HLA-DRB1 genes and disease severity in rheumatoid arthritis. The MIRA Trial Group. Minocycline in Rheumatoid Arthritis

OBJECTIVE: To examine the effect of alleles encoding the "shared"/"rheumatoid" epitope on rheumatoid arthritis (RA) disease severity in patients who participated in the minocycline in RA (MIRA) trial. METHODS: Of 205 patients with a week-48 visit, blood was available for typing of HLA-DRB1 and HLA-DQB1 in 174 (85%) and successfully completed in 169 (82%). Baseline erosions were used to assess disease severity and new erosions at the last visit served as a proxy for progression. RESULTS: At baseline, there was no association between the presence of erosive disease or rheumatoid factor status and the dose of rheumatoid epitope (homozygous, heterozygous, none) or the specific alleles identified. At the final visit, a gradient was observed for the 3 allelic subgroups (and their gene doses) in the occurrence of new erosions among the Caucasian placebo-treated, but not the minocycline-treated, patients. A treatment group/HLA-DR4 epitope interaction was demonstrated in multivariate analyses. Approximately two-thirds of African-American patients did not have the rheumatoid epitope. CONCLUSION: HLA-DRB1 oligotyping may be useful in predicting the progression of disease in some Caucasian patients. Our study corroborates the infrequency of the epitope among African-American patients with RA.     

Hands-free administration of subjective workload scales: Acceptability in a surgical training environment

Introduction

Subjective workload measures are usually administered in a visual-manual format, either electronically or by paper and pencil. However, vocal responses to spoken queries may sometimes be preferable, for example when experimental manipulations require continuous manual responding or when participants have certain sensory/motor impairments. In the present study, we evaluated the acceptability of the hands-free administration of two subjective workload questionnaires - the NASA Task Load Index (NASA-TLX) and the Multiple Resources Questionnaire (MRQ) - in a surgical training environment where manual responding is often constrained.

Method

Sixty-four undergraduates performed fifteen 90-s trials of laparoscopic training tasks (five replications of 3 tasks - cannulation, ring transfer, and rope manipulation). Half of the participants provided workload ratings using a traditional paper-and-pencil version of the NASA-TLX and MRQ; the remainder used a vocal (hands-free) version of the questionnaires. A follow-up experiment extended the evaluation of the hands-free version to actual medical students in a Minimally Invasive Surgery (MIS) training facility.

Results

The NASA-TLX was scored in 2 ways - (1) the traditional procedure using participant-specific weights to combine its 6 subscales, and (2) a simplified procedure - the NASA Raw Task Load Index (NASA-RTLX) - using the unweighted mean of the subscale scores. Comparison of the scores obtained from the hands-free and written administration conditions yielded coefficients of equivalence of r = 0.85 (NASA-TLX) and r = 0.81 (NASA-RTLX). Equivalence estimates for the individual subscales ranged from r = 0.78 (“mental demand”) to r = 0.31 (“effort”). Both administration formats and scoring methods were equally sensitive to task and repetition effects. For the MRQ, the coefficient of equivalence for the hands-free and written versions was r = 0.96 when tested on undergraduates. However, the sensitivity of the hands-free MRQ to task demands (η_partial² = 0.138) was substantially less than that for the written version (η_partial² = 0.252). This potential shortcoming of the hands-free MRQ did not seem to generalize to medical students who showed robust task effects when using the hands-free MRQ (η_partial² = 0.396). A detailed analysis of the MRQ subscales also revealed differences that may be attributable to a “spillover” effect in which participants’ judgments about the demands of completing the questionnaires contaminated their judgments about the primary surgical training tasks.

Conclusion

Vocal versions of the NASA-TLX are acceptable alternatives to standard written formats when researchers wish to obtain global workload estimates. However, care should be used when interpreting the individual subscales if the object is to make comparisons between studies or conditions that use different administration modalities. For the MRQ, the vocal version was less sensitive to experimental manipulations than its written counterpart; however, when medical students rather than undergraduates used the vocal version, the instrument’s sensitivity increased well beyond that obtained with any other combination of administration modality and instrument in this study. Thus, the vocal version of the MRQ may be an acceptable workload assessment technique for selected populations, and it may even be a suitable substitute for the NASA-TLX.     

