A hybrid dynamic motion prediction method for multibody digital human models based on a motion database and motion knowledge

In this paper, we present a novel method to predict human motion, seeking to combine the advantages of both data-based and knowledge-based motion prediction methods. Our method relies on a database of captured motions for reference and introduces knowledge in the prediction in the form of a motion control law, which is followed while resembling the actually performed reference motion. The prediction is carried out by solving an optimization problem in which the following conditions are imposed to the motion: must fulfill the goals of the task; resemble the reference motion selected from the database; follow a knowledge-based dynamic motion control law; and ensure the dynamic equilibrium of the human model, considering its interactions with the environment. In this work, we apply the proposed method to a database of clutch pedal depression motions, and we present the results for three predictions. The method is validated by comparing the results of the prediction to motions actually performed in similar conditions. The predicted motions closely resemble the motions in the validation database and no significant differences have been noted either in the motion’s kinematics or in the motion’s dynamics.     

Recommending multimedia visiting paths in cultural heritage applications

The valorization and promotion of worldwide Cultural Heritage by the adoption of Information and Communication Technologies represent nowadays some of the most important research issues with a large variety of potential applications. This challenge is particularly perceived in the Italian scenario, where the artistic patrimony is one of the most diverse and rich of the world, able to attract millions of visitors every year to monuments, archaeological sites and museums. In this paper, we present a general recommendation framework able to uniformly manage heterogeneous multimedia data coming from several web repositories and to provide context-aware recommendation techniques supporting intelligent multimedia services for the users—i.e. dynamic visiting paths for a given environment. Specific applications of our system within the cultural heritage domain are proposed by means of real case studies in the mobile environment related both to an outdoor and indoor scenario, together with some results on user’s satisfaction and system accuracy.     

Optimized H.264 Video Encoding and Packetization for Video Transmission Over Pipeline Forwarding Networks

Previous works showed that the quality-of-service (QoS) requirements of multimedia applications can be optimally satisfied by pipeline forwarding (PF) by providing end-to-end delay guarantees as well as high network resource utilization. However, the unavoidable mismatch between reserved resources and the unpredictable traffic profile of a video stream has an impact on the resulting application layer quality. Therefore, a new low-complexity H.264 video encoding and packetization scheme based on a distortion-optimized macroblock grouping technique is designed here to maximize the performance of video transmission on PF networks. The scheme considers the perceptual importance of the different parts of the video data to group the most important information in few packets that are the natural candidates to receive the deterministic service provided by PF. Results show peak signal-to-noise ratio (PSNR) gains up to 2.5 dB over traditional video encoding and packetization schemes, as well as more graceful degradation in case of high network load.     

Sorafenib delivery nanoplatform based on superparamagnetic iron oxide nanoparticles magnetically targets hepatocellular carcinoma

Currently,sorafenib is the only systemic therapy capable of increasing overall survival of hepatocellular carcinoma patients.Unfortunately,its side effects,particularly its overall toxicity,limit the therapeutic response that can be achieved.Superparamagnetic iron oxide nanoparticles (SPIONs) are very attractive for drug delivery because they can be targeted to specific sites in the body through application of a magnetic field,thus improving intratumoral accumulation and reducing adverse effects.Here,nanoformulations based on polyethylene glycol modified phospholipid micelles,loaded with both SPIONs and sorafenib,were successfully prepared and thoroughly investigated by complementary techniques.This nanovector system provided effective drug delivery,had an average hydrodynamic diameter of about 125 nm,had good stability in aqueous medium,and allowed controlled drug loading.Magnetic analysis allowed accurate determination of the amount of SPIONs embedded in each micelle.An in vitro system was designed to test whether the SPION micelles can be efficiently held using a magnetic field under typical flow conditions found in the human liver.Human hepatocellular carcinoma (HepG2) cells were selected as an in vitro system to evaluate tumor cell targeting efficacy of the superparamagnetic micelles loaded with sorafenib.These experiments demonstrated that this delivery platform is able to enhance sorafenib's antitumor effectiveness by magnetic targeting.The magnetic nanovectors described here represent promising candidates for targeting specific hepatic tumor sites,where selective release of sorafenib can improve its efficacy and safety profile.     

