Inspection Policies for A System which Is Inoperative During Inspection Periods

Inspection policy models deal with stochastically failing systems in which failures are detected by inspections only. In this paper we examine a model for a system which is inoperative during the inspection periods. This problem is important in situations where inspections demand a considerable amount of time, such as the inspection of production machines, inspection of communication systems, aircraft maintenance, etc. The costs incurred include the cost of inspections, the cost per time unit of unobserved breakdowns, and the cost of repairing (or replacing) the failed system. The objective is to minimize the expected total cost per time unit. Minimization of the system's unavailability is obtained as a special case by appropriate substitutions.     

Optimization of biodegradable sponges as controlled release drug matrices. I. Effect of moisture level on chitosan sponge mechanical properties

Cross-linked chitosan sponges as controlled release drug carrier systems were developed. Tramadol hydrochloride, a centrally acting analgesic, was used as a model drug. The sponges were prepared by freeze-drying 1.25% and 2.5% (w/w) high and low M.wt. chitosan solutions, respectively, using glutaraldehyde as a cross-linking agent. The hardness of the prepared sponges was a function of glutaraldehyde concentration and volume where the optimum concentration that offered accepted sponge consistency was 5%. Below or above 5%, very soft or very hard and brittle sponges were obtained, respectively. The determined drug content in the prepared sponges was uniform and did not deviate markedly from the calculated amount. Scanning electron microscopy (SEM) was used to characterize the internal structures of the sponges. The SEM photos revealed that cross-linked high M.wt. chitosan sponges have larger size surface pores that form connections (channels) with the interior of the sponge than cross-linked low M.wt. ones. Moreover, crystals of the incorporated Tramadol hydrochloride were detected on the lamellae and within pores in both chitosan sponges. Differences in pore size and dissolution medium uptake capacity were crucial factors for the more delayed drug release from cross-linked low M.wt. chitosan sponges over high M.wt. ones at pH 7.4. Kinetic analysis of the release data using linear regression followed the Higuchi diffusion model over 12 hours. Setting storage conditions at room temperature under 80-92% relative humidity resulted in soft, elastic, and compressible sponges.     

Using a distributed quadtree index in peer-to-peer networks

Peer-to-peer (P2P) networks have become a powerful means for online data exchange. Currently, users are primarily utilizing these networks to perform exact-match queries and retrieve complete files. However, future more data intensive applications, such as P2P auction networks, P2P job-search networks, P2P multiplayer games, will require the capability to respond to more complex queries such as range queries involving numerous data types including those that have a spatial component. In this paper, a distributed quadtree index that adapts the MX-CIF quadtree is described that enables more powerful accesses to data in P2P networks. This index has been implemented for various prototype P2P applications and results of experiments are presented. Our index is easy to use, scalable, and exhibits good load-balancing properties. Similar indices can be constructed for various multidimensional data types with both spatial and non-spatial components.     

Effect of combining Al,Mg, Ce or La oxides to extracted rice husk nanosilica on the catalytic performance of NiO during COx-free hydrogen production via methane decomposition

Amorphous nanosilica powder was extracted from rice husk and used as a catalyst support as well as a starting material for the preparation of different binary oxides, i.e., SiO₂Al₂O₃, SiO₂MgO, SiO₂CeO₂ and SiO₂La₂O₃. A series of supported nickel catalysts with the metal loading of 50 wt % were prepared by wet impregnation method and evaluated in methane decomposition to “CO_x-free” hydrogen production. The fresh and spent catalysts were extensively characterized by different techniques. Among the evaluated catalysts, both Ni/SiO₂Al₂O₃ and Ni/SiO₂La₂O₃ catalysts were the most active with an over-all H₂ yield of ca. 80% at the initial period of the reaction. This distinguishable higher catalytic activity is mainly referred to the presence of free mobile surface NiO and/or that NiO fraction weakly interacted with the support easily reducible at low temperatures. The Ni/SiO₂CeO₂ catalyst has proven a great potential for application in the hydrogen production in terms of its catalytic stability. The formation of Mg_xNi_(1?x)O solid solution caused the Ni/SiO₂MgO catalyst to lose its activity and stability at a long reaction time. Various types of carbon materials were formed on the catalyst surface depending on the type of support used. TEM images of as-deposited carbon showed that multi-walled carbon nanotubes (MWCNTs) and graphene platelets were formed on Ni/SiO₂, while only MWCNTs were deposited on all binary oxide supported Ni catalysts.     

A hybrid genetic algorithm and chaotic function model for image encryption

The security of digital images has attracted much attention recently. In this study, a new method based on a hybrid model is proposed for image encryption. The hybrid model is composed of a genetic algorithm and a chaotic function. In the first stage of the proposed method, a number of encrypted images are constructed using the original image and the chaotic function. In the next stage, these encrypted images are used as the initial population for the genetic algorithm. In each stage of the genetic algorithm, the answer obtained from the previous iteration is optimized to produce the best-encrypted image. The best-encrypted image is defined as the image with the highest entropy and the lowest correlation coefficient among adjacent pixels.     

Road Aware Geographical Routing Protocol Coupled with Distance,Direction and Traffic Density Metrics for Urban Vehicular Ad Hoc Networks

The new information and communication technologies have changed the trend of communication in all fields. The transportation sector is one of the emerging field, where vehicles are communicating with each other or with infrastructure for different safety and comfort applications in the network. Vehicular ad hoc networks is one of the emerging multi-hop communication type of intelligent transportation field to deal with high mobility and dynamic vehicular traffic to deliver data packets in the network. The high mobility and dynamic topologies make the communication links unreliable and leads to frequent disconnectivity, delay and packet dropping issues in the network. To address these issues, we proposed a road aware geographical routing protocol for urban vehicular ad hoc networks. The proposed routing protocol uses distance, direction and traffic density routing metrics to forward the data towards the destination. The simulation results explore the better performance of proposed protocol in terms of data delivery, network delay and compared it with existing geographical routing protocols.

     

术后辅助放化疗与单纯手术治疗在胃腺癌中的比较

Objective: Despite resection with curative intent, a majority of patients with gastric cancer will develop disease recurrence. Postoperative adjuvant chemo-radiotherapy increase the curability of surgery, prevent local recurrence and improve survival. Methods: Between December 2005 and February 2010, 33 patients were eligible for the study, 17 patients were randomly assigned for chemo-radiotherapy (GI) and 16 patients with surgery alone (GII). Patients in GI received chemotherapy (fluorouracil, 425 mg/m2/day, and leucovorin, 20 mg/m2/day, for 5 days) was initiated on day 1 and was followed by chemo-radiotherapy beginning 28 days after the start of the initial cycle of chemotherapy. Chemo-radiotherapy consisted of 4500 cGy of radiation at 180 cGy/day, five days/week for five weeks, with fluorouracil (400 mg/m2/day) and leucovorin (20 mg/m2/day) on the first four and the last four days of radiotherapy. One month after the completion of radiotherapy, two five-day cycles of fluorouracil (425 mg/m2/day) plus leucovorin (20 mg/m2/day) were given one month apart. Results: Grade 3 gastrointestinal toxicity was more common (23.2%) while grade 3 hematological toxicity were (5.8%). Both 3-year survival (53%) and disease free survival (41%) rates were higher in GI than in GII in which they were 43.7% and 31% respectively. Relapse rate was higher in GII (56.3%) than in GI (35.3%). Conclusion: The present study revealed that chemo-radiotherapy after gastric resection in patients with gastric adenocarcinoma improves survival and relapse rates with manageable toxicities. However, studies with larger number of patients are recommended to confirm our results.