Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions

We investigated clinical efficacy of green tea extracts (polyphenon E; poly E and (-)-epigallocatechin-3-gallate [EGCG]) delivered in a form of ointment or capsule in patients with human papilloma virus (HPV) infected cervical lesions. Fifty-one patients with cervical lesions (chronic cervicitis, mild dysplasia, moderate dysplasia and severe dysplasia) were divided into four groups, as compared with 39 untreated patients as a control. Poly E ointment was applied locally to 27 patients twice a week. For oral delivery, a 200 mg of poly E or EGCG capsule was taken orally every day for eight to 12 weeks. In the study, 20 out of 27 patients (74%) under poly E ointment therapy showed a response. Six out of eight patients under poly E ointment plus poly E capsule therapy (75%) showed a response, and three out of six patients (50%) under poly E capsule therapy showed a response. Six out of 10 patients (60%) under EGCG capsule therapy showed a response. Overall, a 69% response rate (35/51) was noted for treatment with green tea extracts, as compared with a 10% response rate (4/39) in untreated controls (P<0.05). Thus, the data collected here demonstrated that green tea extracts in a form of ointment and capsule are effective for treating cervical lesions, suggesting that green tea extracts can be a potential therapy regimen for patients with HPV infected cervical lesions.     

Blends of a chlorinated poly(vinyl chloride) compound and a thermotropic liquid crystalline copolyester: Mechanical properties of squeezed flow films

The mechanical properties of squeezed flow films were measured on blends of a chlorinated poly(vinyl chloride) (CPVC) compound and a thermotropic liquid crystalline copolyester of p-hydroxybenzoic acid/poly(ethylene terephthalate) (60/40), hereafter referred to as LCC. CPVC is immiscible with LCC. The most serious and unique problem of liquid crystalline polymers is their tendency to fibrillate when fabricated into films and injection molded parts, primarily because of a high degree of mechanical anisotropy. It has been found that the mechanical anisotropy of LCC and blends could be lessened using nonisothermal squeezing equibiaxial extension flow. The maximum tensile properties of LCC are achieved when processed in the vicinity of 260°C. For blends of CPVC containing LCC, the mechanical properties are dependent on the processing temperature and compositions. Blends with no more than 20 wt% of LCC exhibit significant increases in tensile properties. This is due to the possibility of frozen-in macroscopic biaxial orientation of LCC in the blends during the nonisothermal squeezing flow. Within the range of processable temperatures, the reinforcement of CPVC due to the incorporation of LCC can be achieved at a temperature below the optimum processing temperature of LCC, although the thermal history of blends never reaches that temperature.     

Smart computational fracture of materials and structures

The use of the finite element method for complex engineering problems is now common. To ease the burden on the engineer the development of smart or adaptive computational methods is now required to model complex problems. In this paper we investigate the development of an adaptive finite element method for fracture-related problems. The adaptive method involves various stages which include the finite element analysis, error estimation/indication, mesh refinement and fracture/failure analysis in a loop. Some simple error estimators, based on stress projection, are used to investigate the adaptive finite element process. Element refinement is based on three schemes; the first and second are a simple and hierarchical refinement scheme with transitioning which avoids the need for constraint equations between element boundaries. Another scheme based on constraint equations between elements is also examined. The energy norm is used to estimate the element error. The software has the ability to introduce a discrete fracture in the structure according to standard fracture analysis practice. Crack tip parameters are calculated using a least-squares fit of the displacements into the asymptotic crack tip displacement field. Some simple examples are used to investigate the adaptive process, its behavior and some of the practical problems encountered. The convergence and equilibrium of the adaptive process, in terms of global error in the energy norm, are investigated. In the example the same problem is analyzed using both a fine computational grid and a coarse one. The coarse mesh is then adapted using the three different procedures available. The estimated error in the solution and the stress intensity are shown against the number of elements and number of iterations. Some further areas of research in adaptive finite element analysis are discussed.     

