Neuropsychological and psychosocial effects of the FMR-1 full mutation: Case report of monozygotic twins discordant for the fragile X syndrome.

An extensive evaluation was conducted with 16-yr-old monozygotic twins concordant for the fragile X full mutation but discordant for mental retardation. The clearly affected twin had an IQ score of 47; 77% of her neuropsychological z scores were at least 2 SDs below average. Her sister had an IQ score of 105 and average neuropsychological performance. However, each girl demonstrated relative verbal strengths and visual-spatial weaknesses. Their parents rated each girl as having significant problems with attention, conduct, anxiety-withdrawal, and hyperactivity. The girls did not rate themselves as having significant anxiety. These findings are consistent with group data on females with fragile X and demonstrate the wide range of effects associated with the fragile X full mutation. This case report implicates the importance of a psychosocial phenotype of fragile X independent of cognitive ability level. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Radiale Wärmeleitung in durchströmten Schüttungsrohren

Heat Transport to the Wall of Packed Tubes. Radial conduction of heat in packed tubes has a crucial influence on yield and selectivity of many heterogeneously catalyzed reactions. In spite of many years of intensive research in the field, there are still tremendous discrepancies between correlations of different origin. Even the standard model using two constant heat transport parameters, which was introduced in the fifties and has since become most widely accepted, has been controversially discussed and called into question. The unsatisfactory state of the art has been an incentive for several groups of researchers to take up this old topic once again. Three parallel experimental investigations on heat transport with air flowing in packed tubes of similar dimensions, electrically heated, steam-heated, or water-cooled, were completed in 1991. Comparative evaluation of the results of these three investigations, together with other data from the relevant literature, now provides the first clear answers to some of the questions so controversially discussed in the past.     

Autothermal two-stage gasification of low-density waste-derived fuels

In order to increase the efficiency of waste utilization in thermal conversion processes, pre-treatment is advantageous. With the Herhof Stabilat^® process, residual domestic waste is upgraded to waste-derived fuel by means of biological drying and mechanical separation of inerts and metals. The dried and homogenized waste-derived Stabilat^® fuel has a relatively high calorific value and contains high volatile matter which makes it suitable for gasification. As a result of extensive mechanical treatment, the Stabilat^® produced is of a fluffy appearance with a low density. A two-stage gasifier, based on a parallel-arranged bubbling fluidized bed and a fixed bed reactor, has been developed to convert Stabilat^® into hydrogen-rich product gas. This paper focuses on the design and construction of the configured laboratory-scale gasifier and experience with its operation. The processing of low-density fluffy waste-derived fuel using small-scale equipment demands special technical solutions for the core components as well as for the peripheral equipment. These are discussed here. The operating results of Stabilat^® gasification are also presented.     

Kommentar I

Ohne Zusammenfassung     

The relationship between optical guiding and the relative phase infree-electron lasers

The relative phase in this case is defined as the shift in the wavenumber from the vacuum value integrated over the interaction length. The relative phase is studied from the standpoint of the linear stability analysis in both the high- and low-gain regimes, and the qualitative implications in each of these regimes of the relative phase on the refractive guiding of the signal are identical. Specifically, the relative phase is found to be negative at the low-frequency end of the gain band. The relative phase increases with increasing frequency over this band until it turns positive at a frequency approximately 10% below the frequency of peak gain. Thus optical guiding is indicated over a large portion, but not all, of the gain band. The specific example of interest involves the low-gain regime prior to saturation. In this case, it is shown that the analytic result is in substantial agreement with the calculation of the relative phase     

Germicidin, an autoregulative germination inhibitor of Streptomyces viridochromogenes NRRL B-1551

During germination spores of Streptomyces viridochromogenes NRRL B-1551 excrete a compound, germicidin, which has an inhibitory effect on the germination of its own arthrospores at a concentration as low as 200 pM (40 pg/ml). At higher concentrations germicidin inhibits porcine Na+/K(+)-activated ATPase and retards the germination of the cress Lepidium sativum. Germicidin is the first known autoregulative inhibitor of spore germination in the genus Streptomyces and was isolated from the supernatant of germinated spores, but also from the supernatant of the submerged culture. Spectroscopic analysis and derivatization reactions revealed germicidin to be 6-(2-butyl)-3-ethyl-4-hydroxy-2-pyrone (C11H16O3). Crude isolates of germicidin from the supernatant of submerged culture, but not from the spores, contained a second, structurally very similar compound (C10H14O3), in which in contrast to germicidin a 2-propyl instead of the 2-butyl chain was bound to C-6 and which did not show any activity in the germination and ATPase assay. The germination assay was evaluated as a new screening model for specifically active compounds.     

Selectivity in Methanol Oxidation as Studied on Model Systems Involving Vanadium Oxides

Oxidation catalysts are modeled by oxide single crystals, thin oxide films, as well as supported oxide nanoparticles. We characterize the surface of those materials using a variety of surface sensitive techniques including scanning tunneling microscopy and spectroscopy, photoelectron spectroscopy, infrared spectroscopy, and thermal desorption spectroscopy. We find temperature dependent structural transformations from V₂O₅(001) to V₂O₃(0001) via V₆O₁₃(001). V₂O₃(0001) is found to be vanadyl terminated in an oxygen ambient and it loses the vanadyl termination after electron bombardment. It is shown that the concentration of vanadyl groups controls the selectivity of the methanol oxy-dehydrogenation towards formaldehyde. A proposal for the mechanism is made. The results on single crystalline thin films are compared with similar measurements on deposited vanadia nanoparticles. The experimental results are correlated with theoretical calculations and models.     

Co-Channel Operation of Macro- and Femtocells in a Hierarchical Cell Structure

In this paper, the feasibility of user-deployed femtocells in the same frequency band as an existing macrocell network is investigated. Key requirements for co-channel operation of femtocells such as auto-configuration and public access are discussed. Methods for femtocell power auto-configuration that ensure a constant cell radius in the downlink, and a low pre-definable interference impact on co-channel macrocells in the uplink are proposed. The theoretical performance of randomly deployed femtocells in such a hierarchical cell structure and the resulting impact on existing co-channel macrocells is analysed for a cellular UMTS network using system level simulations.     

Impact of the floating-point precision and interpolation scheme on the results of DNS of turbulence by pseudo-spectral codes

In this paper we investigate the impact of the floating-point precision and interpolation scheme on the results of direct numerical simulations (DNS) of turbulence by pseudo-spectral codes. Three different types of floating-point precision configurations show no differences in the statistical results. This implies that single precision computations allow for increased Reynolds numbers due to the reduced amount of memory needed. The interpolation scheme for obtaining velocity values at particle positions has a noticeable impact on the Lagrangian acceleration statistics. A tri-cubic scheme results in a slightly broader acceleration probability density function than a tri-linear scheme. Furthermore the scaling behavior obtained by the cubic interpolation scheme exhibits a tendency towards a slightly increased degree of intermittency compared to the linear one.