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81.
MA Fischl DD Richman C Flexner MF Para R Haubrich A Karim P Yeramian J Holden-Wiltse PM Meehan 《Canadian Metallurgical Quarterly》1997,15(1):28-34
A significant restriction was demonstrated in the ability of herpes simplex virus type 1 virion host shutoff (vhs) mutant viruses to invade the corneal epithelium. Viral replication and invasion was confined to the areas of the cornea which were scarified prior to infection. Differences between wild-type and vhs mutant replication in corneas in vivo were 100- to 1000-fold at all timepoints postinfection. Smaller but still significant growth restrictions were observed in cultured corneal cells. This difference between in vitro and in vivo is not likely to be due to differences in cell cycle status since vhs-induced RNA degradation can occur in both cycling and noncycling cells in vitro. The vhs function is therefore important for invasion of the cornea and secondarily the nervous system and is thereby required for efficient establishment of latency. 相似文献
82.
Heats of solution at infinite dilution of solutes in poly(ethyl methacrylate) were estimated using gas–liquid chromatography over a temperature range of 417.74 K–427.55 K. The heat of solution is related to solute polarizability and dipole moment. Contributions of specific interactions such as hydrogen bonding and charge-transfer complexing to the enthalpy of solution were also determined. 相似文献
83.
It is shown experimentally that flattened tubes give higher laminar-flow heat transfer coefficients than tubes of circular cross-section. Part of the increase is due to an increase in the tube-wall shear rate; the magnitude of this effect is predicted and checked by reference to the behaviour of Newtonian liquids. The other part is due to secondary flow patterns which develop in viscoelastic liquids; this effect is at a maximum when the aspect ratio of the tube cross-section is of the order 1.5:1. The first effect may increase heat transfer coefficient by over 90% and the latter by over 45%. 相似文献
84.
Comparison of spectral fluorescent signatures-based models to characterize DOM in treated water samples 总被引:1,自引:0,他引:1
Statistical procedures enable a multivariate analysis of the measurements to identify specific characteristics of the dissolved organic matter (DOM) fractions in raw natural water, including the concentrations. In this work, three already established models were used to predict the concentrations of fractions of DOM from spectral fluorescent signatures (SFSs): a general linear regression (GLR), loadings and scores of a principal components analysis (PCA), and a partial least squares regression (PLS). Details about the method undertaken to prepare the fractions were given. Water samples from surface water treatment plants in New Jersey were used for the testing. In all cases, PLS have shown much better biases and accuracies than GLR and PCA models. Hydrophilic neutral, however, showed poor performances (bias 33%) due to the isolation technique used. Recommendations were provided in order to improve the DOM characterization through SFS, which linked to PLS make a powerful and cost-effective surrogate parameter to characterize DOM. 相似文献
85.
Semdé R Moës AJ Devleeschouwer MJ Amighi K 《Drug development and industrial pharmacy》2003,29(2):203-213
The water solubility of pectin was successfully decreased by cross-linking with increasing amounts of epichlorohydrin in the reaction media. The initial molar ratios of epichlorohydrin/ galacturonic acid monomer in the reaction mixtures were 0, 0.37, 0.56, 0.74, 1.00, 1.47, and 2.44. The resulting epichlorohydrin cross-linked pectins were thus referred to as C-LP0, C-LP37, C-LP56, C-LP75, C-LP100, C-LP150, and C-LP250, respectively. Methoxylation degrees ranged from 60.5 ± 0.9% to 68.0 ± 0.6%, and the effective cross-linking degrees, determined by quantification of the hydroxyl anions consumed during the reaction, were 0, 17.8, 26.0, 38.3, 46.5, 53.5, and 58.7%, respectively. After incubating the different cross-linked pectins (0.5% w/v) in 25 mL of 0.05 M acetate-phosphate buffer (pH 4.5), containing 50 µL of Pectinex® Ultra SP-L (pectinolytic enzymes), between 60 and 80% of the pectin osidic bounds were broken in less than 1 hr. Moreover, increasing the cross-linking degree only resulted in a weak slowing on the enzymatic degradation velocity. 相似文献
86.
