Refrigeration and thermometry of liquid3He-4He mixtures in the ballistic regime

The ballistic regime of liquid³He-⁴He mixtures is characterized by a large mean free path of the thermal excitations compared to the characteristic dimension of the experiment. We report on investigations of the transport properties of mixtures as well as superfluid³He in the ballistic regime by means of the vibrating wire technique. In order to avoid possible sources of heat leaks into the liquid, the experimental setup was built as far as possible of pure materials only. The contribution of a Ag sinter to the heat leak as well as its influence on the attainable minimum temperature of the mixtures were investigated by performing measurements in two similar setups which differed in the size of the heat exchanger by about one order of magnitude. Moreover, we have used the vibrating wire partly immersed in the superfluid³He-B phase of a phase-separated mixture as a very sensitive, continuously monitoring thermometer for liquid mixtures in their ballistic regime. The achieved minimum temperature of a 6.8%-mixture atp = 0.35 bar and of a 9.5%-mixture atp = 9.8 bar was 130 K. This value can be considered as an upper limit for the temperature of the mixtures as the damping of the vibrating wire thermometer saturates at this temperature due to its intrinsic properties.     

Working models of attachment and reactions to different forms of caregiving from romantic partners.

Inspired by attachment theory, the authors tested a series of theoretically derived predictions about connections between attachment working models (attachment to one's parents assessed by the Adult Attachment Interview; M. Main & R. Goldwyn, 1994) and the effectiveness of specific types of caregiving spontaneously displayed by dating partners during a stressful conflict-resolution discussion. Each partner first completed the Adult Attachment Interview. One week later, each couple was videotaped while they tried to resolve a current problem in their relationship. Trained observers then rated each interaction for the degree to which (a) emotional, instrumental, and physical caregiving behaviors were displayed; (b) care recipients appeared calmed by their partners' caregiving attempts; and (c) each partner appeared distressed during the discussion. Individuals who had more secure representations of their parents were rated as being more calmed if/when their partners provided greater emotional care, especially if they were rated as more distressed. Conversely, individuals who had more insecure (dismissive) representations of their parents reacted more favorably to instrumental caregiving behaviors from their partners, especially if they were more distressed. The broader theoretical implications of these findings are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Low-level temporal coding impairments in psychosis: Preliminary findings and recommendations for further studies.

The authors investigated whether difficulties with temporal event coding, previously reported in patients with schizophrenia, are already present during first-episode psychosis (FEP). In this experiment, the subjective judgments of the simultaneity of visually presented stimuli were compared between 11 healthy controls, 9 patients with chronic schizophrenia (CSZ), and a sample of 11 FEP patients. Participants were asked to indicate whether 2 vertical bars appeared at the same time or at different times on a computer monitor. CSZ patients' thresholds were elevated, and the FEP sample showed higher thresholds relative to controls. Although preliminary, these findings indicate a generalized disturbance in event-structure coding at early stages of psychosis and question the specificity of its disturbance. Considering the proposed relationship between event-structure coding and the experience of time in general, this study recommends that future studies refocus on psychosis in general, rather than on schizophrenia as a particular case of abnormal temporal processing. In addition, it is suggested that the relevant psychopathology will be best determined by means of a comprehensive analysis of low-level temporal coding performance in different types of psychosis. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Using UV Photography to Reduce Use of Tanning Booths: A Test of Cognitive Mediation.

Two laboratory studies were conducted in which a new type of intervention was used to reduce ultraviolet radiation (UV) exposure from tanning booth use among college students (Time 1 Ns=70 and 134). The intervention uses UV photography to highlight the damage to facial skin caused by previous UV exposure. When the authors controlled for baseline measures of booth use, students in both studies who viewed their UV photographs reported less booth use at a follow-up session 3-4 weeks later than did students not shown a copy of their photograph. Also, in both studies, the decline in use was significantly mediated by a Tanning Cognition Index composed of variables suggested by the prototype-willingness (prototype) model of health risk: tanning attitudes, tanner prototypes, and willingness to engage in risky UV exposure. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Age Differences in Everyday Problem-Solving and Decision-Making Effectiveness: A Meta-Analytic Review.

