Ropes: An alternative to strings

Programming languages generally provide a ‘string’ or ‘text’ type to allow manipulation of sequences of characters. This type is usually of crucial importance, since it is normally mentioned in most interfaces between system components. We claim that the traditional implementations of strings, and often the supported functionality, are not well suited to such general-purpose use. They should be confined to applications with specific, and unusual, performance requirements. We present ‘ropes’ or ‘heavyweight’ strings as an alternative that, in our experience leads to systems that are more robust, both in functionality and in performance. Ropes have been in use in the Cedar environment almost since its inception, but this appears to be neither well-known, nor discussed in the literature. The algorithms have been gradually refined. We have also recently built a second similar, but somewhat lighter weight, C-language implementation, which is included in our publically released garbage collector distribution. We describe the algorithms used in both, and give some performance measurements for the C version.     

Inheritance and genetic mapping of resistance to Alternaria alternata f. sp. lycopersici in Lycopersicon pennellii

The fungal pathogen Alternaria alternata f. sp. lycopersici produces AAL-toxins that function as chemical determinants of the Alternaria stem canker disease in the tomato (Lycopersicon esculentum). In resistant cultivars, the disease is controlled by the Asc locus on chromosome 3. Our aim was to characterize novel sources of resistance to the fungus and of insensitivity to the host-selective AAL-toxins. To that end, the degree of sensitivity of wild tomato species to AAL-toxins was analyzed. Of all members of the genus Lycopersicon, only L. cheesmanii was revealed to be sensitive to AAL-toxins and susceptible to fungal infection. Besides moderately insensitive responses from some species, L. pennellii and L. peruvianum were shown to be highly insensitive to AAL-toxins as well as resistant to the pathogen. Genetic analyses showed that high insensitivity to AAL-toxins from L. pennellii is inherited in tomato as a single complete dominant locus. This is in contrast to the incomplete dominance of insensitivity to AAL-toxins of L. esculentum. Subsequent classical genetics, RFLP mapping and allelic testing indicated that high insensitivity to AAL-toxins from L. pennellii is conferred by a new allele of the Asc locus.     

Panel 1: PVC Resins—past,present and future

PVC Resin behavior vs VCM control; processing differences pre- and early control vs current VCM standards. Differences in fusion, bulk density, output rates—lot to lot variations; differences in plasticizer absorption and response; nature of resin particles surface; drift in K value; static charge; viscosity differences in dispersion resins; S-PVC vs M-PVC; quality control, ASTM D 1755 resin classification.     

A Cube Model for Competency Development: Implications for Psychology Educators and Regulators.

This article provides a conceptual framework for training in professional psychology focused on the construct of competency. The authors present a 3-dimensional competency model delineating the domains of knowledge, skills, attitudes, and values that serve as the foundation required of all psychologists, the domains of functional competencies that broadly define what psychologists do, and the stages of professional development from doctoral education to lifelong learning through continuing education. The goal in presenting this model is to provide a conceptual frame of reference for those responsible for psychology education, credentialing, and regulation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effect of task complexity on reaction times in memory scanning and visual discrimination in Parkinson's disease

Within the context of the bradyphrenia debate, two experiments designed to measure the cognitive speed of Parkinson patients (PD) were conducted with 58 subjects. The experiments took the form of a high-speed memory scanning task using memory sets consisting of one-six words or one-six abstract figures. In a visual discrimination task, two simultaneously presented abstract images had to be compared, the complexity of the images being varied through four stages. Motor response was constant, reaction time was the dependent variable. PD differed from matched controls in the level (significant only in scanning) but in neither experiment in the slope of reaction time curves. Interaction group x complexity (MANOVA) was not significant. Correlations between disease parameters and a 'complexity effect' measure were low throughout. However, the link to general intelligence was significant. The findings contradict the conventional bradyphrenia hypothesis.     

Clients, Servers and Broadband — Making a Big Difference

'Broadband is more bandwidth than you can use.' Mark Bagley, Venation, 1999 [1].In a world where the unspoken assumption is that providing more bandwidth will solve Internet access problems, these are provocative words. The historical evidence [2] shows that adding bandwidth merely increases demand — analogous in many ways to the building of more motorways having the effect of increasing traffic problems instead of alleviating them. The result is that the world's appetite for bandwidth continues to outstrip the supply, and the only apparent solution is a spiral of ever-greater demands for bandwidth.To find an equitable solution to this conundrum, the problem itself has been re-assessed to see if there might be an alternative. It is now believed that a combination of technologies can offer a scalable solution to providing the services that people evidently want, but without requiring unfeasibly large bandwidths for network access. This paper describes a solution which uses a mixture of client/server, client-side, and peer-to-peer approaches to provide a novel answer. With mobile computing putting new constraints on the likely connection bandwidth, a technique that allows us to exploit bandwidth effectively could be a powerful weapon for the future. It also allows broadband to reveal its true potential.     

Bradykinin inhibits M current via phospholipase C and Ca2+ release from IP3-sensitive Ca2+ stores in rat sympathetic neurons

A variety of intracellular signaling pathways can modulate the properties of voltage-gated ion channels. Some of them are well characterized. However, the diffusible second messenger mediating suppression of M current via G protein-coupled receptors has not been identified. In superior cervical ganglion neurons, we find that the signaling pathways underlying M current inhibition by B2 bradykinin and M1 muscarinic receptors respond very differently to inhibitors. The bradykinin pathway was suppressed by the phospholipase C inhibitor U-73122, by blocking the IP3 receptor with pentosan polysulfate or heparin, and by buffering intracellular calcium, and it was occluded by allowing IP3 to diffuse into the cytoplasm via a patch pipette. By contrast, the muscarinic pathway was not disrupted by any of these treatments. The addition of bradykinin was accompanied by a [Ca2+]i rise with a similar onset and time to peak as the inhibition of M current. The M current inhibition and the rise of [Ca2+]i were blocked by depletion of Ca2+ internal stores by thapsigargin. We conclude that bradykinin receptors inhibit M current of sympathetic neurons by activating phospholipase C and releasing Ca2+ from IP3-sensitive Ca2+ stores, whereas muscarinic receptors do not use the phospholipase C pathway to inhibit M current channels.