Preface: Volume 16, Issue 2

This volume contains the Proceedings of the fifth EXPRESS workshop. The workshop was held in Nice, France, on 7 September 1998, as a satellite event to CONCUR '98.The EXPRESS workshops aim at bringing together researchers interested in the relations between various formal systems, particularly in the field of Concurrency. More specifically, they focus on the comparison between programming concepts (such as concurrent, functional, imperative, logic and object-oriented programming) and between mathematical models of computation (such as process algebras, Petri nets, event structures, modal logics, rewrite systems etc.) on the basis of their relative expressive power.These workshops were originally held as meetings of the HCM project EXPRESS, which has been active with the same focus from January 1994 till December 1997. The first three workshops were held respectively in Amsterdam (1994, chaired by Frits Vaandrager), Tarquinia (1995, chaired by Rocco de Nicola), and Dagstuhl (1996, chaired by Ursula Goltz, Frits Vaandrager and Rocco de Nicola). The fourth workshop, which took place in Santa Margherita Ligure in 1997 and was co-chaired by Catuscia Palamidessi and Joachim Parrow, was organized as a conference with a call for papers and a significant attendance from outside the project. The fifth workshop, EXPRESS '98, was again organised as a (one day) conference, and was also meant as an occasion to discuss on the inheritance of the Express project and possible directions of future research. We had 17 submissions, out of which we selected 7 for inclusion in these proceedings (41%). Additionally, this collection contains the contribution of the two invited speakers, Matthew Hennessy (University of Sussex, UK) and P.S. Thiagarajan (SPIC Mathematical Institute, IN).We would like to thank the authors of the submitted papers, the invited speakers, and the members of the program committee for their contribution to both the meeting and this volume. We also would like to thank INRIA for their help with the local organization, and Michael Mislove for his help with the editing of the proceedings.

EXPRESS '98 Programme Committee
Ilaria Castellani (co-chair, INRIA)	Catuscia Palamidessi (co-chair, PSU)
Luca Aceto (Aalborg Univ.)	Roberto Amadio (Univ. Marseille)
Eike Best (Oldenburg Univ.)	Steve Brookes (CMU)
Philippe Darondeau (INRIA)	Rocco De Nicola (Univ. Firenze)
Jan Willem Klop (CWI)	Patrick Lincoln (SRI)
Frits Vaandrager (Nijmegen Univ.)	Glynn Winskel (Aarhus Univ.)

Full-size table

17 October 1998, Ilaria Castellani and Catuscia Palamidessi     

Knowledge Management in Locating the Patient in an Emergency Medical Service in Italy

This study examines an Emergency Medical Service in order to analyze the composite set of activities and instruments directed at locating the patient. The good management of information about the location of the emergency is highly relevant for a reliable rescue service, but this information depends on knowledge of the territory that is socially distributed between EMS operators and callers. Accordingly, the decision-making process often has to go beyond the emergency service protocols, engaging the operator in undertaking an open negotiation in order to transform the caller’s role from layman to “co-worker”. The patient’s location turns out to be an emerging phenomenon, collaborative work based on knowledge management involving two communities—the callers and the EMS operators—that overlap partially. Drawing examples from emergency calls, the study analyzes the practice of locating a patient as a complex and multi-layered process, highlighting the role played by new and old technologies (the information system and the paper maps) in this activity. We argue that CSCW technologies enable the blended use of different kinds of instruments and support an original interconnection between the professional localization systems and the public’s way of defining a position.     

