Recent advances in the synthesis of metal nanoparticles (MeNPs), and more specifically gold nanoparticles (AuNPs), have led to tremendous expansion of their potential applications in different fields, ranging from healthcare research to microelectronics and food packaging. The properties of functionalised MeNPs can be fine-tuned depending on their final application, and subsequently, these properties can strongly modulate their biological effects. In this review, we will firstly focus on the impact of MeNP characteristics (particularly of gold nanoparticles, AuNPs) such as shape, size, and aggregation on their biological activities. Moreover, we will detail different in vitro and in vivo assays to be performed when cytotoxicity and biocompatibility must be assessed. Due to the complex nature of nanomaterials, conflicting studies have led to different views on their safety, and it is clear that the definition of a standard biosafety label for AuNPs is difficult. In fact, AuNPs’ biocompatibility is strongly affected by the nanoparticles’ intrinsic characteristics, biological target, and methodology employed to evaluate their toxicity. In the last part of this review, the current legislation and requirements established by regulatory authorities, defining the main guidelines and standards to characterise new nanomaterials, will also be discussed, as this aspect has not been reviewed recently. It is clear that the lack of well-established safety regulations based on reliable, robust, and universal methodologies has hampered the development of MeNP applications in the healthcare field. Henceforth, the international community must make an effort to adopt specific and standard protocols for characterisation of these products. 相似文献
Two series samples of Iron Oxide nanoparticles doped with nickel and cobalt with different doping values (x?=?0.01; 0.03; 0.05 and 0.07), were successfully synthesized by using sol–gel method, and then they were characterized by X-ray diffraction, scanning electron and vibrating sample magnetometer (VSM). X-ray diffraction analysis of two series samples showed the formation α-Fe2O3 nanoparticles, accompanied by two phases iron spinels, CoFe2O4 and NiFe2O4. In addition, the variations in grain size were observed for both two series. The observation by scanning electron microscopy reveals a change in the morphology of the grains of all the samples doped, which confirm the cobalt and nickel effect on the morphology of iron oxide nanoparticles. Magnetic measurements which were measured by VSM showed significant magnetic parameters such as coercivity and magnetization besides the ferromagnetic behavior of both two series doped with Cobalt and Nickel.
This paper considers the job-shop problem with release dates and due dates, with the objective of minimizing the total weighted tardiness. A genetic algorithm is combined with an iterated local search that uses a longest path approach on a disjunctive graph model. A design of experiments approach is employed to calibrate the parameters and operators of the algorithm. Previous studies on genetic algorithms for the job-shop problem point out that these algorithms are highly depended on the way the chromosomes are decoded. In this paper, we show that the efficiency of genetic algorithms does no longer depend on the schedule builder when an iterated local search is used. Computational experiments carried out on instances of the literature show the efficiency of the proposed algorithm. 相似文献
In this paper, a software/hardware High-level Synthesis (HLS) design is proposed to compute the Adaptive Vector Median Filter (AVMF) in real-time. In fact, this filter is known by its excellent impulsive noise suppression and chromaticity conservation. The software (SW) study of this filter demonstrates that its implementation is too complex. The purpose of this work is to study the impact of using an HLS tool to design ideal floating-point and optimized fixed-point hardware (HW) architectures for the AVMF filter using square root function (ideal HW) and ROM memory (optimized HW), respectively, to select the best HLS architectures and to design an efficient HLS software/hardware (SW/HW) embedded AVMF design to achieve a trade-off between the processing time, power consumption and hardware cost. For that purpose, some approximations using ROM memory were proposed to perform the square root and develop a fixed-point AVMF algorithm. After that, the best solution generated for each HLS design was integrated in the SW/HW environment and evaluated under ZC702 FPGA platform. The experimental results showed a reduction of about 65% and 98% in both the power consumption and processing time for the ideal SW/HW implementation relative to the ideal SW implementation for an AVMF filter with the same image quality, respectively. Moreover, the power consumption and processing time of the optimized SW/HW are 70% and 97% less than the optimized SW implementation, respectively. In addition, the Look Up Table (LUTs) percentage, power consumption and processing time used by the optimized SW/HW design are improved by nearly 45%, 18% and 61% compared the ideal SW/HW design, respectively, with slight decrease in the image quality. 相似文献
Microsystem Technologies - We develop an analytical formulation to calculate the induced resonance frequency shifts of an electrostatically actuated torsional microsensor due to an added bio-mass... 相似文献
A detailed theoretical treatment of a one- (1D) and three-dimensional (3D) photothermal deflection (PTD) technique is presented. Important effects of the probe beam size occur in PTD experiments when the radius of this beam is of the order of magnitude of the thermal diffusion length. The calculation of this effect is checked by experiments in paraffin oil at low modulation frequency as well as for 1D and for 3D. In this last case, we have considered two kinds of deflection: normal and transverse, and we have studied their variation for different values of the pump beam radius. The coincidence between theoretical and experimental curves confirms the validity of our theoretical model. 相似文献
We describe for the first time to our knowledge the performance for a linear array of tapered laser diodes with both fast- and slow-axis collimation using a microlens for fast-axis collimation and a laser-written phase plate for slow-axis collimation and correction of the residual fast-axis errors from lens aberrations, thermal lensing, astigmatism, pointing errors, and other wavefront distortions. The phase plate leads to M(2) factor reductions of 1.5 for the lensed array following the fast axis and 2.6 for the whole bar following the slow axis. 相似文献