Using simulation and multi-criteria methods to provide robust solutions to dispatching problems in a flow shop with multiple processors

Dispatching rules are important to the performance of a manufacturing system. Selective applications of different priority rules at different processing stages in a multiple workstation manufacturing system have a positive impact on shop performance. This type of problem is a combinatorial dispatching decision. However, no dispatching rule can consistently produce better performance than all other rules under a variety of operating conditions and criteria. It is the purpose of this study to provide a robust solution for a dispatching decision that will have ‘good’ performance under different operating scenarios. In this paper a simulation case of a flow shop with multiple processors is proposed, specifically a multi-layer ceramic capacitor manufacturing system. Two multiple criteria decision-making methods – techniques for order preference by similarity to ideal solution (TOPSIS) and an analytic hierarchy process (AHP) – in combination with Taguchi orthogonal array are used to find the most suitable dispatching rule for every workstation. The results show that for 15 production scenarios and 4 criteria this combinatorial dispatching rule is robust, in the sense that it outperforms other commonly employed strategies.     

Electron‐beam deposition of MgO on plastic substrate and manufacturing flexible flat fluorescent lamp

Abstract— A flexible fluorescent lamp that utilizes the same plasma discharge mode as in PDPs has been manufactured. The structure of the flexible lamp is simple and easy to manufacture. All‐plastic materials including plastic substrates, barrier ribs (spacers), and sealants for low‐temperature manufacturing processing have been adopted except for the phosphor and MgO thin film. The MgO thin films were coated on the plastic substrates as a protection layer against the plasma discharge. The adhesion and biaxial texture of MgO thin film deposited on the plastic substrates, poly‐ethyle‐nenaphthalate (PEN) and polycarbonate (PC), at low temperature (100–180°C) has been characterized. The MgO film on PEN shows good adhesion under a repeated bending test. The manufactured flexible lamp consists of two plastic substrates of about 3 in. on the diagonal, barrier rib (spacer), and external ITO electrodes. The Ne‐Xe (5%) gas mixture at 100–200 Torr was used for the discharge gas. A maximum surface luminance of about 100 cd/m² was achieved for a 1 ‐kHz AC pulse.     

EvoOligo: Oligonucleotide Probe Design With Multiobjective Evolutionary Algorithms

Probe design is one of the most important tasks in successful deoxyribonucleic acid microarray experiments. We propose a multiobjective evolutionary optimization method for oligonucleotide probe design based on the multiobjective nature of the probe design problem. The proposed multiobjective evolutionary approach has several distinguished features, compared with previous methods. First, the evolutionary approach can find better probe sets than existing simple filtering methods with fixed threshold values. Second, the multiobjective approach can easily incorporate the user's custom criteria or change the existing criteria. Third, our approach tries to optimize the combination of probes for the given set of genes, in contrast to other tools that independently search each gene for qualifying probes. Lastly, the multiobjective optimization method provides various sets of probe combinations, among which the user can choose, depending on the target application. The proposed method is implemented as a platform called EvoOligo and is available for service on the Web. We test the performance of EvoOligo by designing probe sets for 19 types of Human Papillomavirus and 52 genes in the Arabidopsis Calmodulin multigene family. The design results from EvoOligo are proven to be superior to those from well-known existing probe design tools, such as OligoArray and OligoWiz.     

Pharmacophore and docking-based combined in-silico study of KDR inhibitors

The growth and metastasis of solid tumors is dependent on angiogenesis. The vascular endothelial growth factor (VEGF) and its cell surface receptor in human KDR (kinase domain containing receptor or VEGFR-2) have particular interest because of their importance in angiogenesis. The development of novel inhibitors of VEGFR-2 would be helpful to check the growth of tumors. Quantitative structure activity relationship (QSAR) analyses used to understand the structural factors affecting inhibitory potency of thiazole-substituted pyrazolone derivatives. Several pharmacophore-based models indicated the importance of steric, hydrophobic and hydrogen bond acceptor groups to inhibitory activity. The comparative molecular field analyses (CoMFA) and comparative molecular similarity indices analyses (CoMSIA) based 3D-QSAR models were derived using pharmacophore-based alignment. Both CoMFA (q² = 0.70, r² = 0.97 and ) and CoMSIA (q² = 0.54, r² = 0.82 and ) gave reasonable results. The molecular docking (receptor-guided technique) with a recently reported receptor structure (PDB = 1YWN) were performed. The docked alignment was subsequently used for 3D-QSAR (CoMFA; q² = 0.56, r² = 0.97, , CoMSIA; q² = 0.58 r² = 0.91, ). The overall both studies were indicated, steric, electrostatic and hydrogen bond acceptor effects contribute to the inhibitory activity. CoMFA and CoMSIA models suggested that a positive bulk with hydrophobic effect is desirable around position 4 and 5 and hydrogen bond acceptor groups around pyrazolones ring will be helpful.     

