金华历史文化名城保护

本文较为详细地叙述了浙江金华历史文化名城的资源存在状况、保护价值、保护内容和主要文物单位及保护范围等。     

Influence of CYP3A5 polymorphism on tacrolimus blood concentrations in renal transplant patients

Objective Tacrolimus is an immunosuppressive drug with narrow therapeutic range and wide interindividual variation in its pharmacokinetics. Tacrolimus is a substrate of cytochrome P450(CYP)3A5. The aim of this study was to evaluate whether the A6986G polymorphism is associated with tacrolimus concentration /dose ratio. Methods Fifty-two Chinese renal transplant patients were enrolled in this study. Their body weight, dosage and concentration of tacrolimus were observed. CYP3A5 genotype was determined by polymerase chain reaction followed by restriction fragment length polymorphism analysis. Results A significant association was found between tacrolimus levels per dose/kg/d and CYP3A5 gene A6986G polymorphism (P<0.001). The CYP3A5 * 3 * 3 patients have a significantly higher tacrolimus level/dose than CYP3A5 * 1 * 1 and CYP3A5 * 1 * 3. Conclusions CYP3A5 gene A6986G polymorphism is associated with tacrolimus pharmacokinetics and dose requirements. Pharmacogenetic methods could be employed prospectively to help the dose selection and to individualize immunosuppressive therapy according to the result. Foundation item: Project (03GZ3072) supported by the Science and Technology Department of Hunan Province; project (2004035206) supported by the China Postdoctoral Foundation and project (30300383) supported by the National Natural Sciences Foundation of China     

Direct adaptive control of nonminimum phase systems using integralaction

A direct adaptive control scheme is proposed for nonminimum-phase systems in which controller parameters are estimated from the recursive least-squares algorithm and additional auxiliary parameters are obtained from the proposed polynomial identity. A local convergence is guaranteed without any extra condition. Integral action is incorporated into the adaptive controller to eliminate the steady-state error and to satisfy a condition of the unique solution for the polynomial identity. The control law used in this scheme is based on the set-point-on-I-only proportional-integral-derivative (PID) structure     

Re-examination of analytical models for microwave scattering from deciduous leaves

This paper presents an examination of classical scattering models for radar cross sections of deciduous leaves, such as the generalised Rayleigh-Gans (GRG) model and the physical optics (PO) model. The PO model employs the resistive sheet approximation in this study. The validity regions of the analytical models for microwave scattering from deciduous leaves are investigated by comparison with the precise numerical results of the method of moment. It was found that the GRG and PO models extend their validity regions for estimating the scattering amplitudes as the thickness of a lossy dielectric disk decreases. The GRG and PO models can be used alternatively for computing the scattering matrices of natural deciduous leaves at microwave frequencies regardless of the size of the leaves, because of the very small thickness of the leaves (0.2-0.4 mm)     

基于移动代理的安全研究

移动代理计算模式较传统的分布式计算模式有明显的优势,而伴随它有诸多安全问题出现,这使得它没有得到十分广泛的应用。本文针对代理自身的安全问题,分析了代理可能受到的攻击,并提出了一个安全方案。     

神经网络在缺陷识别中的应用

为了准确、快速地进行缺陷识别，介绍了一种新型的前馈神经网络模型，即径向基概率神经网络。与以往的算法相比，该方法具有分类识别精度高且速度快的优点。仿真获得了很好的结果。