预加重与MMSE 结合的语音增强方法

基于语音周期性的特点,提出了一种预加重的MMSE语音增强的改进算法.首先,算法在尽量保留语音信息基础上对带噪语音预加重,使信噪比提高.预加重过程将根据带噪语音信号的周期性的强弱对信号动态加权.处理结果再作为MMSE语音增强的输入并将有利于提高最终的去噪效果.     

基于PLC的碱回收蒸发工段控制系统的设计

根据某造纸厂碱回收蒸发工段的工艺流程和控制要求,从系统硬件组态和软件设计两方面探讨了Simatic S7-300在碱回收蒸发过程中的应用;针对蒸发工段的出效浓黑液浓度难以控制的特点,提出了黑液浓度基于串级控制策略;利用WinCC组态软件实现上位机监控,模拟现场画面,显示所需监控的现场设备.经过运行表明,该系统调节准确,稳定了黑液浓度,降低了能耗,同时节约了设备投资.     

The first original Russian class-III antiarrhythmic nibentan

The paper presents experimental and clinical findings of the new antiarrhythmic drug nibentan. The agent was found to be a class-III antiarrhythmic agent in terms of its electrophysiological effects and an inhibitor of the delayed rectifier potassium current in terms of its effects on the ionic channels of cardiomyocytes. The clinical trial of nibentan shows that the drug is highly effective (in 70-100% of cases) in patients with atrial flutter and fibrillation and in those with supraventricular tachycardia and it is less effective in suppressing ventricular premature contractions and tachycardia. The rate of arrhythmogenic effects produced by the drug was inversely related to its antiarrhythmic action. Nibentan has been approved for clinical use.     

The use of atomic-force microscopy for the analysis of microbiological objects

Atomic force microscopy (AFM) was used for the analysis of rickettsiae and viruses. The specificity of interaction was evaluated on the basis of the adsorption of the analyzed antigen on the polymer-antibody film. The film was formed and transferred onto highly oriented pyrolytic graphite (HOPG) by the method of Langmuir-Schaefer with the use of amphiphilic polymers, alkylated polyethyleneimines. According to the data of AFM, polymer-antibody film was 10-30 nm thick and had ruptures, uneven surface. AFM images of Coxiella burnetii, rotavirus and Venezuelan equine encephalitis virus, immunoadsorbed on the antibody film, were obtained. C.burnetii, due to their size equal to (700-900) x (300-500) x Z = 200 nm, were clearly visible on the underlying surface and could be directly counted. Individual virus particles (60-80 nm) cold not be identified on such surface. To analyze such preparations, the program of image analysis was developed. The program classified the registered image with a certain standard. This program determined the presence of virus antigen on the underlying affinity surface with a high degree of precision.     

Externally and internally controlled attention in infants: an EEG study

This work was designed to investigate EEG indices of Internally and Externally Controlled Attention in infancy. EEG was recorded in 15 infants aged 7-8 months under three experimental conditions: (1) visual attention to a new stimulation (Externally Controlled Attention or baseline condition); (2) attention guided by internal cognitive schemata during 'anticipatory' phase of the peek-a-boo game (Internally Controlled Attention); and (3) 'reappearance' phase of the peek-a-boo game when the experimenter talked and smiled to an infant (reappearance). The relative power (RP) in 4-5 single-Hz theta sub-band increased under both phases of the peek-a-boo game. The reactive changes of 4-5 single-Hz RP at prefrontal and frontal leads under the Internally Controlled Attention condition positively correlated with the total time during which an infant was able to maintain ICA. The RP in 5-6 single-Hz theta sub-band significantly increased only under the Internally Controlled Attention condition and did not correlate with the total time of this type of attention. The results support the concept of 'Diffuse Theta-Response System' that is active during expectancy and effortfully focused attention. In contrast to theta, the RP in 6-7, 7-8, and 8-9 single-Hz bands decreased during both phases of the game. The decrease was maximal at precentral leads and most probably reflected blockage of the sensorimotor (mu) rhythm due to higher motility and muscular tension in the game situation. It is concluded that EEG is an adequate vehicle for investigation of brain mechanisms of attention and voluntary control in infants.     

Short-latency auditory evoked potentials in infants with otitis media

Auditory brain-stem potential findings in 154 healthy infants and infants with different forms of middle-ear pathological conditions (306 ears) were indicative of the inflammatory process influence on the parameters of auditory reception in most cases. The changes in the waves' forms and intraoperative morphological findings in the middle ear were correlated. Objective audiometry allows definite determination of the middle ear trouble which is important in diagnosis of latent otitis in infants who are especially prone to this disease.     

Conjugation of classic Bowman-Birk soy inhibitor with a copolymer of ethylene oxide and propylene oxide

A classical soybean inhibitor of the Bowman-Birk type (BBI) with a copolymer of ethylene oxide and propylene oxide (PE) has been synthesized. The BBI-PE conjugate contain five covalently bound polymeric chains per one protein molecule and retains its capacity to inhibit trypsin (Ki = 10(-10) M), alpha-chymotrypsin (Ki = 7 x 10(-8) M) and human granulocyte elastase (Ki = 3 x 10(-8) M). The preservation of the antiproteinase activity in the antichymotrypsin center creates a prerequisite for the manifestation of the anticarcinogenic effect of the inhibitor.