Multibody dynamics analysis of the driveshaft coupling of the ball and tripod types of constant velocity joints

The paper proposes a multibody dynamic simulation to numerically evaluate the generated axial force (GAF) and plunging resistant force (PRF) practically related to the shudder and idling vibration of an automobile. A numerical analysis of the drive shaft coupling of a ball joint (BJ) and two plunging type joints, a tripod joint (TJ), and a very low axial force tripod joint (VTJ), are conducted using the commercial program DAFUL. User-defined subroutines of a friction model illustrating the contacted parts of the outboard and inboard joint are subsequently developed to overcome the numerical instability and improve the solution performance. The Coulomb friction effect is applied to describe the contact models of the lubricated parts in the rolling and sliding mechanisms. The numerical results, in accordance with the joint articulation angle variation, are validated with experimentation. The offset between spider and housing is demonstrated to be the critical role in producing the third order component of the axial force that potentially causes the noise and vibration in the vehicle. The VTJ shows an excellent behavior for the shudder when compared with the TJ. In addition, a flexible nonlinear contact analysis coupled with multibody dynamics is also performed to show the dynamic strength characteristics of the rollers, housing, and spider.     

Use of competition detection in TCP for simple topology networks

The fairness (or TCP-friendliness) of recent high-speed TCP proposals for high bandwidth-delay product networks is generally poor. We believe that the lack of TCP-friendliness of high-speed TCP proposals stems from their ineffectiveness in detecting competing TCP flows. We suggest a competition detection mechanism for a single TCP flow to detect the presence of competing TCP flows. We propose a new TCP, called Adaptive TCP (A-TCP) to demonstrate the usefulness of the competition detection mechanism. A-TCP uses the competition detection mechanism to control its aggressiveness: If it does not detect competing flows, a single A-TCP flow increases its sending rate aggressively in order to highly utilize the network. Otherwise, it behaves like a standard TCP flow to fairly share network resources with competing flows. We implemented A-TCP as part of Linux as well as in ns-2. Experimental results show that A-TCP achieves better fairness than existing high-speed TCP proposals when they compete against standard TCP in simple topology networks.     

Multi-criterion Pareto based particle swarm optimized polynomial neural network for classification: A review and state-of-the-art

In this paper, we proposed a multi-objective Pareto based particle swarm optimization (MOPPSO) to minimize the architectural complexity and maximize the classification accuracy of a polynomial neural network (PNN). To support this, we provide an extensive review of the literature on multi-objective particle swarm optimization and PNN. Classification using PNN can be considered as a multi-objective problem rather than as a single objective one. Measures like classification accuracy and architectural complexity used for evaluating PNN based classification can be thought of as two different conflicting criterions. Using these two metrics as the criteria of classification problem, the proposed MOPPSO technique attempts to find out a set of non-dominated solutions with less complex PNN architecture and high classification accuracy. An extensive experimental study has been carried out to compare the importance and effectiveness of the proposed method with the chosen state-of-the-art multi-objective particle swarm optimization (MOPSO) algorithm using several benchmark datasets. A comprehensive bibliography is included for further enhancement of this area.     

3-D manipulation of millimeter- and micro-sized objects using an acoustically excited oscillating bubble

This communication describes novel 3-D manipulations of objects using an acoustically excited oscillating bubble deposited on a hydrophobic rod tip. The oscillating bubble captures various millimeter- and micron-sized neighboring objects including glass and polystyrene beads (~100 μm), fish egg, and live water flea (~1 mm). The captured objects are carried in a 3-D space by traversing the bubble tip, and released at desired positions by simply turning off the oscillation. Carrying performance is characterized along with high-speed imaging of oscillating bubbles by varying the frequency and amplitude of the acoustic excitation and the carrying speed. The higher the oscillation amplitude, the higher the carrying efficiency. The maximum carrying speed is measured at over 3 mm/s. This method is effective with a low-level acoustic excitation (bubble oscillation amplitude relative to the diameter ≤5%), possibly providing a cost-effective, soft-contact manipulating tool for handling biological objects.     

Preparation and characterization of nanoporous polyimide films from triblock copolyimides

Nanoporous polyimide films were prepared from triblock copolyimides. A thermally labile polymer, poly(propylene glycol), was incorporated into polyimides based on 4,4-(hexafluoroisopropylidene)diphthalic anhydride to obtain triblock copolyimides. Nanofoams were formed by thermolysis of the labile block. The thermal properties of the copolymers were investigated by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The nanopores were characterized by scanning electron microscopy (SEM).     

A -based layout design for gratings allocation

In the design process of gratings, the grating layout design is the most important activity influencing manufacturing cost. In the grating layout design, the key to saving manufacturing cost is to find a design with a minimal number of cutting operations. This paper presents an application of the A^* algorithm in grating layout design. The design problem is represented as the space search problem of design alternatives. A^* explores the feasible alternatives within the space, until an optimal solution is obtained.