Frequency-Tunable Terahertz-Wave Generation from GaP Using Cr:Forsterite Lasers

We have constructed THz spectrometers using the widely frequency-tunable THz-wave generated from GaP crystal pumped at 1.2 µm region using two Cr:forsterite lasers and compared with that pumped at 1 µm region using a YAG laser and an optical parametric oscillator (OPO). The systems have sufficient resolution for observation of solids and liquids at room temperature. We have measured Terahertz absorption spectra of all 20 kinds of amino acids which form proteins.     

High-resolution GaP Terahertz Spectrometer and Its Application to Detect Defects in Gamma-irradiated Glucose Crystal

We developed high-resolution GaP THz signal generator using Cr:Forsterite lasers with gratings as both a pump and a signal beam for difference-frequency generation. A line width of less than 500 MHz and a wide tunable frequency range (0.6–6.2 THz) provide sufficient resolution for measuring materials with sharp absorption bands using the generator as the light source for a THz spectrometer. This is suitable for materials such as gases or solid samples at low temperatures. We demonstrated the detection of defects in organic materials, as they appear as slight deviations in the absorption frequency in the THz region.     

A current-sensed high-speed and low-power first-in-first-out memoryusing a wordline/bitline-swapped dual-port SRAM cell

First-in-first-out (FIFO) data storages are in great demand for telecommunication LSIs. This paper presents high-speed and low-power CMOS memory techniques specialized for FIFO operation. A size-configurable architecture using the tile methodology is employed to customize the word counts and/or data bits with a. short time of less than 30 min. Four flag bits are introduced to inform the internal state of FIFO memories. To obtain a higher operating speed, an SRAM-like memory cell with current-sense readout is used. The critical-path delay of the Gray-code up/down counter, indicating the stored data volume, is shortened to 6.0 ns (66%) by using a double-rail single-stage XOR circuit. As to the low-power techniques, a wordline/bitline-swapped dual-port memory-cell architecture is proposed to cut off the static power-supply current of unselected columns. By using the hidden blanket-precharged bitline scheme, the power dissipation of the writing circuitry is minimized without degrading the operating speed. A new data-driven gated-shift-pulse architecture is also proposed to reduce the power dissipation of shift-register-type address pointers (1.5 mW at 100 MHz). A 2K-words × 8-bits FIFO memory test chip, fabricated with a 0.6-μm CMOS process (a short effective channel length of 0.35 μm is available for both the nMOS and pMOS), has demonstrated the 140-MHz operation at a typical 3.3-V power supply. The power dissipation in standby is less than 0.1 μW and that at 100-MHz dual-port operation with single fan-out loads is in the range from 28 mW (in the best case with the M-scan test pattern) to 46 mW (in the worst case with the checkerboard test pattern)     

Potentiation of paclitaxel cytotoxicity by inostamycin in human small cell lung carcinoma, Ms-1 cells

A robust new analytical method has been developed for the determination of 5-fluorouracil (5-FU) in human plasma samples using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The method is based on a liquid-liquid extraction procedure, precolumn derivatization, reversed-phase HPLC separation, and detection using atmospheric pressure chemical ionization and selected reaction monitoring. The derivatization agent used was 4-bromomethyl-7-methoxycoumarin. The internal standard for the assay procedure was a stable isotope labeled analog of 5-FU. The lower limit of quantitation was 1.0 ng/mL using 500 microL aliquots of plasma. Sample throughput on the mass spectrometer was approximately 17 samples/h (3.5 min/sample). The method was fully validated. The recovery of 5-FU averaged 76.1%. The accuracy of the assay, assessed from quality control samples, ranged from 99.1% to 104.3% (% theoretical). The overall interassay precision (% RSD) was 2.7%, and the intraassay precision (% RSD) ranged from 1.5% to 3.9%. The derivatized samples were found to be stable under sample analysis conditions and during refrigerator storage. The method was specific for the determination of 5-FU.     

Scalability and Performance Analysis of Multi-Level Hierarchy in IP Micro-Mobility Management

This paper presents a study on the benefits of multi-level hierarchy for scalable mobility management in the wireless mobile IP context. Micro-mobility management is considered. The analysis took advantage of the locality in movement and call activities of mobile users. It was discovered that whether multi-level hierarchy is beneficial or not depends on the type of address management employed in the mobility management. When hierarchical addressing structure is used in a micro-mobility region, the system scales with more levels of hierarchy, but if the address structure used is not hierarchical, multi-level hierarchy is less scalable because the root node presents a bottleneck to the system.     

A Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level

Phosphopantetheinylation is an essential post‐translational protein modification to primary and secondary metabolic pathways that ensures bacterial cell viability and virulence, and it is used in the production of many pharmaceuticals. Traditional methods have not provided a comprehensive understanding of these modifications. By using chemical proteomic probes for adenylation and thiolation domains in nonribosomal peptide synthetases (NRPSs), chemoproteomics has been applied to survey and validate the cellular activity of 4‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]‐N‐(4‐methoxypyridin‐2‐yl)piperazine‐1‐carbothioamide (ML267), which is a potent and selective small‐molecule 4′‐phosphopantetheinyl transferase (PPTase) inhibitor that attenuates secondary metabolism and viability of bacterial cells. ML267 inhibited Sfp‐type PPTase and antagonized phosphopantetheinylation in cells, which resulted in a decrease in phosphopantetheinylated NRPSs and the attenuation of Sfp‐PPTase‐dependent metabolite production. These results indicate that this chemoproteomics platform should enable a precise interpretation of the cellular activities of Sfp‐type PPTase inhibitors.     

Improvement of Cogging Thrust in Permanent‐Magnet‐Type Linear Synchronous Motors

This paper presents a method for reducing cogging thrust in permanent‐magnet‐type linear synchronous motors. A phase shift method and supplement tooth method are proposed. The methods do not affect the original thrust performance of the linear motor, nor do they greatly modify its basic shape. The methods are confirmed through experiments and FEM analysis. This paper also discusses the effect of construction errors on cogging thrust.     

Thermal comfort and productivity - Evaluation of workplace environment in a task conditioned office

The environment of workplace in an office involved in creative work was evaluated in 2005 and 2006. The M Company has installed partition based task/ambient conditioning systems (TAC) and several environment-friendly systems, such as double-skin and thermal-storage structures. It was intended to investigate the influence of the worker's behavior and task conditioning on worker's thermal comfort and productivity. In this survey, immediate thermal environment and worker's behavior were measured, and occupants' surveys of thermal comfort and feeling of fatigue were conducted. We found that both activity level of occupant and exposed thermal environment is greatly different one by one. It is suggested that an increase in metabolic rate according to worker's behavior influenced on their thermal comfort. Based on the knowledge obtained from this investigation, needs for TAC are discussed.     

The effect of nanotube alignment on stress graphitization of carbon/carbon nanotube composites

Carbon nanotubes, when used as filler in a glass-like carbon matrix, has been reported to induce stress graphitization in the matrix. The effects on stress graphitization of the amount of carbon nanotube loading and nanotube orientation in the composite were investigated through microscopy and X-ray diffraction analyses. Results showed that an increase in nanotube content and nanotube alignment could increase the extent of formation of anisotropic regions, thereby hastening stress graphitization. It was shown that the distance between nanotubes could affect the formation of the anisotropic structures, such that they could develop in a circumferential manner around the nanotubes when the nanotubes are situated far from each other or develop continuous regions between nanotubes when they are closer together. The development of these microstructures and its relationship to the residual stresses that accumulate in the material during heat treatment is discussed here.