Successful management for chemorefractory testicular cancer with brain and lung metastases. A case report

This is a report of successful management for a far advanced, chemorefractory testicular cancer patient. A 29-year-old male was referred to our hospital for the treatment of progressive lung metastases with elevated hCG level, which had recurred after complete remission following 3 courses of BEP chemotherapy and progressed after transient partial regression following 2 courses of intensified EP chemotherapy. In addition, a 3 cm in diameter, solitary brain metastasis was detected on CT. First, we performed wedge resection of bilateral pulmonary lower lobe for chemorefractory pulmonary metastases. Histological examination revealed viable embryonal carcinoma identical to the primary one. Thereafter, whole brain irradiation in combination with VIP chemotherapy (etoposide 100 mg/m2, cisplatin 20 mg/m2 and ifosfamide 1200 mg/m2 daily for 5 consecutive days) was carried out to treat brain metastasis. By 2 cycles of VIP therapy and irradiation (36 Gy), partial tumor regression and normalization of hCG level were achieved, leading to salvage surgery of the brain metastasis which histologically proved to be necrosis. Following an additional cycle of VIP therapy, the patient has been free of recurrence 24 months after completion of the treatment.     

Doping Effects in Rare-Earth Borides

Boron-rich cluster compounds are studied for their potential as high-temperature thermoelectric materials with low thermal conductivity. Two B₁₂ icosahedra systems with attractive thermoelectric properties have recently been discovered: p-type REB₄₄Si₂ (where RE stands for rare earth) and the anomalous n-type series of RE-B-C(N) homologous compounds. Three different doping effects of these compounds were investigated in this work in an attempt to control the properties: doping disorder into REB₄₄Si₂, which is a variable-range hopping system, V-doping of YB₄₄Si₂, and C-doping (carbon composition control) of YB_28.5C₄. The attempt to enhance the Seebeck coefficient in TbB₄₄Si₂ through disorder was inconclusive, while V-doping of YB₄₄Si₂ had a negative effect on the thermoelectric properties. Controlling the carbon composition of YB_28.5C₄ appeared to be a promising route for increasing the absolute value of the Seebeck coefficient.     

Calculation of sudden three‐phase short‐circuit current of turbine generators by 3D magnetic field analysis

Sudden three‐phase short‐circuit current of a turbine generator was calculated by a three‐dimensional magnetic field analysis. That analysis takes into account the rotation, magnetic saturation, and eddy current at a rotor part. To compare test results and calculated results, a method was proposed for short‐circuit phase estimation at sudden three‐phase short‐circuit test by line voltage waveform of the test results. The calculated results of short‐circuit current waveform are in good agreement with the test results. © 2005 Wiley Periodicals, Inc. Electr Eng Jpn, 153(1): 54–62, 2005; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20110     

Robust parallel compensator design for output feedback stabilization of plants with structured uncertainty

This paper deals with a design problem of robust parallel compensator which guarantees the existence of a constant gain output feedback controller for plants with structured uncertainty. First, robust design conditions of such a compensator are derived by using Kharitonov’s Theorem. Then, based on conditions provided, the parallel compensator is designed by utilizing the maximal range of interval perturbations of the plant. A numerical example is given to demonstrate the validity of the results.     

Functional myocardial perfusion abnormality induced by left ventricular asynchronous contraction: experimental study using myocardial contrast echocardiography

OBJECTIVES: The aim of this study was to clarify how myocardial perfusion is impaired by asynchronous contraction. BACKGROUND: False septal hypoperfusion is noted in some patients with left bundle branch block. METHODS: Eight dogs were examined with epicardial pacing at the left ventricular posterior wall, the right ventricular anterior wall and, as a control, the right atrial appendage. The pacing rate was 80, 110 and 150 beats/min (bpm). Myocardial perfusion was assessed by contrast echocardiography. RESULTS: Left ventricular pacing at 80 and 110 bpm did not change systolic wall thickening or contrast intensity at the pacing site, although an early excitation notch was noted at the pacing site. However, at 150 bpm, systolic thickening was impaired (23.3 +/- 4.2% vs. 37.0 +/- 2.6% during atrial pacing, p < 0.05), and the peak intensity ratio of the pacing site to the ventricular septum was significantly decreased (24.1 +/- 5.7% vs. 37.0 +/- 2.8% at a pacing rate of 80 bpm, p < 0.01). The peak intensity ratio correlated with systolic wall thickening at the pacing site (y = 0.413 x -0.028, r = 0.81, p < 0.0001). However, right ventricular pacing did not change either systolic thickening or the peak intensity ratio at any pacing rate, although an early excitation notch was noted on the ventricular septum. CONCLUSIONS: Wall motion abnormalities after early excitation vary depending on the pacing mode. When tachycardia induces regional wall motion abnormalities, the ventricular wall of the pacing site is functionally hypoperfused.     