The authors report a meta-analysis of age differences in everyday problem-solving/decision-making effectiveness (EPSE). Effect sizes were calculated to reflect 3 age group comparisons: old versus young, young versus middle-aged, and middle-aged versus old. Findings from the meta-analysis of 28 separate studies with an aggregate of 4,482 participants do not support theories of preserved EPSE in late adulthood. Although significant age differences of moderate magnitude persisted across methodological and theoretical domains, rating criteria (experimenter vs. participant) emerged as a significant moderator of the effect magnitude and direction. In addition, EPSE in older adults was bolstered when problem content was interpersonal and when samples were highly educated. Finally, the current results support the conceptual integration of findings from the everyday problem-solving and everyday decision-making literatures. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Accountability in Child Welfare Services: Developing a Statewide Outcome Evaluation Program.

Questions are often raised regarding the effectiveness and value of treatment programs for children and families. Recently, programs have been increasingly held accountable for services offered. In response, the member agencies of IARCCA have developed a comprehensive outcome measurement program. This article describes the project, focusing on the conditions that led to its inception and how the measurement plan was developed. In addition, the article includes information on the selection of personnel, measurement instruments, and methods and on the process of data collection. Summary results are provided, including how these results are utilized to improve services. Finally, the continued expansion and future directions of the Outcome Project are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate

Vascular endothelial growth factor (VEGF) is a potent and selective vascular endothelial cell mitogen and angiogenic factor. VEGF expression is elevated in a wide variety of solid tumors and is thought to support their growth by enhancing tumor neovascularization. To block VEGF-dependent angiogenesis, tumor cells were transfected with cDNA encoding the native soluble FLT-1 (sFLT-1) truncated VEGF receptor which can function both by sequestering VEGF and, in a dominant negative fashion, by forming inactive heterodimers with membrane-spanning VEGF receptors. Transient transfection of HT-1080 human fibrosarcoma cells with a gene encoding sFLT-1 significantly inhibited their implantation and growth in the lungs of nude mice following i.v. injection and their growth as nodules from cells injected s.c. High sFLT-1 expressing stably transfected HT-1080 clones grew even slower as s.c. tumors. Finally, survival was significantly prolonged in mice injected intracranially with human glioblastoma cells stably transfected with the sflt-1 gene. The ability of sFLT-1 protein to inhibit tumor growth is presumably attributable to its paracrine inhibition of tumor angiogenesis in vivo, since it did not affect tumor cell mitogenesis in vitro. These results not only support VEGF receptors as antiangiogenic targets but also demonstrate that sflt-1 gene therapy might be a feasible approach for inhibiting tumor angiogenesis and growth.     

Particulate Matter Intervention Study: A Causal Factor of Building-Related Symptoms in an Older Building

Abstract Five floors of a 20-year old 6-story office building were investigated using an integrated step-by-step investigation strategy. This involved a walkthrough inspection, an occupant questionnaire, and targeted environmental monitoring of indoor air quality and comfort parameters. The initial questionnaire survey revealed a high occurrence of building-related symptoms. The walkthrough inspection and environmental monitoring identified deposits of surface dust (indoor surface pollution – ISP) on carpets and hard surfaces, and elevated levels of carbon dioxide and respirable suspended particulate matter (RSP) throughout the building. An intervention study (blinded to the occupants) was targeted at reducing ISP levels by replacing normal carpet cleaning practices with higher performance vacuum cleaners and improved cleaning practices. The intervention reduced ISP levels and significantly lowered RSP concentrations by approx. 80% from initial values and against control floors. A follow-up SBS questionnaire revealed significant reductions in all but two of the symptoms. The most significant reductions occurred with symptoms of eye irritation, throat irritation, dry unproductive cough, and nose irritation. The study showed that in older buildings with poor ventilation, a build-up of ISP, and elevated RSP levels, using higher performance carpet cleaning practices can reduce RSP to acceptable levels and can reduce SBS symptoms.