normed spaces. Further, we introduce strong and weak fuzzy approximation properties and set a relationship between these two new notions which may provide an acceleration to the structural analysis of fuzzy normed spaces.     

Bandwidth-effective streaming of educational medical videos

Real-time delivery of medical videos requires high level of quality of service that shows no tolerance to loss and delay. In this study, how content-adaptive streaming can aid to maintain high-quality streaming sessions is investigated. The proposed strategy allocates a specific amount of bandwidth to streaming sessions and takes advantage of the general structure of instructional medical videos to decrease bandwidth consumption below this limit. The main contribution of the proposed mechanism is that it eliminates the need for rate adaptation which is common in traditional streaming by employing a proper bandwidth management scheme that enables constant bandwidth consumption below the allocated capacity. A streaming system based on the proposed mechanism has been implemented and its performance has been tested via emulation. Experimental results indicate that content-adaptive streaming successfully eliminates the need of rate adaptation during the delivery of critical data and hence preserves viewers’ satisfaction.     

Multiobjective evolutionary clustering of Web user sessions: a case study in Web page recommendation

In this study, we experiment with several multiobjective evolutionary algorithms to determine a suitable approach for clustering Web user sessions, which consist of sequences of Web pages visited by the users. Our experimental results show that the multiobjective evolutionary algorithm-based approaches are successful for sequence clustering. We look at a commonly used cluster validity index to verify our findings. The results for this index indicate that the clustering solutions are of high quality. As a case study, the obtained clusters are then used in a Web recommender system for representing usage patterns. As a result of the experiments, we see that these approaches can successfully be applied for generating clustering solutions that lead to a high recommendation accuracy in the recommender model we used in this paper.     

Pseudo Bond Graph modelling and on-line estimation of unknown kinetics for a wastewater biodegradation process

This paper deals with the problem of modelling and on-line estimation of kinetics for a biomethanation process. This bioprocess is in fact a wastewater biodegradation process with production of methane gas, which takes place inside a Continuous Stirred Tank Bioreactor. The reaction scheme and the analysis of biochemical phenomena inside the bioreactor are used in order to obtain a nonlinear dynamic model of the bioprocess, by means of the pseudo Bond Graph method. Two nonlinear estimation strategies are developed for the identification of unknown kinetics of the bioprocess. First, an estimator is developed by using a state observer based technique. Second, an observer based on high-gain approach is designed and implemented. Several numerical simulations are performed in order to analyse and compare the behaviour and the performance of the proposed estimators.     

Derivation of empirical equations for neutronic performance in a thorium fusion breeder with various coolants using regression analysis

In this paper, regression analyses (RA) are presented for the neutronic calculation of ThO₂ mixed ²⁴⁴CmO₂ fuel with different neutronic parameters for various coolants, natural lithium, Li₂₀Sn₈₀ and Flinabe, respectively. The tritium breeding ratio (TBR), energy multiplication factor (M), total fission rate (Σ_f) and ²³²Th(n, γ) reaction is computed by XSDRNPM. In addition, this numerical results are estimated by RA depends on neutronic parameters and the empirical equations for neutronic performance are acquired. The results obtained by using XSDRNPM and the results of the RA, obtained empirical equations, are compared. The empirical equations indicate that RA can successfully be used for the prediction of the neutronic performance parameters in the hybrid reactor with a high degree of accuracy. In addition, correlation matrix is calculated to determined statistical relationships between variables TBR, M, Σ_f, and ²³²Th(n, γ).     

An interactive whiteboard student survey: Development,validity and reliability

The interactive whiteboard (IWB) has become a popular technology for instructors over the last decade. Though research asserts that the IWBs facilitate learning in different ways, there is a lack of studies examining actual IWB use in classroom settings based on learners’ perspectives by means of valid instruments. The purpose of this study is to develop a valid and reliable interactive whiteboard student survey in order to evaluate the IWB use based on perceptions of students who have been taught with IWBs. In establishing the theoretical base of the survey, the Technology Acceptance Model (TAM) and constructivist learning theories were considered. In addition, with respect to IWB use in classrooms, a number of studies emanated from countries such as the UK, the USA, and Australia were examined, and similar research questionnaires and findings and also reflections of students about IWBs were utilized to create an item pool. A 39-item survey was conducted among middle school students (N = 263) from the city of Istanbul in Turkey. Collected data was exposed to exploratory factor analysis and resulted in a 26-item, three-factor survey, whose factors were named as the perceived efficiency of IWB, perceived learning contribution and motivation, and the perceived negative effects of IWB. The results of the analyses illustrated that this new IWB student scale, which explains 50% of the total variance with a good level of Cronbach’s Alpha coefficient (0.93) is a valid and reliable instrument designed specifically for measuring the use of IWBs in real classroom settings. Besides, theoretical foundations of interactive whiteboard use, the development process of the instrument, and results of validity and reliability analyses were discussed in detail.