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21.
MA González-Gay R Blanco V Abraira C García-Porrúa D Ibá?ez MJ García-Pais MT Rigueiro A Sánchez-Andrade J Guerrero E Casariego 《Canadian Metallurgical Quarterly》1997,24(11):2171-2176
OBJECTIVE: To assess the longterm survival of patients with giant cell arteritis (GCA) in a well defined area in Northwestern Spain. METHODS: A followup study of consecutive biopsy proven patients with GCA diagnosed in Lugo, Spain January 1, 1982-March 31, 1996 was performed. Patients were followed from time of diagnosis until either their death or October 1, 1996. Time and cause of death were reviewed. Statistical methods included standardized mortality ratio (SMR), and Kaplan-Meier product-limit survival analysis. Cox proportional hazard models were used to identify clinical features and laboratory findings associated with survival. RESULTS: By October 1, 1996, full information about 109 biopsy proven patients with GCA (59 men/50 women) was available. The mean age +/- SD at the time of diagnosis was 73.9 +/- 7.3 years for women and 74.1 +/- 5.8 for men (p = NS). After a median followup of 54 months, 22 patients (20.2%) had died. Three died within the first month after diagnosis due to either vascular complications related to GCA or therapy complications. Apart from a history of severe underlying diseases (comorbid condition unrelated to GCA), neither sex nor any clinical features of GCA were significantly associated with an increase in mortality. As in the general population of the same age in Lugo, the majority of deaths were due to cardiovascular and cerebrovascular complications. SMR was 0.80 (95% CI 0.47-1.13). One, 2, 5, and 10 year survival rates were 95, 91, 81, and 62%, respectively. Hazard function was 1.8% at Day 30 after diagnosis and remained low until the end of the first year of treatment. Thereafter, mortality increased slightly. As this function was constant, we applied an exponential model. The estimated risk of death with this model was 5.3% per year. CONCLUSION: Longterm mortality of GCA in our area is low. However, it may be possible to further lower the mortality rate through early diagnosis and careful followup. 相似文献
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23.
Raquel Ibáñez Marco Peluso Armelle Munnia Sara Piro Carlos A. González Pilar Amiano M. J. Tormo Eva Ardanaz Aurelio Barricarte Antonio Berenguer M. Dolores Chirlaque Miren Dorronsoro Paula Jakszyn Nerea Larrañaga Carmen Martínez Carmen Navarro J. Ramón Quirós M. José Sánchez Antonio Agudo 《European Food Research and Technology》2009,229(4):549-559
The aim of this study was to assess the relationship between bulky DNA adducts in white blood cells (WBC) and lifestyle factors
in a sample from the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). 296 subjects
aged between 35 and 64 years, from five regions, were included. Food intake was estimated with a computerized version of dietary
history questionnaire. Daily intake of polycyclic aromatic hydrocarbons (PAH) was estimated using a database with information
on food content of potential carcinogens. Data on lifestyle and health factors were collected and DNA adducts measured using
the nuclease P1 32P-postlabelling technique. Geometric means of adducts were similar for men and women (4.11/109 and 3.94/109 nucleotides, respectively). Highest levels of adduct were observed in non-smokers and non-occupationally exposed. Meat intake,
oils and fats were associated with higher levels of adducts, but all non-statistically significant. Higher intakes of calcium,
sodium and phosphorus were associated with lower adducts levels. Summarising, our study shows that bulky adducts measured
by 32P-postlabelling in DNA from WBC do not correlate with the usual diet of healthy Spanish adults. Although it has been proposed
that diet be the main source of PAH in nonsmokers without occupational exposure, DNA adducts do not seem to be suitable biomarkers
of dietary PAH in general population. 相似文献
24.
V Martínez Ibá?ez J Lloret J Broto C Margarit R Charco M Ezzedine J Boix-Ochoa 《Canadian Metallurgical Quarterly》1993,6(3):120-122
The lack of availability of pediatric donors for liver transplant has resulted in a high mortality rate among children awaiting transplantation, especially in patients weighing less than 10 kg. Knowledge of techniques of liver reduction allows liver transplantation in low-weight children with an adult liver graft, although with increased risk. The authors studied 70 pediatric liver transplants, 14.3% of whom received a reduced-size organ. Maximal difference between donor and recipient weight was 7.7. Segments II, III and IV (right hepatectomy) were transplanted in eight cases while segments II and III were transplanted in two cases. Transfusional requirements during the 48 hour postoperative period were not significantly different between patients with reduced-size liver and patients who received the full-size organ. There was not morbi-mortality secondary to surgical technique in reduced liver transplant group of patients. 相似文献
25.
A comparison of methods for linear prediction of apple flavour from gas chromatographic measurements
A comparative study of linear methods for prediction of sensory profiles from gas chromatography (GC) measurements was performed. The data used came from an experiment on the effect of storing apples at various oxygen concentrations. Partial least-squares regression and continuum regression showed the best performance, measured by a two-step cross-validation principle. The traditional prediction error sum of squares (PRESS) overestimated the predictive ability of a multiple linear regression approach. The quality of the predictions of sensory properties from GC analyses was measured in terms of a ‘panel size equivalent’. Thus, the predictions obtained in the present study were as accurate as predictions from an assessor panel consisting of 4–9 assessors, depending on the sensory property in question. 相似文献
26.
