Statistical approach for evolutionary relationship of alpha-conotoxins and members of insulin-superfamily

Similar conserved structures appear in apparently unrelated protein families. Thus, the superfamily of insulin shows an evolutionary relationship with the alpha-conotoxins of marine fish-hunting snails as indicated by methods of protein comparison. In order to reach statistical significance, the A-chains of different insulins, insulin-like growth factors, relaxins, insulin related peptides from invertebrates were drawn for comparison. These data were correlated with sequences from randomly chosen proteins. The alpha-conotoxins show identity scores up to 37.5% and similarity up to 56.2% toward the members of the insulin-superfamily. These scores conform to values achieved by comparing the relaxin and the insulin/IGF-sequences. The data show clearly that the identity and similarity values obtained in the comparison with the insulins are significantly higher than the scores of randomly chosen protein primary structures. According to our calculated data, this hormone system regulating metabolism and growth in vertebrates and the mentioned toxin-receptor system share the same evolutionary ancestor. However, this statistical approach has to be substantiated on gene level.     

Grasping with hydraulic fingers-an example of mechatronics

Grasping, regrasping, and manipulation with an artificial hand being composed of several fingers require control strategies to assure reasonable cooperation of the fingers with respect to an object. This paper presents such concepts. They are verified by a hand with four hydraulic fingers, which together with control and power electronics, represent a typical mechatronic system.     

Electrical polarization in the osteon-system under mechanical stress (author's transl)

The results of a model, designed to estimate the electrical polarization of the mineralized collagen fribril in the osteon-system caused by mechanical stresses are presented. These are potential differences in the mV-range between neighbouring osteon-canals with different orientation of the fibrils in the wall of the canal, local dependent potentials in the cross-sectional area of the osteon-canal and the local dependent radial component of the dielectric displacement within the lamella system, especially nearby the osteocytes.     

The complexity of induced minors and related problems

The computational complexity of a number of problems concerning induced structures in graphs is studied, and compared with the complexity of corresponding problems concerning non-induced structures. The effect on these problems of restricting the input to planar graphs is also considered. The principal results include: (1) Induced Maximum Matching and Induced Directed Path are NP-complete for planar graphs, (2) for every fixed graphH, InducedH-Minor Testing can be accomplished for planar graphs in time0(n), and (3) there are graphsH for which InducedH-Minor Testing is NP-complete for unrestricted input. Some useful structural theorems concerning induced minors are presented, including a bound on the treewidth of planar graphs that exclude a planar induced minor.The research of the first author was supported by the U.S. Office of Naval Research under Contract N00014-88-K-0456, by the U.S. National Science Foundation under Grant MIP-8603879, and by the National Science and Engineering Research Council of Canada. The second author acknowledges the support of the U.S. Office of Naval Research when visiting the University of Idaho in spring 1990. Some results were also obtained during a visit to the University of Cologne in fall 1990.