Facilitation of passive avoidance response by newly synthesized cationized arginine vasopressin fragment 4-9 in rats

The effects of a newly synthesized cationized arginine vasopressin fragment 4-9 analogue (C-AVP-(4-9)) on learning and memory in rats were studied by the passive avoidance test. C-AVP-(4-9) and its parent peptide, arginine vasopressin fragment 4-9 (AVP-(4-9)), a well known potent neuropeptide, were subcutaneously injected 1.5 hr prior to the retention test. The most effective doses of C-AVP-(4-9) and AVP-(4-9) were 8.6 x 10(-2) and 1.3 nmol/kg, respectively. To evaluate the distribution of C-AVP-(4-9) in the control nervous system (CNS), apparent tissue-plasma concentration rations (Kp.app) of intravenously administered radioiodinated C-AVP-(4-9) (125I-C-AVP-(4-9)) in the CNS in mice were determined. At the apparent steady state of plasma concentration of 125I-C-AVP-(4-9), the Kp.app values of the 125I-C-AVP-(4-9) in the cerebrum, cerebellum and spinal cord were over 12 times higher than that of the vascular space marker which slightly penetrates the BBB. Moreover, the rat cerebral homogenate converted C-AVP-(4-9) into its parent peptide AVP-(4-9). These results suggest that the potent effects of C-AVP-(4-9) on learning and memory may be due to AVP-(4-9) generated as a result of distribution and metabolism of peripherally administered C-AVP-(4-9) in the CNS.     

Simultaneous analysis of optical and mechanical properties of cross-linked azobenzene-containing liquid-crystalline polymer films

The photomechanical behavior of cross-linked azobenzene-containing liquid-crystalline polymer films was investigated by means of simultaneous measurement of their optical and mechanical properties. The connection between photoisomerization of the azobenzene moieties, photoinduced change in molecular alignment, photoinduced stress generation, and macroscopic bending was analyzed. Upon UV irradiation, the films exhibited bending due to gradient in cis-azobenzene content, and subsequent unbending when cis-azobenzene content became uniform throughout the film. The maximum photoinduced stress was generated in the same time scale as the time required to reach photostationary state in the cis-azobenzene concentration. The maximum values of photogenerated stress strongly depended on the crosslinker concentration, even if the azobenzene concentration and the cis-azobenzene content in the photostationary state were similar for all the polymer films. The stress is connected to the initial Young's modulus and also to the photoinduced change in birefringence of the polymer films. In addition, a significant photoinduced decrease in Young's modulus was for the first time observed in cross-linked azobenzene-containing liquid-crystalline polymers, which is likely to be an important factor in dictating their photomechanical behavior.     

Melt growth of multicrystalline SiGe with large compositional distribution for new solar cell applications

The melt-growth conditions to obtain SiGe multicrystals with microscopic compositional distribution are presented. These SiGe multicrystals are useful for new solar cells whose wavelength dependence of the absorption coefficient can be freely designed. The multicrystals with wide compositional distribution from Si to Ge can be grown by a melt growth technique such as the practical casting method. In this work, it was studied as to how much the micro- and macroscopic compositional distribution in SiGe multicrystals grown from binary Si–Ge melts could be controlled by the melt composition and the cooling process. Such SiGe multicrystals with wide distribution of the composition would also have wide distribution of the absorption coefficient, and could be hopeful for new solar cell applications using the practical casting method.     

PFC Design via FRIT Approach for Adaptive Output Feedback Control of Discrete‐Time Systems

This paper deals with a design problem of an adaptive output feedback control for discrete‐time systems with a parallel feedforward compensator (PFC), which is designed for making the augmented controlled system “Almost Strictly Positive Real” (ASPR). A PFC design scheme by a fictitious reference iterative tuning (FRIT) approach with only using an input/output experimental data set will be proposed for discrete‐time systems in order to design an adaptive output feedback control system. Furthermore, the effectiveness of the proposed PFC design method will be confirmed through numerical simulations by designing an adaptive control system with adaptive NN (neural network) for an uncertain discrete‐time system. © 2014 Wiley Periodicals, Inc. Electr Eng Jpn, 187(1): 24–32, 2014; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/eej.22456