Genetic strain variations in the metaphase-II phenotype of mouse oocytes matured in vivo or in vitro
Ibáñez E Sanfins A Combelles CM Overström EW Albertini DF 《Reproduction (Cambridge, England)》2005,130(6):845-855
The interplay between genetic and epigenetic factors plays a central role in mammalian embryo production strategies that superimpose ex vivo or in vivo manipulations upon strain background characteristics. In this study, we examined the relationship between genetic background and the phenotypic properties of mouse metaphase-II (M-II) oocytes that were matured under in vivo (IVO) or in vitro conditions, either in a basal (IVM) or a supplemented (IVM + ) medium. Differences existed amongst inbred (C57BL/6), outbred (CF-1, Black Swiss, NU/NU) and hybrid lines (B6D2F1) induced to superovulate with regard to cytoplasmic microtubule organizing center (MTOC) number but not spindle size or shape, except for larger and asymmetrical spindles in Black Swiss oocytes. When oocytes were matured in culture, meiotic spindle and cytoplasmic phenotypic properties of M-II oocytes were affected relative to in vivo conditions and between strains. Specifically, measures of meiotic spindle size, shape, polar pericentrin distribution and cytoplasmic MTOC number all revealed characteristic variations. Interestingly, the overall reduction in cytoplasmic MTOC number noted upon IVM was concomitant with an overall increase in spindle and polar body size. Maturation under IVM + conditions resulted in a further decrease in cytoplasmic MTOC number, but spindle and polar body characteristics were intermediate between IVO and IVM. How these oocyte phenotypic properties of maternal origin may be linked to predictive assessments of fecundity remains to be established. 相似文献
27.
Quasi-spherical focal spot in two-photon scanning microscopy by three-ring apodization 总被引:1,自引:0,他引:1
Ibáñez-López C Saavedra G Plamann K Boyer G Martínez-Corral M 《Microscopy research and technique》2005,67(1):22-26
We present a beam-shaping technique for two-photon excitation (TPE) fluorescence microscopy. We show that by inserting a properly designed three-ring pupil filter in the illumination beam of the microscope, the effective optical sectioning capacity of such a system improves so that the point spread function gets a quasi-spherical shape. Such an improvement, which allows the acquisition of 3D images with isotropic quality, is obtained at the expense of only a small increase of the overall energy in the axial sidelobes. The performance of this technique is illustrated with a scanning TPE microscopy experiment in which the image of small beads is obtained. We demonstrate an effective narrowing of 12.5% in the axial extent of the point spread function, while keeping the 82% of the spot-fluorescence efficiency. 相似文献
28.
A Bayesian approach to the effect of selection for growth rate on sensory meat quality of rabbit 总被引:1,自引:0,他引:1
Hernández P Guerrero L Ramírez J Mekkawy W Pla M Ariño B Ibáñez N Blasco A 《Meat science》2005,69(1):123-127
The effect of selection for growth rate on the sensory characteristics of rabbit meat was assessed by comparing a selected and a control population of rabbits. Embryos belonging to generation 7th were frozen, thawed and implanted in does in order to produce the control group. The control group was formed from the offspring of the embryos belonging to the 7th generation. Selected animals belonging to 21st generation (S) were compared with animals of the control group (C), both were contemporary. Forty animals per group were slaughtered at 9-weeks-old. The sensory analysis was carried out on samples of the Longissimus dorsi muscle. The parameters evaluated were: intensity of rabbit flavour (IRF), aniseed odour (AO), aniseed flavour (AF), liver flavour (LF), tenderness (T), juiciness (J), fibrousness (F). A Bayesian analysis was performed. The ratio of the selection and control effects was analysed. There was a difference between the selected and control groups for IRF, AO, AF and LF. Conversely, no differences were found in T, J and F between groups. Selected group had 3% and 23% higher values of IRF and LF, respectively, than the control group. A relevant effect of selection on AO and AF appeared (probability of relevance P(r)=1), with lower values for selected animals. There was a difference between male and female groups for IRF, but this was not relevant. No differences between sexes were found for the rest of the characteristics evaluated. Selection for growth rate did not affect the main sensory characteristics of meat, like T and J but, it had a negative effect on some flavour characteristics. 相似文献
29.
Andreas Holzmeister Andreas Greiner Joachim H. Wendorff 《Polymer Engineering and Science》2009,49(1):148-153
Electrospinning is a highly versatile technique that allows producing fibers with diameters down to a few nanometers not only from polymers but also from metals, metal oxides, or ceramics. Fiber formation in electrospinning differs strongly from other fiber producing methods such as extrusion in that it is basically governed by self‐assembly processes induced by specific electrostatic interactions following the Earnshaw theorem of electrostatics. This allows the production of nanofibers with very peculiar shapes. Here, we report the one step fabrication of barbed nanofibers due to a particular choice of the spinning conditions. Such barbed fibers allow, among others, to control the total porosity of nanofiber nonwovens and to reduce the tendency of linear nano‐objects towards aggregation. POLYM. ENG. SCI., 2009. © 2008 Society of Plastics Engineers 相似文献
30.
Mendiola JA Santoyo S Cifuentes A Reglero G Ibáñez E Señoráns FJ 《Journal of food protection》2008,71(10):2138-2143
The objective of this research was to evaluate the antimicrobial activity of carbon dioxide extracts of the unicellular biflagellated green alga Dunaliella salina against Escherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus niger. The effects of different extraction pressures ranging from 185 to 442 bar and extraction temperatures ranging from 9.8 to 45.2 degrees C on the extracts' composition and consequently on their antimicrobial activities were investigated. The extracts were analyzed by gas chromatography-mass spectrometry in order to identify the compounds responsible for the antimicrobial activity detected. Fourteen different volatile compounds and several fatty acids were identified. The highest antimicrobial activity was obtained using 314 bar and 9.8 degrees C. Under these conditions, the presence of an indolic derivative that had never been reported in D. salina was detected in the extract, together with polyunsaturated fatty acids and compounds related to carotene metabolism, such as beta-ionone and neophytadiene, with known antimicrobial activity. 相似文献