Karim S. Karam Jad S. Karam Herbert H. Einstein 《Canadian Metallurgical Quarterly》2007,133(5):354-363
Tunnel exploration is a classic problem of decision making under uncertainty. This paper, Part II, dealing with the exploration problem, discusses the sources of uncertainty in tunnel exploration, and provides techniques to formally incorporate uncertainties into the exploration planning. Part I described the state of uncertainty in geology and exploration reliability using assigned probabilities. These probabilities are, however, uncertain. Construction costs are also uncertain. This paper presents tools with which the decision maker is able to assess the effects of these uncertainties on exploration decisions. Decisions are therefore made based on the value of collecting new, uncertain information through “virtual” exploration prior to actually exploring. 相似文献
87.
Adil Karim Jason Devenport 《Photonics Technology Letters, IEEE》2007,19(5):312-314
An octave-bandwidth microwave photonic link with a third-order limited spurious-free dynamic range of 121 dB in a 1-Hz bandwidth has been demonstrated. The link noise figure of 9 dB at a modulation frequency of 2 GHz was achieved by using a bias-shifted Mach-Zehnder modulator with an optical input power of 500 mW. This level of performance was realized without electronic or optical linearization 相似文献
88.
This paper investigates the changes that are required in networking technology for ‘everything over IP’ to become a reality.
Initially the changes that are taking place in the telecommunications industry are reviewed. This review ranges from a discussion
about the companies installing massive global IP networks to the emergence of novel routeing technologies, e.g. multi-protocol
label switching (MPLS) and terabit router technologies. The role of existing telecommunications operators is then discussed,
along with the reasons why they are developing interworking and intelligence layers based on distributed computing principles
to support all their networks — mobile, fixed, broadband and IP. 相似文献
89.
Karim Salahshoor Ehsan Safari Iraj Ahangari 《Engineering Applications of Artificial Intelligence》2013,26(5-6):1512-1531
This paper proposes a new adaptive nonlinear model predictive control (NMPC) methodology for a class of hybrid systems with mixed inputs. For this purpose, an online fuzzy identification approach is presented to recursively estimate an evolving Takagi–Sugeno (eTS) model for the hybrid systems based on a potential clustering scheme. A receding horizon adaptive NMPC is then devised on the basis of the online identified eTS fuzzy model. The nonlinear MPC optimization problem is solved by a genetic algorithm (GA). Diverse sets of test scenarios have been conducted to comparatively demonstrate the robust performance of the proposed adaptive NMPC methodology on the challenging start-up operation of a hybrid continuous stirred tank reactor (CSTR) benchmark problem. 相似文献
90.
Karim Salahshoor Sepide Zakeri Morteza Haghighat Sefat 《Engineering Applications of Artificial Intelligence》2013,26(8):1902-1910
Producing oil from gas-lift wells are often faced with severe producing oscillatory flow regimes. A major source of the oscillations is recognized as casing–heading instability which is caused by dynamic interaction between injection gas and multiphase fluid. This phenomenon poses strict production-related challenges in terms of lower average production and strain on downstream equipment. In this paper, an effective solution is proposed based on integration of an online interpretation dynamic model and a nonlinear model predictive control (NMPC) scheme. The paper uses adaptive growing and pruning radial basis function (GAP-RBF) neural networks (NNs) to recursively capture the essential dynamics of casing–heading instability in a nonlinear model structure. Extended Kalman filter (EKF) and unscented Kalman filter (UKF) are comparatively investigated to adaptively train modified GAP-RBF NNs. NMPC methodology is developed on the basis of the identified nonlinear NN model for real-time stabilization of casing–heading instability in an oil reservoir equipped with a gas-lift production well. A set of test studies has been conducted to explore the superior performance of the proposed adaptive NMPC controller under different scenarios for an oil reservoir simulated in ECLIPSE and linked to a complementary gas-lifted oil well simulated in programming environment. 相似文献