Chemical Factors Underlying the More Rapid β-O-4 Bond Cleavage of Syringyl than Guaiacyl Lignin under Alkaline Delignification Conditions

This study aimed to clarify why the β-O-4 bond cleavage of syringyl lignin is more rapid than that of guaiacyl lignin under alkaline pulping conditions. We examined whether or not three chemical factors, acidity of the α-hydroxy group, nucleophilicity of the generated α-alkoxide, and leaving ability of the leaving phenoxide, are different between syringyl and guaiacyl lignins and control the rate of the alkaline-induced β-O-4 bond cleavage, employing dimeric non-phenolic β-O-4-type lignin model compounds (LMCs) and novel methods for estimating these three factors. The results indicated that the α-hydroxy groups of syringyl-type LMCs are relatively more acidic than those of guaiacyl-type and that syringyl nucleus is a better leaving group than guaiacyl nucleus in the β-O-4 bond cleavage. These factors result in the β-O-4 bond of syringyl lignin being more prone to the alkaline-induced cleavage than that of guaiacyl lignin.     

Seismic proof test of a reinforced concrete containment vessel (RCCV): Part 1: Test model and pressure test

In Japan, the Nuclear Power Engineering Corporation (NUPEC), sponsored by the Ministry of Economy, Trade and Industry (METI), has been conducting a series of seismic reliability proving tests using full-scale or close to full-scale models to simulate actual important equipment that is critical for seismic safety of nuclear power plants. The tests are intended to validate the seismic design and reliability with a sufficient margin even under destructive earthquakes. A series of tests was carried out on a reinforced concrete containment vessel (RCCV) for advanced boiling water reactor (ABWR) from 1992 to 1999. A large-scale high-performance shaking table at Tadotsu Engineering Laboratory, the largest in the world, was used for this test. Part 1 reports the test model and the results of pressure and leak tests. Part 2 describes test procedures, input waves and the results of verification tests such as changes of stiffness, characteristic frequency and damping ratio, the failure of the model and the load deflection. Part 3 shows the seismic safety margin that was evaluated from the energy input during the failure test to a design basis earthquake. Part 4 reports simulation analysis results by a stick model with lumped masses.     

Seismic proof test of a reinforced concrete containment vessel (RCCV): Part 2: Results of shaking table tests

A 1/8-scale model was constructed of a reinforced concrete containment vessel (RCCV) used in the latest advanced boiling water reactors (ABWR). Shaking table tests were conducted on it with input motions corresponding to or exceeding a design earthquake assumed for a real Nuclear Power Plant.The objectives of the tests were to verify the structural integrity and the leak-proof functional soundness of the RCCV subjected to design earthquakes, and to determine the ultimate strength and seismic margin by an excitation that led to the model's collapse. The model, the test sequence and the pressure and leak test results were addressed in Part 1. The shaking table test method, the input motions and the test results, including the transition of the model's stiffness, natural frequencies and damping factors and the effects of vertical input motions and internal pressure on the model's characteristics and behavior, the load–deformation, the ultimate strength, the failure mode of the reinforced concrete portion and the liner plate are described here. The seismic safety margin that was evaluated by the energy input during the failure test to a design basis earthquake will be described in Part 3. The analytical results of simulation using the multi-lumped mass model will be described in Part 4.     

Augmented proliferation of human alveolar macrophages after allogeneic bone marrow transplantation

After allogeneic bone marrow transplantation (allo-BMT), recipient alveolar macrophages (AM) are gradually replaced by AM of the donor origin. An influx of mononuclear phagocytes of donor origin to the lung is responsible for the repopulation, but the detailed kinetics remain unclear. We therefore studied 24 BMT recipients who underwent bronchoalveolar lavage (BAL) from 24 to 83 days after BMT. AM cell number, size, morphology, proliferating ability, and genotype of AM were measured. Before day 50, the number and size of AM in BAL fluid were similar to those of normal nonsmokers. However, after day 50, the mean number of AM increased threefold and the mean cell size decreased due to the increase of small AM. These small cells are presumably of donor origin based on DNA fingerprinting analysis and based on fluorescence in situ hybridization for the Y chromosome in a sex-mismatched case. Immunohistochemistry and cell cycle analysis demonstrated that the increase in AM number coincided with a remarkable increase of AM expressing proliferating cell nuclear antigen, suggesting that small AM are proliferating. This is the first report representing that augmented proliferation of donor AM in situ may contribute to the reconstitution of AM population after BMT.     

Digital fault location for high resistance grounded transmissionlines

This paper demonstrates that the presence of multiple load taps cannot be neglected for single-phase-to-ground fault location. A new method has been developed taking this into consideration, that can be applied to correct the location error due to intermediate power sources. Then fault location methods for parallel double-circuit two-terminal transmission lines are discussed. Finally, a new fault location method is proposed for high-resistance grounded double-circuit transmission lines with three terminals     

Motion of 2D Buoyant Clouds Downslope

The motion of conservative 2D thermals on beds with slope angles θ ranging from 5 to 90° is investigated theoretically and experimentally. Using a large number of experimental data, important flow characteristics, including the shape factors, spatial growth rate, propagation speed, and entrainment coefficient, are quantified as functions of bottom slope angles. A thermal model, which includes a resistance term, is developed. It is found semiempirically that resistance coefficients Cd are almost independent of θ and the values of Cd are in the range of 0.4–0.6. Capability of the model is demonstrated by comparing numerical results with theoretical as well as experimental results.     

Polarization potentials causing pacemaker oversensing

This case of ectopic pancreas found in the pre-pyloric channel of a 2-day-old infant is unique. A review of the literature reveals no other cases of symptomatic ectopic pancreas in an infant of this age. In this patient, signs and symptoms were consistent with pyloric stenosis. Upper gastrointestinal study and esophagogastroduodenoscopy (EGD) revealed the diagnosis. This case is examined and the literature is reviewed.     

Syntheses and antitumor activity of cis-restricted combretastatins: 5-membered heterocyclic analogues

A series of cis-restricted combretastatin analogues with 5-membered heterocycles were synthesized and their inhibitory activity against microtubule assembly and cytotoxic activity against the colon 26 adenocarcinoma cancer cell line were evaluated. Some of the heterocyclic analogues showed potent antitubulin activity and cytotoxicity. Compounds 16 and 35 showed marked tumor growth suppression in the colon 26 murine tumor model.     

A new choleretic effect of folinic acid

BACKGROUND/AIMS: In the chemotherapy of recurrent gastric cancer with 5-fluorouracil and folinic acid, an interesting phenomenon, the reduction of jaundice and improvement of liver function, was observed. The aim of this study was to investigate the mechanism of this phenomenon, and to confirm a choleretic effect of folinic acid. METHODOLOGY: The bile duct of anesthetized rats was catheterized, and bile was collected. Bile volume and total bile acid production following intraperitoneal administration of folinic acid were determined and compared to those of control rats. RESULTS: Both bile volume and total bile acid production increased following intraabdominal administration of folinic acid. CONCLUSIONS: Folinic acid has a newly described pharmacologic effect of stimulating bile acid-dependent choleresis. It is possible that folinic acid may become a new drug for the treatment of jaundice or for the improvement of overall liver function.