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91.
Dietrich E. Lorke Syed M. Nurulain Mohamed Y. Hasan Kamil Ku
a Georg A. Petroianu 《International journal of molecular sciences》2021,22(6)
Poisoning with organophosphorus compounds (OPCs) represents an ongoing threat to civilians and rescue personal. We have previously shown that oximes, when administered prophylactically before exposure to the OPC paraoxon, are able to protect from its toxic effects. In the present study, we have assessed to what degree experimental (K-27; K-48; K-53; K-74; K-75) or established oximes (pralidoxime, obidoxime), when given as pretreatment at an equitoxic dosage of 25% of LD01, are able to reduce mortality induced by the OPC azinphos-methyl. Their efficacy was compared with that of pyridostigmine, the only FDA-approved substance for such prophylaxis. Efficacy was quantified in rats by Cox analysis, calculating the relative risk of death (RR), with RR=1 for the reference group given only azinphos-methyl, but no prophylaxis. All tested compounds significantly (p ≤ 0.05) reduced azinphos-methyl-induced mortality. In addition, the efficacy of all tested experimental and established oximes except K-53 was significantly superior to the FDA-approved compound pyridostigmine. Best protection was observed for the oximes K-48 (RR = 0.20), K-27 (RR = 0.23), and obidoxime (RR = 0.21), which were significantly more efficacious than pralidoxime and pyridostigmine. The second-best group of prophylactic compounds consisted of K-74 (RR = 0.26), K-75 (RR = 0.35) and pralidoxime (RR = 0.37), which were significantly more efficacious than pyridostigmine. Pretreatment with K-53 (RR = 0.37) and pyridostigmine (RR = 0.52) was the least efficacious. Our present data, together with previous results on other OPCs, indicate that the experimental oximes K-27 and K-48 are very promising pretreatment compounds. When penetration into the brain is undesirable, obidoxime is the most efficacious prophylactic agent already approved for clinical use. 相似文献
92.
The effects of natural disasters, pandemic-induced lockdowns, and other disruptions often cascade across networks. In this work, we use minimum cost of resilience (MCOR) and operation-based resilience metrics to quantify network performance against single-connectivity failures and identify critical connections in interconnected networks. MCOR corresponds to the minimum additional infrastructure investment that is required to achieve a certain level of resilience. To guarantee MCOR, we incorporate the metrics in a multi-scenario mixed-integer linear program (MILP) that accounts for resilience in the design phase of interconnected networks. The goal is to obtain optimal generation and transportation capacities with flexible operation under all single-connectivity disruption scenarios. We demonstrate the applicability of our resilience-aware framework on a water-energy nexus (WEN) example focusing on grass-root design and retrofitting. We further apply the framework to analyze a regional WEN and observe that it is possible to achieve “full” resilience in the expense of additional regional investments. 相似文献
93.
Mohammad Mizanur Rahman Md. Hasan Zahir Md. Eyasin Arafat Mohammad Abu Jafar Mazumder Rami Suleiman A. Madhan Kumar 《应用聚合物科学杂志》2021,138(9):49904
A waste material called oil fly ash (OFA) was acid-functionalized, yielding f-OFA-COOH, which was then reacted with cerium oxide (CeO2) to make CeO2-functionalized OFA, or f-OFA-CeO2. Pristine OFA and f-OFA-CeO2 were used to make waterborne polyurethane (WBPU) dispersions, referred to as WBPU/OFA and WBPU/f-OFA-CeO2, respectively, with defined OFA and f-OFA-CeO2 content. All the dispersions were applied to mild steel as organic coatings to evaluate their protective properties, such as their hydrophobicity, adhesive strength and UV-shielding resistance. These protective properties varied based on the OFA and f-OFA-CeO2 content. The highest water contact angle, minimum water swelling and maximum adhesive strength were found using WBPU/f-OFA-CeO2-20 coating (using 2.00 wt% f-OFA-CeO2), which also showed the maximum ultraviolet (UV) absorption via UV–vis spectroscopy analysis. This UV shielding result also matched field test results, as that coating was found to exhibit the lowest UV degradation near a marine atmosphere, as shown by X-ray photoelectron spectroscopy (XPS) analysis. The least affected hydrophobicity was also recorded for the sample with the WBPU/f-OFA-CeO2-20 coating. 相似文献
94.
Md. Najmol Hoque Md. Tahjib-Ul-Arif Afsana Hannan Naima Sultana Shirin Akhter Md. Hasanuzzaman Fahmida Akter Md. Sazzad Hossain Md. Abu Sayed Md. Toufiq Hasan Milan Skalicky Xiangnan Li Marin Bresti
《International journal of molecular sciences》2021,22(21)
Heavy metal toxicity is one of the most devastating abiotic stresses. Heavy metals cause serious damage to plant growth and productivity, which is a major problem for sustainable agriculture. It adversely affects plant molecular physiology and biochemistry by generating osmotic stress, ionic imbalance, oxidative stress, membrane disorganization, cellular toxicity, and metabolic homeostasis. To improve and stimulate plant tolerance to heavy metal stress, the application of biostimulants can be an effective approach without threatening the ecosystem. Melatonin (N-acetyl-5-methoxytryptamine), a biostimulator, plant growth regulator, and antioxidant, promotes plant tolerance to heavy metal stress by improving redox and nutrient homeostasis, osmotic balance, and primary and secondary metabolism. It is important to perceive the complete and detailed regulatory mechanisms of exogenous and endogenous melatonin-mediated heavy metal-toxicity mitigation in plants to identify potential research gaps that should be addressed in the future. This review provides a novel insight to understand the multifunctional role of melatonin in reducing heavy metal stress and the underlying molecular mechanisms. 相似文献
95.