Taxonomy,technology and applications of smart objects

Deployment of embedded technologies is increasingly being examined in industrial supply chains as a means for improving efficiency through greater control over purchase orders, inventory and product related information. Central to this development has been the advent of technologies such as bar codes, Radio Frequency Identification (RFID) systems, and wireless sensors which when attached to a product, form part of the product’s embedded systems infrastructure. The increasing integration of these technologies dramatically contributes to the evolving notion of a “smart product”, a product which is capable of incorporating itself into both physical and information environments. The future of this revolution in objects equipped with smart embedded technologies is one in which objects can not only identify themselves, but can also sense and store their condition, communicate with other objects and distributed infrastructures, and take decisions related to managing their life cycle. The object can essentially “plug” itself into a compatible systems infrastructure owned by different partners in a supply chain. However, as in any development process that will involve more than one end user, the establishment of a common foundation and understanding is essential for interoperability, efficient communication among involved parties and for developing novel applications. In this paper, we contribute to creating that common ground by providing a characterization to aid the specification and construction of “smart objects” and their underlying technologies. Furthermore, our work provides an extensive set of examples and potential applications of different categories of smart objects.     

Generic Certificateless Encryption Secure Against Malicious-but-Passive KGC Attacks in the Standard Model

Despite the large number of certificateless encryption schemes proposed recently, many of them have been found insecure under a practical attack, called malicious-but-passive KGC (Key Generation Center) attack. In this work we propose the first generic construction of certificateless encryption, which can be proven secure against malicious-but-passive KGC attacks in the standard model. In order to encrypt a message of any length, we consider the KEM/DEM (key encapsulation mechanism/data encapsulation mechanism) framework in the certificateless setting, and propose a generic construction of certificateless key encapsulation mechanism (CL-KEM) secure against malicious-but-passive KGC attacks in the standard model. It is based on an identity-based KEM, a public key encryption and a message authentication code. The high efficiency of our construction is due to the efficient implementations of these underlying building blocks, and is comparable to Bentahar et al.’s CL-KEMs, which have only been proven secure under the random oracle model with no consideration of the malicious-but-passive KGC attack. We also introduce the notion of certificateless tag-based KEM (CL-TKEM), which is an extension of Abe et al.’ s work to the certificateless setting. We show that an efficient CL-TKEM can be constructed by modifying our CL-KEM scheme. We also show that with a CL-TKEM and a data encapsulation mechanism secure under our proposed security model, an efficient certificateless hybrid encryption can be constructed by applying Abe et al.'s transformation in the certificateless setting.     

Strategy, networks and systems in the global translation services market

The globalisation of markets has led to an increased demand for language translation services that support and enable communication between economic partners. For example, technical documents, software systems, business documents and web sites all need to be translated into multiple languages for individual national markets, and the information that they contain changes periodically. This paper sets out a theoretical framework that describes the architectures of business processes within and between separate firms that are used to support the delivery and management of services. This is done by coordinating the fit between externally generated problem complexity, from customers, and the internally generated complexity of different potential network configuration solutions. The theoretical framework is an architecture of how complexity is generated and managed at the different structural levels and across the different processual stages of an industry. A case study of thebigword, a major international translation services company, illustrates how the framework is applied in practice. The case study analyses the implementation of an electronic market platform which enables the coordination of the different stakeholders involved in the translation services market. These stakeholders include translators, translation services companies and their clients in a global business network.     

An Achilles heel: denial of service attacks on Australian critical information infrastructures

Critical, or national, information infrastructure protection, referred to as either CIIP or NIIP, has been highlighted as a critical factor in overall national security by the United States, the United Kingdom, India and the European Community. As nations move inexorably towards so-called ‘digital economies’, critical infrastructure depends on information systems to process, transfer, store and exchange information through the Internet. Electronic attacks such as denial of service attacks on critical information infrastructures challenge the law and raise concerns. A myriad of issues potentially plague the protection of critical information infrastructures owing to the lack of legal regulation aimed at ensuring the protection of critical information infrastructures. This paper will highlight the legal concerns that relate to the denial of service attacks on critical information infrastructures and provide an introductory overview of the law as it relates to CIIP in Australia.     

