Oxidative Stress and Chemoradiation-Induced Oral Mucositis: A Scoping Review of In Vitro,In Vivo and Clinical Studies

Chemoradiation-induced mucositis is a debilitating condition of the gastrointestinal tract eventuating from antineoplastic treatment. It is believed to occur primarily due to oxidative stress mechanisms, which generate Reactive Oxygen Species (ROS). The aim of this scoping review was to assess the role of oxidative stress in the development of Oral Mucositis (OM). Studies from the literature, published in MEDLINE and SCOPUS, that evaluated the oxidative stress pathways or antioxidant interventions for OM, were retrieved to elucidate the current understanding of their relationship. Studies failing inclusion criteria were excluded, and those suitable underwent data extraction, using a predefined data extraction table. Eighty-nine articles fulfilled criteria, and these were sub-stratified into models of study (in vitro, in vivo, or clinical) for evaluation. Thirty-five clinical studies evaluated antioxidant interventions on OM’s severity, duration, and pain, amongst other attributes. A number of clinical studies sought to elucidate the protective or therapeutic effects of compounds that had been pre-determined to have antioxidant properties, without directly assessing oxidative stress parameters (these were deemed “indirect evidence”). Forty-seven in vivo studies assessed the capacity of various compounds to prevent OM. Findings were mostly consistent, reporting reduced OM severity associated with a reduction in ROS, malondialdehyde (MDA), myeloperoxidase (MPO), but higher glutathione (GSH) and superoxide dismutase (SOD) activity or expression. Twenty-one in vitro studies assessed potential OM therapeutic interventions. The majority demonstrated successful a reduction in ROS, and in select studies, secondary molecules were assessed to identify the mechanism. In summary, this review highlighted numerous oxidative stress pathways involved in OM pathogenesis, which may inform the development of novel therapeutic targets.     

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佛山岭南明珠体育馆

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密闭空间内六硝基六氮杂异伍兹烷基复合炸药能量释放特性

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红外干扰弹及其发展

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光折变多量子阱的电吸收栅和电折变栅

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镁离子催化下2-(二硝基亚甲基)-1,3-二氮环戊烷的合成

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装甲车辆齿轮箱故障诊断中的信息增强技术

利用时域平均技术完成对周期信号的提取，通过对信号的内插处理、解调分析、重新抽样和时域平均，完成对轴频信号和啮频信号的提取；通过对故障信号特点的研究，提出了故障信息增强方法，给出了故障敏感因子。通过对装甲车辆齿轮传动箱振动加速度信号测试结果分析，得到了良好的效果。与未采用故障信息增强方法相比，不仅提高了信号的信噪比，而且提高了故障信息。     

基于TPC的大气无线光通信差错性能分析

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