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991.
992.
Matrix metalloproteinases are thought to be key players in the remodelling activity of cells associated with both physiological and pathological processes. They share a relatively conserved structure with a number of identifiable modules linked to their specific functions. The structure of the individual domains of a number of matrix metalloproteinases have now been elucidated. Here we review these data in the light of complementary studies on the behaviour of these enzymes in biological systems. In particular we focus on the C-terminal hemopexin-like domain which has intriguingly specific roles in individual matrix metalloproteinases. 相似文献
993.
M Zawadzka B Barański J Wi?niewska-Knypl T Wrońska-Nofer 《Canadian Metallurgical Quarterly》1993,6(4):391-397
Genotoxic effect and hepatic microsomal monooxygenase activities were assessed in mice treated with Acid Green 16 (single i.p. injection at dose 75 mg/kg) superimposed on prolonged ethanol consumption (10% solution in drinking water for 2-4 months). Treatment of mice with Acid Green 16 led to an increased frequency of micronucleated erythrocytes in bone marrow. In animals pretreated with ethanol the frequency of micronucleated erythrocytes, produced by Acid Green 16, was significantly higher. The changes in frequency of micronucleated erythrocytes were accompanied by the enhanced activity of microsomal monooxygenases manifested by higher activity of 7-ethoxycoumarin o-deethylase (the level of cytochrome P-450 was not altered). The obtained results showed that ethanol tended to increase the genotoxic effect of Acid Green 16. However, the slight inductive effect of ethanol on microsomal monooxygenases did not provide clear evidence that the genotoxic effect of Acid Green 16 was associated with ethanol stimulation of the metabolic activation of the dye in the liver. 相似文献
994.
卸荷裂隙在水利水电工程建设中的危害 总被引:3,自引:0,他引:3
卸荷裂隙是对水工建筑物稳定最不利的软弱结构面之一。文中较系统地介绍了这种结构面的特点、分布规律、形成的力学机理、对工程的危害、勘查方法及处理措施。 相似文献
995.
996.
Reports an error in "Current issues relating to psychosocial job strain and cardiovascular disease research" by T?res Theorell and Robert A. Karasek (Journal of Occupational Health Psychology, 1996[Jan], Vol 1[1], 9-26). On p. 12, in the caption to Figure 2, the copyright statement is missing. The caption should have read "The environment, the worker, and illness: Dynamic associations linking environmental strain and learning to evolution of personality. From Healthy Work: Stress, Productivity, and the Reconstruction of Working Life (p. 99), by R. A. Karasek and T. Theorell, 1990, New York: Basic Books. Copyright 1990 by Basic Books. Used with permission." (The following abstract of the original article appeared in record 1996-04477-002.) Examines recent reviews of cardiovascular (CV) job strain (JS) research by P. L. Schnall and P. A. Landsbergis (1994) and T. S. Kristensen (see record 1995-39109-001), which conclude that JS as defined by the demand-control model (the combination of contributions of low job decision latitudes and high psychological job demands) is confirmed as a risk factor for CV mortality in a large majority of studies. Lack of social support at work appears to increase this risk. Several still-unresolved issues are discussed in light of recent research. Methodological issues related to the use of occupational & career aggregate estimates, use of standard scales for job analysis, and recall bias in issues of self-reporting are examined. Confounding factors and differential strengths of associations by subgroups in JS-CV disease analyses with respect to social class, gender, and working hours are addressed. A review of results of monitoring JS-blood pressure associations and associated methodological issues is provided. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
997.
The dependence between the activity parameters of muscarine antagonists in the prevention of haloperidol catalepsy in rats and those in tests characterizing the interaction of ligands and various subtypes of m-cholinoceptors was studied. It was established by constructing the mathematical dependence that blockade of m1-cholinoceptors increases, while that of m2-cholinoceptors reduces the antiparkinsonian activity of the drugs. The activity of the muscarine antagonist pentiphan in the prevention of haloperidol-induced catalepsy in rats exceeds the activity of such traditional antiparkinsonian drugs as cyclodol and amedin. 相似文献
998.
999.
1000.
Zhang Haiqi 《Scientometrics》1996,37(1):177-190
Research activities in the life sciences during the past few years, have increased appreciably in China, both in regard to relative output of publications and in their impact on the international research community. The purpose of this study is to analyze and evaluate quantitatively the scientific productivity of key medical universities in China by using CBMdisc, MEDLINE and SCI databases. The results showed that Tongji Medical University ranks first in terms of paper output in Chinese and in English languages, while Beijing Medical University is placed second in output but is first in citation impact. Shanghai Medical University had the top annual paper output per scientist, with 2.53 papers in Chinese and 0.13 papers in English. The results also showed that the coverage of Chinese biomedical publications by western indexing services is very poor. 相似文献