Self-adaptation and secure information flow in multiparty communications

We present a comprehensive model of structured communications in which self-adaptation and security concerns are jointly addressed. More specifically, we propose a model of multiparty, self-adaptive communications with access control and secure information flow guarantees. In our model, multiparty protocols (choreographies) are described as global types; security violations occur when process implementations of protocol participants attempt to read or write messages of inappropriate security levels within directed exchanges. Such violations trigger adaptation mechanisms that prevent the violations to occur and/or to propagate their effect in the choreography. Our model is equipped with local and global adaptation mechanisms for reacting to security violations of different gravity; type soundness results ensure that the overall multiparty protocol is still correctly executed while the system adapts itself to preserve the participants’ security.     

Light on! Real world evaluation of a P300-based brain-computer interface (BCI) for environment control in a smart home

Brain-computer interface (BCI) systems aim to enable interaction with other people and the environment without muscular activation by the exploitation of changes in brain signals due to the execution of cognitive tasks. In this context, the visual P300 potential appears suited to control smart homes through BCI spellers. The aim of this work is to evaluate whether the widely used character-speller is more sustainable than an icon-based one, designed to operate smart home environment or to communicate moods and needs. Nine subjects with neurodegenerative diseases and no BCI experience used both speller types in a real smart home environment. User experience during BCI tasks was evaluated recording concurrent physiological signals. Usability was assessed for each speller type immediately after use. Classification accuracy was lower for the icon-speller, which was also more attention demanding. However, in subjective evaluations, the effect of a real feedback partially counterbalanced the difficulty in BCI use. PRACTITIONER SUMMARY: Since inclusive BCIs require to consider interface sustainability, we evaluated different ergonomic aspects of the interaction of disabled users with a character-speller (goal: word spelling) and an icon-speller (goal: operating a real smart home). We found the first one as more sustainable in terms of accuracy and cognitive effort.     

Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders

Hyaluronic acid (HA) is a Glycosaminoglycan made of disaccharide units containing N-acetyl-D-glucosamine and glucuronic acid. Its molecular mass can reach 10 MDa and its physiological properties depend on its polymeric property, polyelectrolyte feature and viscous nature. HA is a ubiquitous compound found in almost all biological tissues and fluids. So far, HA grades are produced by biotechnology processes, while in the human organism it is a major component of the extracellular matrix (ECM) in brain tissue, synovial fluid, vitreous humor, cartilage and skin. Indeed, HA is capable of forming hydrogels, polymer crosslinked networks that are very hygroscopic. Based on these considerations, we propose an overview of HA-based scaffolds developed for brain cancer treatment, central and peripheral nervous systems, discuss their relevance and identify the most successful developed systems.     

Identification of a Maturation Plasma Cell Index through a Highly Sensitive Droplet Digital PCR Assay Gene Expression Signature Validation in Newly Diagnosed Multiple Myeloma Patients

DNA microarrays and RNA-based sequencing approaches are considered important discovery tools in clinical medicine. However, cross-platform reproducibility studies undertaken so far have highlighted that microarrays are not able to accurately measure gene expression, particularly when they are expressed at low levels. Here, we consider the employment of a digital PCR assay (ddPCR) to validate a gene signature previously identified by gene expression profile. This signature included ten Hedgehog (HH) pathways’ genes able to stratify multiple myeloma (MM) patients according to their self-renewal status. Results show that the designed assay is able to validate gene expression data, both in a retrospective as well as in a prospective cohort. In addition, the plasma cells’ differentiation status determined by ddPCR was further confirmed by other techniques, such as flow cytometry, allowing the identification of patients with immature plasma cells’ phenotype (i.e., expressing CD19+/CD81+ markers) upregulating HH genes, as compared to others, whose plasma cells lose the expression of these markers and were more differentiated. To our knowledge, this is the first technical report of gene expression data validation by ddPCR instead of classical qPCR. This approach permitted the identification of a Maturation Index through the integration of molecular and phenotypic data, able to possibly define upfront the differentiation status of MM patients that would be clinically relevant in the future.