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排序方式: 共有618条查询结果,搜索用时 31 毫秒
131.
Francesco Todescato Ilaria Fortunati Samuele Gardin Eleonora Garbin Elisabetta Collini Renato Bozio Jacek J. Jasieniak Gioia Della Giustina Giovanna Brusatin Stefano Toffanin Raffaella Signorini 《Advanced functional materials》2012,22(2):337-344
The development of a solution‐deposited up‐converted distributed feedback laser prototype is presented. It employs a sol–gel silica/germania soft‐lithographed microcavity and CdSe–CdZnS–ZnS quantum dot/sol–gel zirconia composites as optical gain material. Characterization of the linear and nonlinear optical properties of quantum dots establishes their high absorption cross‐sections in the one‐ and two‐ photon absorption regimes to be 1 × 10?14 cm2 and 5 × 104 GM, respectively. In addition, ultrafast transient absorption dynamics measurements of the graded seal quantum dots reveal that the Auger recombination lifetime is 220 ps, a value two times higher than that of the corresponding CdSe core. These factors enable the use of such quantum dots as optically pumped gain media, operating in the one‐ and two‐photon absorption regime. The incorporation of CdSe–CdZnS–ZnS quantum dots within a zirconia host matrix affords a quantum‐dot ink that can be directly deposited on our soft‐lithographed distributed feedback grating to form an all‐solution‐processed microcavity laser. 相似文献
132.
Camille Jacques Ilaria Floris Batrice Lejeune 《International journal of molecular sciences》2021,22(13)
Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are two cytokines involved in the perpetuation of the chronic inflammation state characterizing rheumatoid arthritis (RA). Significant advances in the treatment of this pathology have been made over the past ten years, partially through the development of anti-TNF and anti-IL-1 therapies. However, major side effects still persist and new alternative therapies should be considered. The formulation of the micro-immunotherapy medicine (MIM) 2LARTH® uses ultra-low doses (ULD) of TNF-α, IL-1β, and IL-2, in association with other immune factors, to gently restore the body’s homeostasis. The first part of this review aims at delineating the pivotal roles played by IL-1β and TNF-α in RA physiopathology, leading to the development of anti-TNF and anti-IL-1 therapeutic agents. In a second part, an emphasis will be made on explaining the rationale of using multiple therapeutic targets, including both IL-1β and TNF-α in 2LARTH® medicine. Particular attention will be paid to the ULD of those two main pro-inflammatory factors in order to counteract their overexpression through the lens of their molecular implication in RA pathogenesis. 相似文献
133.
Manar Aoun Ilaria Passerini Pietro Chiurazzi Marianthi Karali Irene De Rienzo Giovanna Sartor Vittoria Murro Natalia Filimonova Marco Seri Sandro Banfi 《International journal of molecular sciences》2021,22(13)
Inherited retinal diseases (IRDs) are a heterogeneous group of conditions that include retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA) and early-onset severe retinal dystrophy (EO[S]RD), which differ in severity and age of onset. IRDs are caused by mutations in >250 genes. Variants in the RPE65 gene account for 0.6–6% of RP and 3–16% of LCA/EORD cases. Voretigene neparvovec is a gene therapy approved for the treatment of patients with an autosomal recessive retinal dystrophy due to confirmed biallelic RPE65 variants (RPE65-IRDs). Therefore, the accurate molecular diagnosis of RPE65-IRDs is crucial to identify ‘actionable’ genotypes—i.e., genotypes that may benefit from the treatment—and is an integral part of patient management. To date, hundreds of RPE65 variants have been identified, some of which are classified as pathogenic or likely pathogenic, while the significance of others is yet to be established. In this review, we provide an overview of the genetic diagnostic workup needed to select patients that could be eligible for voretigene neparvovec treatment. Careful clinical characterization of patients by multidisciplinary teams of experts, combined with the availability of next-generation sequencing approaches, can accelerate patients’ access to available therapeutic options. 相似文献
134.
Andrea Z. Dalla Valle Ilaria Mignani Anna Spinardi Fabio Galvano Salvatore Ciappellano 《European Food Research and Technology》2007,225(2):167-172
Total polyphenols, carotenoids and vitamin C were assessed in three different peaches cultivars (Prunus persica): ‘Luisa Berselli’ (LB), ‘Stark Earlyglo’ (SE) and ‘Maria Serena’ (MS). Total antioxidant capacity of fruits and plasma antioxidant
activity after ingestion of fruits were determined as Trolox equivalent antioxidant capacity (TEAC) and as plasma total radical-trapping
potential (TRAP) respectively. The amount of polyphenols, carotenoids and vitamin C resulted to be generally similar in the
three cultivars. TEAC, measured from harvest to 7 days postharvest, resulted to be influenced mainly by vitamin C content,
whereas polyphenols and carotenoids seemed to play a secondary role. Although TEAC was similar in the three cultivars, only
LB significantly increased the TRAP in human plasma at 1, 2 and 4 h after ingestion of peaches. Sugar moiety, condensed and
glycoside phenols are suggested to be involved in the higher effect on plasma TRAP of LB. 相似文献
135.