Adaptation of drafting plotter for buried contact groove formation

Lasers (e.g. Nd-YAG) have been used extensively for groove formation both in laboratories and commercial production but the initial capital cost is high. The production throughput is also low and thus adds to the cost of the cell. To reduce cost and increase production throughput a drafting plotter has been adapted to serve as a mechanical scriber for groove formation. The adapted plotter can scribe cells in matrix form to reduce the human labour and increase the production throughput. The characterization of the scribing tips in conjunction with the plotter showed that the best yield for the scriber is obtained when the scribing tip is mounted at 78° to the stock. Of the seven characterized scribing tips, the 90° conical scriber has been found to give the same groove geometry as the laser. The application of the adapted plotter to cell fabrication did not show any significant deterioration in the electrical output parameters for the mechanically scribed cells when compared with laser scribed cells. This article reports the adaptation of the x-y table drafting plotter to form buried contact grooves.     

The material properties of sulphonated phenolic resin reinforced cement mortars

The material properties of new sulphonated phenolic resin (SP) reinforced cement mortars have been investigated. SP was found to promote the dispersion of cement particles and to interact with Ca(OH)₂. As a result, the resulting mortars exhibit better workability, more compact structure and higher compressive strength than plain mortars. The mortar with 1 wt% SP present after 28 days curing exhibits a compressive strength of 66MPa, which is about 18% higher than that of plain mortar.     

Queueing analyses of traffic access control strategies withpreemptive and nonpreemptive disciplines in wideband integrated networks

A multiserver queueing model of access control strategies for a wideband integrated services digital network (ISDN) is considered. There are two types of service requests (SRs): Type 1 SR requires b servers (basic bandwidth units, BBUs) of the c available servers, while Type 2 SR requires a single server. Both types of SRs are queuable in two separate infinite-size buffers. A Type 1 SR is allowed to seize d(⩽b) servers at first and then acquire additional servers as they become available to meet the original requirement of b servers. The arrival processes of both types of SRs are Poisson and the service times are exponentially distributed with mean b/dμ₁ and 1/μ₂ for Type 1 SR and Type 2 SR, respectively. Preemptive and nonpreemptive priority disciplines with movable boundary are analyzed using the Neuts' matrix-analytic approach. Numerical examples of the queue length distribution and the mean waiting time of the SRs are presented     

Computational study of packing a collagen-like molecule: quasi-hexagonal vs "Smith" collagen microfibril model

The lateral packing of a collagen-like molecule, CH3CO-(Gly-L-Pro-L-Pro)4-NHCH3, has been examined by energy minimization with the ECEPP/3 force field. Two current packing models, the Smith collagen microfibril twisted equilateral pentagonal model and the quasi-hexagonal packing model, have been extensively investigated. In treating the Smith microfibril model, energy minimization was carried out on various conformations including those with the symmetry of equivalent packing, i.e., in which the triple helices were arranged equivalently with respect to each other. Both models are based on the experimental observation of the characteristic axial periodicity, D = 67 nm, of light and dark bands, indicating that, if any superstructure exists, it should consist of five triple helices. The quasi-hexagonal packing structure is found to be energetically more favorable than the Smith microfibril model by as much as 31.2 kcal/mol of five triple helices. This is because the quasi-hexagonal packing geometry provides more nonbonded interaction possibilities between triple helices than does the Smith microfibril geometry. Our results are consistent with recent x-ray studies with synthetic collagen-like molecules and rat tail tendon, in which the data were interpreted as being consistent with either a quasi-hexagonal or a square-triangular structure.     

Analysis and design-optimization of LCC resonant inverter forhigh-frequency AC distributed power system

The analysis and design of an LCC resonant inverter for a 20 kHz AC distributed power system are presented. Several resonant converter topologies are assessed to determine their suitability for high efficiency power conversion, under resistive and reactive loads. Two LCC-resonant inverter designs were implemented. One with all switches operating with zero voltage switching (ZVS), and another with two switches operating with ZVS and two switches with zero current switching (ZCS). The experimental results are presented along with a performance comparison of the two versions