Teoman Dogru Ali Kirik Hasan Gurel Ali A. Rizvi Manfredi Rizzo Alper Sonmez 《International journal of molecular sciences》2021,22(12)
Nonalcoholic fatty liver disease (NAFLD) is strongly associated to the features of metabolic syndrome which can progress to cirrhosis, liver failure and hepatocellular carcinoma. However, the most common cause of mortality in people with NAFLD is not liver-related but stems from atherosclerotic cardiovascular disease (CVD). The prevalence of NAFLD is on the rise, mainly as a consequence of its close association with two major worldwide epidemics, obesity and type 2 diabetes (T2D). The exact pathogenesis of NAFLD and especially the mechanisms leading to disease progression and CVD have not been completely elucidated. Human fetuin-A (alpha-2-Heremans Schmid glycoprotein), a glycoprotein produced by the liver and abundantly secreted into the circulation appears to play a role in insulin resistance, metabolic syndrome and inflammation. This review discusses the links between NAFLD and CVD by specifically focusing on fetuin-A’s function in the pathogenesis of NAFLD and atherosclerotic CVD. 相似文献
96.
SPARCL: an effective and efficient algorithm for mining arbitrary shape-based clusters 总被引:3,自引:3,他引:0
Vineet Chaoji Mohammad Al Hasan Saeed Salem Mohammed J. Zaki 《Knowledge and Information Systems》2009,21(2):201-229
Clustering is one of the fundamental data mining tasks. Many different clustering paradigms have been developed over the years,
which include partitional, hierarchical, mixture model based, density-based, spectral, subspace, and so on. The focus of this
paper is on full-dimensional, arbitrary shaped clusters. Existing methods for this problem suffer either in terms of the memory
or time complexity (quadratic or even cubic). This shortcoming has restricted these algorithms to datasets of moderate sizes.
In this paper we propose SPARCL, a simple and scalable algorithm for finding clusters with arbitrary shapes and sizes, and
it has linear space and time complexity. SPARCL consists of two stages—the first stage runs a carefully initialized version
of the Kmeans algorithm to generate many small seed clusters. The second stage iteratively merges the generated clusters to
obtain the final shape-based clusters. Experiments were conducted on a variety of datasets to highlight the effectiveness,
efficiency, and scalability of our approach. On the large datasets SPARCL is an order of magnitude faster than the best existing
approaches. 相似文献
97.
Ahmad Feyz Dizaji Hossein Ali Sepiani Farzad Ebrahimi Akbar Allahverdizadeh Hasan Ali Sepiani 《Journal of Mechanical Science and Technology》2009,23(8):2299-2307
An initial-boundary value problem that is Duffing’s oscillator with time varying coefficients will be studied. Using Banach’s
fixed-point theorem, the existence of periodic solution of the equation will be predicted. The method applied in this paper
is the Schauder second fixed point theorem, which includes the response of structures under vibratory force systems. As an
example, the dynamics of nonlinear simply supported rectangular thin plate under influence of a relatively moving mass is
studied. By expansion of the solution as a series of mode functions, the governing equations of motion are reduced to an ordinary
differential equation for time development vibration amplitude, which is Duffing’s oscillator. Finally, a parametric study
is developed, after that some numerical examples are solved, and the validity of the present analysis is clearly shown.
This paper was recommended for publication in revised form by Associate Editor Maenghyo Cho
Hossein Ali Sepiani received his B.S. degree in Mechanical Engineering from University of Kashan, Iran, in 2003. He then received his M.S. degree
from University of Tehran, in 2006. Currently, Hossein is continuing his research at University of Tehran. His research interests
include new materials (FGMs, Nano-materials, SMAs, SMPs, etc), Composites (Woven Fabrics and Fiber Metal Laminates), Smart
Materials (Shape Memory Alloy, Magnet/Electro-rheological and Piezoelectric Sensors and Actuators), Intelligent structures
(Structures integrated with smart materials), Vibration and control of Intelligent Structures and their application.
Ahmad Feyz Dizaji got his B.S. degree from University of Tehran, Iran, in 1970. Then he continued his study in U.S. and received his PhD. degree
from Michigan State University in 1983, in Applied Mathematics under the supervision of Professor Shui-ni Chow and Professor
J. Mallet-Paret. Since then he has been a member of the Faculty of Engineering in University of Tehran, teaching mathematics
in both undergraduate and graduate levels. 相似文献
98.
The purpose of this study was to evaluate the knowledge, attitudes and practices among food service staff with regards to food hygiene in hospitals in Edirne, Turkey, and to provide baseline data for implementing HACCP in hospital food services by carrying out a questionnaire by a face-to-face interview. The current study shows that food service staff in Edirne hospitals have insufficient knowledge regarding the basics of food hygiene. And also revealed a discrepancy between attitudes and practices towards food hygiene. There is an immediate need for continuous training among food handlers regarding safe food handling practices. 相似文献
99.
Authors Index
JNSM Volume 10 (2002) Reviewers 相似文献100.
The objective of testing is to determine whether an implementation under test conforms to its specification. In distributed
test architectures involving multiple remote testers, this objective can be complicated by the fact that testers may encounter
coordination problems relating to controllability (synchronization) and observability during the application of tests. Based
on a finite state machine (FSM) specification of the externally observable behaviour of a distributed system and a distinguishing
sequence, this paper proposes a method for constructing a checking sequence where there is no potential controllability or
observability problems, and where the use of external coordination message exchanges among testers is minimized. The proposed
method does not assume a reliable reset feature in the implementations of the given FSM to be tested by the resulting checking
sequence.
phone: 613-562-5800(Extn)6684
Received May 2004
Revised March 2005
Accepted April 2005 by J. Derrick, M. Harman and R. M. Herons 相似文献