Fratoddi I Venditti I Battocchio C Polzonetti G Cametti C Russo MV 《Nanoscale research letters》2011,6(1):98
Noble metal nanoparticles of different sizes and shapes combined with conjugated functional polymers give rise to advanced
core shell hybrids with interesting physical characteristics and potential applications in sensors or cancer therapy. In this
paper, a versatile and facile synthesis of core shell systems based on noble metal nanoparticles (AuNPs, AgNPs, PtNPs), coated
by copolymers belonging to the class of substituted polyacetylenes has been developed. The polymeric shells containing functionalities
such as phenyl, ammonium, or thiol pending groups have been chosen in order to tune hydrophilic and hydrophobic properties
and solubility of the target core shell hybrids. The Au, Ag, or Pt nanoparticles coated by poly(dimethylpropargylamonium chloride),
or poly(phenylacetylene-co-allylmercaptan). The chemical structure of polymeric shell, size and size distribution and optical
properties of hybrids have been assessed. The mean diameter of the metal core has been measured (about 10-30 nm) with polymeric
shell of about 2 nm. 相似文献
136.
137.
Mariotti Ilaria Barzotto Mariachiara Cor Giancarlo Saloriani Stefano 《The Annals of Regional Science》2020,64(3):523-546
The Annals of Regional Science - The present paper aims at exploring the location behaviour of manufacturing firms, according to their ownership: domestic firms (henceforth DOMs) and inward foreign... 相似文献
138.
Dr. Cristina Tintori Ilaria Laurenzana Francesco La Rocca Dr. Federico Falchi Prof. Fabio Carraro Alba Ruiz Prof. José A. Esté Miroslava Kissova Dr. Emmanuele Crespan Prof. Giovanni Maga Prof. Mariangela Biava Dr. Chiara Brullo Prof. Silvia Schenone Prof. Maurizio Botta 《ChemMedChem》2013,8(8):1353-1360
Hematopoietic cell kinase (Hck) is a member of the Src family of non‐receptor protein tyrosine kinases. High levels of Hck are associated with drug resistance in chronic myeloid leukemia. Furthermore, Hck activity has been connected with HIV‐1. Herein, structure‐based drug design efforts were aimed at identifying novel Hck inhibitors. First, an in‐house library of pyrazolo[3,4‐d]pyrimidine derivatives, which were previously shown to be dual Abl and c‐Src inhibitors, was analyzed by docking studies within the ATP binding site of Hck to select the best candidates to be tested in a cell‐free assay. Next, the same computational protocol was applied to screen a database of commercially available compounds. As a result, most of the selected compounds were found active against Hck, with Ki values ranging from 0.14 to 18.4 μM , confirming the suitability of the computational approach adopted. Furthermore, selected compounds showed an interesting antiproliferative activity profile against the human leukemia cell line KU‐812, and one compound was found to block HIV‐1 replication at sub‐toxic concentrations. 相似文献
139.
Ilaria Saltarella Concetta Altamura Aurelia Lamanuzzi Benedetta Apollonio Angelo Vacca Maria Antonia Frassanito Jean-Franois Desaphy 《International journal of molecular sciences》2022,23(13)
Ion channels are pore-forming proteins that allow ions to flow across plasma membranes and intracellular organelles in both excitable and non-excitable cells. They are involved in the regulation of several biological processes (i.e., proliferation, cell volume and shape, differentiation, migration, and apoptosis). Recently, the aberrant expression of ion channels has emerged as an important step of malignant transformation, tumor progression, and drug resistance, leading to the idea of “onco-channelopathy”. Here, we review the contribution of ion channels and transporters in multiple myeloma (MM), a hematological neoplasia characterized by the expansion of tumor plasma cells (MM cells) in the bone marrow (BM). Deregulation of ion channels sustains MM progression by modulating intracellular pathways that promote MM cells’ survival, proliferation, and drug resistance. Finally, we focus on the promising role of ion channels as therapeutic targets for the treatment of MM patients in a combination strategy with currently used anti-MM drugs to improve their cytotoxic activity and reduce adverse effects. 相似文献
140.
DNA barcoding as a new tool for food traceability 总被引:1,自引:0,他引:1
Andrea Galimberti Fabrizio De Mattia Alessia Losa Ilaria Bruni Silvia Federici Maurizio Casiraghi Stefano Martellos Massimo Labra 《Food research international (Ottawa, Ont.)》2013,50(1):55-63
Food safety and quality are nowadays a major concern. Any case of food alteration, especially when reported by the media, has a great impact on public opinion. There is an increasing demand for the improvement of quality controls, hence addressing scientific research towards the development of reliable molecular tools for food analysis. DNA barcoding is a widely used molecular-based system, which can identify biological specimens, and is used for the identification of both raw materials and processed food. In this review the results of several researches are critically analyzed, in order to exploit the effectiveness of DNA barcoding in food traceability, and to delineate some best practices in the application of DNA barcoding throughout the industrial pipeline. The use of DNA barcoding for food safety and in the identification of commercial fraud is also discussed. 相似文献