Efficacy and tolerability of brodimoprim od versus norfloxacin bid in the treatment of bacterial urinary tract infections

The efficacy and tolerability of brodimoprim OD versus norfloxacin BID were studied in patients affected by bacterial urinary tract infections. The study was performed in 203 patients divided into two parallel randomized groups orally given either brodimoprim 400 mg OD on the first day followed by 200 mg OD for 2 days, or norfloxacin 400 mg BID respectively. The efficacy of treatment was evaluated by the bacterial cultures, tolerability, analysis of signs and symptoms, a complete physical examination and from laboratory data. The results showed that brodimoprim and norfloxacin in the majority of patients resulted in a reduction of fever and symptoms caused by the infective process. Of the 103 patients enrolled in the brodimoprim OD group, 99 had a complete course of therapy with a positive outcome. There was only one case of failed treatment and 3 cases which could not be evaluated because of voluntary interruption of treatment. Of the 100 patients treated with norfloxacin BID, 94 completed therapy with a positive clinical outcome and there were 4 cases of treatment failure. Thus the efficacy of brodimoprim OD appears comparable to that of norfloxacin BID in the treatment of urinary tract infections.     

Atrial mapping and radiofrequency catheter ablation in patients with idiopathic atrial fibrillation. Electrophysiological findings and ablation results

BACKGROUND: Knowledge of the electrophysiological substrates and the cure of atrial fibrillation (AF) is still unsatisfactory. The goal of this study was to evaluate the electrophysiological features of idiopathic AF and their relationship to the results of radiofrequency (RF) catheter ablation of AF and the safety and effectiveness of this procedure. METHODS AND RESULTS: Sixteen patients with idiopathic AF underwent atrial mapping during AF and then RF ablation in the right atrium. The atrial activation was simultaneously recorded in four regions in the right atrium: high lateral wall (HL), low lateral wall (LL), high septum (HS), and low septum (LS) and in the left atrium through the coronary sinus (CS). In these regions, we evaluated the atrial fibrillation intervals (FF) and the morphological features of AF recordings by Wells' classification. No complications occurred during RF ablation. Of the 16 patients, 9 (56%) without AF recurrences during the follow-up (11 +/- 4 months) were considered successfully ablated. These patients showed a significantly shorter mean FF interval in the HS and the LS (122 +/- 32 and 126 +/- 28 ms, respectively), than in the HL and LL (159 +/- 24 and 156 +/- 28 ms, respectively). Moreover, the septum had more irregular electrical activity with greater beat-to-beat changes in FF and a higher prevalence of type III AF than the lateral region. The CS had similar behavior to the septum. Conversely, patients with unsuccessful ablation had an irregular atrial activity in the lateral wall, septum, and CS with no significant differences between the different sites. CONCLUSIONS: Right atrial endocardial catheter ablation of AF is a safe procedure and may be effective in some patients with idiopathic AF. The atrial mapping during AF showed a more disorganized right atrial activation in the septum than in the lateral wall in patients with successful ablation.     

Looking happy: The experimental manipulation of a positive visual attention bias.

Individuals with a positive visual attention bias may use their gaze to regulate their emotions while under stress. The current study experimentally trained differential biases in participants' (N = 55) attention toward positive or neutral information. In each training trial, one positive and one neutral word were presented and then a visual target appeared consistently in the location of the positive or neutral words. Participants were instructed to make a simple perceptual discrimination response to the target. Immediately before and after attentional training, participants were exposed to a stress task consisting of viewing a series of extremely negative images while having their eyes tracked. Visual fixation time to negative images, assessed with an eye tracker, served as an indicator of using gaze to successfully regulate emotion. Those participants experimentally trained to selectively attend to affectively positive information looked significantly less at the negative images in the visual stress task following the attentional training, thus demonstrating a learned aversion to negative stimuli. Participants trained toward neutral information did not show this biased gaze pattern. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Hypnotic dissociation, dichotic listening, and active versus passive modes of attention.

Describes 2 experiments with 75 high and low hypnotically susceptible Ss (Harvard Group Scale of Hypnotic Susceptibility). Detecting left-channel targets interfered less with the shadowing of right-channel prose when performance of the former task was posthypnotically dissociated from consciousness. However, this superiority over an ordinary divided-attention condition was not due to unconscious target detection by Ss. Rather, the suggestions for posthypnotic responsiveness with amnesia apparently engendered a passive mode of attention to the left-channel task, such that Ss did not actively listen for targets in order to hear them. In Exp II, explicit instructions to adopt a strategy of attentional passivity to the target-detection task proved to be far more effective in producing the reduced-interference effect than the posthypnotic suggestions had been. The posthypnotic suggestions seemed to induce attentional passivity as an indirect effect of amnesia for the posthypnotic suggestions and for previously detected targets. Study findings are interpreted in terms of E. R. Hilgard's (1973) neodissociation theory. (24 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

New cubane MOCVD precursors for gallium sulphide and gallium selenide: Synthesis of [(Et2MeC)GaS]4 and [(Me2EtC)GaS]4: Structural determinations of [(Et2MeC)GaS]4 by X-ray diffraction and [(tBu)GaSe]4 by electron diffraction

The gallium sulphide cubane compounds [(Me₂EtC)GaS]₄ and [(Et₂MeC)GaS]₄, have been synthesised, and their potential as MOCVD precursors for GaS is discussed. The molecular structure of [(Et₂MeC)GaS]₄ has been determined by X-ray diffraction. In addition, the vapour phase structure of the GaSe precursor, [(^tBu)GaSe]₄ has been determined by gas phase electron diffraction and is compared with that previously determined in the solid state by X-ray diffraction.     

Reduction of proteolysis during ensilage of perennial ryegrass by protease inhibitors

Two experiments were carried out to assess the effectiveness of protease inhibitors in reducing proteolysis during ensilage. Perennial ryegrass (Lolium perenne) (279 g dry matter (DM) kg^?1, experiment 1 and 170 gDM kg^?1 experiment 2) was ensiled in laboratory silos for 82 and 50 days, respectively. With the exception of the application of formic acid (1.5 g kg^?1) plus formalin (3 g kg^?1) in experiment 1, all silages had pH values of less than 4.0 and lactic acid concentrations of greater than 100 g kg^?1 DM. Application of the cysteine endopeptidase inhibitor E-64 (1-trans-epoxysuccinyl-leucylamido(4-guanidino) butane, 22.5 mg kg^?1 reduced proteolysis during ensilage as measured by a reduction in the quantities of soluble non-protein N in silage to 0.76 and 0.91 of control values (528 and 643 g kg^?1 total N) in experiments 1 and 2, respectively. In experiment 2 increasing the application rate of E-64 from 22.5 to 45 mg kg^?1 further reduced the extent of proteolysis from 0.91 to 0.75 of control soluble non-protein N concentrations. Proteolysis was also reduced in experiment 2 by two other cysteine endopeptidase inhibitors, antipain (32 mg kg^?1, 0.81 of control) and cystain (1.2 mg kg^?1; 0.89 of control). Pepstatin A (300 mg kg^?1), an inhibitor of aspartic acid endopeptidases, did not reduce soluble non-protein N concentrations in experiment 1 but did do so in experiment 2 (0.81 of control). Treatment of grass at ensiling with Lactobacillus plantarum (10⁶ g^?1) reduced silage non-protein N concentrations to 0.83 of the control. The effects of E-64 and pepstatin A and of E-64 and L plantarum in experiment 2 were addive. Cysteine endopeptidases therefore play an important role in protein breakdown during ensilage.