Application of proteomic analysis to renal disease in the clinic

Chronic kidney disease accounts for a significant portion of many national health-care budgets. In this viewpoint, we highlight recent advances in urinary proteomic analyses that potentially may soon enhance the care of afflicted patients. To achieve this goal, cooperation of interdisciplinary teams from around the world will be vital, so as to standardize methodology for preparation urine samples and technical aspects of the analyses, and for better application of results. These collaborative activities will facilitate translational research in kidney diseases.     

Solid-State Polymerization Behavior of 1,3-Bis(3-quinolyl)-1,4-butadiyne

Summary 1,4-Bis(3-quinolyl)-1,3-butadiyne (DQ) is known to be polymerized in solid state to give the corresponding polydiacetylene. However, the polymer yield of DQ bulk crystals is low. Thus, we prepared several types of DQ crystals by different procedures to find the reason for the low polymer yield. We found three modifications of DQ crystals and they were evaluated by spectroscopic measurements and X-ray diffraction. DQ bulk crystals (Crystal I) and thermally grown DQ crystals on Crystal I (Crystal II) have the same structure classified to Type A, which gives regular polydiacetylene structure in low polymer yields. DQ crystals grown on glass plates by sublimation (Crystal III) belong to the second modification of Type B. DQ nanocrystals prepared by the reprecipitation method (Crystal IV) are Type B, and thermally grown DQ crystals on nanocrystals (Crystal V) are Type C. Crystals of Types B and C could be polymerized in low yields without showing excitonic absorption of polydiacetylene indicating irregular polymerization other than 1,4-addition. For crystals of Type A, we found that the 1,4-addition polymerization proceeded only in near-surface portions of the crystals. It can be plausibly explained that mobile monomers in the near-surface portion are only able to take part in their polymerization, resulting in low polymer conversion.     

Evaluation of the Fatigue Characteristics of Laser-processed Hot Work Tool Steel Based on Reliability

It is reported that laser-processing is effective to repair the heat checks, which are fine shallow cracks on a surfaceof die-casting dies.     

Current distribution in superconducting multistrands for ac use before and after quenching

A superconducting multistranded cable is used to realize high current capacity for ac use. The critical current value of the cable is reported to be less than the simple summation of the individual critical current value of each strand. The causes for such a degradation of the critical current value have not been revealed. This paper investigates the current distribution in multistrands before and after their quenching by using seven-strand superconducting cable and 7x7 cable. The following experimental results are derived: (1) the quenching is initiated at one strand in the cable; (2) the current in the quenched strand is transferred into the other strands; (3) an avalanche of quenching is induced among the strands; and (4) the central strand is quenched finally among the strands. The critical current values of the 7- and 7 × 7-stranded cables also are measured. These values are in good agreement with the predicted values based on the mutual inductance among the strands. It is concluded that the unbalance of the current distribution in the superconducting multistrands can be one of the promising causes for the degradation of the critical current value.     

Transformation behaviour with thermal cycling in NiTi alloys

The transformation behaviour of NiTi alloys were investigated by differential scanning calorimetry in order to reveal the effects of thermal cycles with the repetition of the transformation. The thermal cycles tend to lower the transformation temperature between the high and low temperature phases and to stabilize the intermediate phase during cooling to result in a two-stage transformation, while the reverse transformation during heating remains a one-stage transformation. Because these effects of the thermal cycles depend on the composition and the deformation, it is thought that defects play an intrinsic role in the complicated behaviour of NiTi alloys.     

Transmission Properties of Translucent Polycrystalline Alumina

Effects of residual pores and optical birefringence on transmission through translucent polycrystalline alumina have been studied with the Mie scattering theory. The in-line and total forward transmissions of the translucent polycrystalline alumina were simulated as a function of porosity, pore radius, and grain size. The model revealed that porosity has a significant effect on both the total forward scattering and the in-line transmission, whereas grain size affects only in-line transmission. The calculated transmittance is in good agreement with the experimental values. The in-line transmission gradually increased with a decrease in grain size, and the effect of birefringence on the total forward transmission is negligible in the visible spectrum. The total forward transmission in the visible spectrum is mainly governed by residual pores.     

Atomically flat diamond (111) surface formation by homoepitaxial lateral growth

A process of homoepitaxial growth of diamond (111) films by microwave plasma-enhanced chemical vapor deposition has been investigated characterizing areas by ex-situ atomic force microscopy. The evolution of surface morphology during a lateral growth of (111) diamond was visualized utilizing a mesa structure as a marker. Lateral growth forms atomically flat surfaces, which show atomically flat terraces over several hundred nm widths and single bilayer steps of (111) diamond.