<Emphasis Type="Italic">A Midsummer Night’s Dream</Emphasis> (with flying robots)

Seven flying robot “fairies” joined human actors in the Texas A&;M production of William Shakespeare’s A Midsummer Night’s Dream. The production was a collaboration between the departments of Computer Science and Engineering, Electrical and Computer Engineering, and Theater Arts. The collaboration was motivated by two assertions. First, that the performing arts have principles for creating believable agents that will transfer to robots. Second, the theater is a natural testbed for evaluating the response of untrained human groups (both actors and the audience) to robots interacting with humans in shared spaces, i.e., were believable agents created? The production used two types of unmanned aerial vehicles, an AirRobot 100-b quadrotor platform about the size of a large pizza pan, and six E-flite Blade MCX palm-sized toy helicopters. The robots were used as alter egos for fairies in the play; the robots did not replace any actors, instead they were paired with them. The insertion of robots into the production was not widely advertised so the audience was the typical theatergoing demographic, not one consisting of people solely interested technology. The use of radio-controlled unmanned aerial vehicles provides insights into what types of autonomy are needed to create appropriate affective interactions with untrained human groups. The observations from the four weeks of practice and eight performances contribute (1) a taxonomy and methods for creating affect exchanges between robots and untrained human groups, (2) the importance of improvisation within robot theater, (3) insights into how untrained human groups form expectations about robots, and (4) awareness of the importance of safety and reliability as a design constraint for public engagement with robot platforms. The taxonomy captures that apparent affect can be created without explicit affective behaviors by the robot, but requires talented actors to convey the situation or express reactions. The audience’s response to robot crashes was a function of whether they had the opportunity to observe how the actors reacted to robot crashes on stage, suggesting that pre-existing expectations must be taken into account in the design of autonomy. Furthermore, it appears that the public expect robots to be more reliable (an expectation of consumer product hardening) and safe (an expectation from product liability) than the current capabilities and this may be a major challenge or even legal barrier for introducing robots into shared public spaces. These contributions are expected to inform design strategies for increasing public engagement with robot platforms through affect, and shows the value of arts-based approaches to public encounters with robots both for generating design strategies and for evaluation.     

On the security of a visual cryptography scheme for color images

Hou [Visual cryptography for color images, Pattern Recognition 36 (2003) 1619-1629] proposed a four-share visual cryptography scheme for color images. The scheme splits a dithered eight-color secret image into four shares: the black mask and other three shares. It was claimed that without knowing the black mask, no information about the secret image can be obtained even if all the other three shares are known. In this paper, we show that this may be true for a few specific two-color secret images only. In all other cases, however, security cannot be guaranteed. We show that an attacker can compromise a randomly chosen two-color secret image from any two of the other three shares with probability by completely recovering the shape and pattern of the secret image. The advantage will increase to if all the three shares are known. If the secret image has three or four colors, we show that the attacker can compromise it with probability and , respectively. Finally, we show that our technique can be extended to compromising secret images with more than four colors.     

Robust skeletonization using the discrete λ-medial axis

Medial axes and skeletons are notoriously sensitive to contour irregularities. This lack of stability is a serious problem for applications in e.g. shape analysis and recognition. In 2005, Chazal and Lieutier introduced the λ-medial axis as a new concept for computing the medial axis of a shape subject to single parameter filtering. The λ-medial axis is stable under small shape perturbations, as proved by these authors. In this article, a discrete λ-medial axis (DLMA) is introduced and compared with the recently introduced integer medial axis (GIMA). We show that DLMA provides measurably better results than GIMA, with regard to stability and sensibility to rotations. We give efficient algorithms to compute the DLMA, and we also introduce a variant of the DLMA which may be computed in linear-time.     

The minimum information about failures for solving non-local tasks in message-passing systems

We first define the basic notions of local and non-local tasks for distributed systems. Intuitively, a task is local if, in a system with no failures, each process can compute its output value locally by applying some local function on its own input value (so the output value of each process depends only on the process’ own input value, not on the input values of the other processes); a task is nonlocal otherwise. All the interesting distributed tasks, including all those that have been investigated in the literature (e.g., consensus, set agreement, renaming, atomic commit, etc.) are non-local. In this paper we consider non-local tasks and determine the minimum information about failures that is necessary to solve such tasks in message-passing distributed systems. As part of this work, we also introduces weak set agreement—a natural weakening of set agreement—and show that, in some precise sense, it is the weakest nonlocal task in message-passing systems.