The effect of sexual hormone abnormalities on proximal femur bone mineral density in hemodialysis patients and the possible role of RANKL

Sexual hormone concentrations are commonly affected in chronic renal failure. The contribution of sex steroids to bone turnover regulation implies that sex steroid's dysfunction may be implicated in the emergence of renal osteodystrophy. This study was conducted to evaluate sex steroids and gonadotrophins in hemodialysis (HD) patients and to investigate their role in bone homeostasis in concert with other hormones and cytokines. Bone mineral density (BMD) at the proximal femur and intact parathyroid hormone (iPTH), osteoprotegerin, soluble receptor activator of NF-kappaB ligand (sRANKL), prolactin, total testosterone, estradiol, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured in serum samples in 42 patients, 21 men and 21 women, on maintenance HD therapy. Possible associations between clinical characteristics, biochemical parameters, and BMD values were investigated. In male HD patients, the testosterone concentration declined significantly with aging, whereas the estradiol level increased with longer duration of HD. Concurrently, testosterone correlated negatively with sRANKL concentrations (r=-0.520, p=0.016). Luteinizing hormone levels in male patients demonstrated statistically significant negative correlations with BMD values of the proximal femur. In the entire cohort of patients, FSH and LH were negatively associated with absolute values of proximal femur BMD. Gonadotrophin and sexual hormone concentrations in HD patients are associated with bone mineral status and consequently their derangements appear to contribute to the development of bone composition abnormalities in different types of renal osteodystrophy. Furthermore, testosterone's association with sRANKL levels in male HD patients suggests that RANKL may mediate the effect of testosterone on bone metabolism in these patients.     

Resource provision ego-networks in small Greek construction firms

The prominence of small professional service providers in a fragmented construction sector in part relates to the ability to provide competitive advantage through the provision of a personalized service in a context where diseconomies of scale prevail. The Greek construction industry is particularly representative of this trend towards the dominance of small businesses. The small business owner relies upon their ability to secure critical resources through personal networks which provide information, advice, funding and brokerage. Resource provision ego-networks are investigated structurally using social network analysis. A multiple case study approach is employed with comparative social network analysis, focusing on the density of ego-networks and the prominence of resource providers and associated subgroups. Findings show that commercial development activity is promoted through high-density networks, which infers that higher levels of connectivity characterize networks operating in environments of uncertainty. As these critical resource networks mature, they appear to rely less on strong ties and temporary formal project networks. Contractual relationships appear to co-exist with reciprocal flows of resources outside the contract's scope.

L'importance des petits prestataires de services professionnels dans un secteur du bâtiment qui est fragmenté tient pour partie à la capacité à assurer un avantage concurrentiel par la fourniture d'un service personnalisé dans un contexte où les déséconomies d'échelle prévalent. L'industrie grecque du bâtiment est particulièrement représentative de cette tendance à la dominance des petites entreprises. Le propriétaire d'une petite entreprise s'appuie sur sa capacité à garantir des ressources critiques par des réseaux personnels qui fournissent des informations, des conseils, du financement et des services de courtage. Les ego-réseaux prestataires de ressources sont examinés d'un point de vue structurel en utilisant une analyse des réseaux sociaux. Il est employé une approche basée sur une étude de cas multiples s'accompagnant d'une analyse comparative des réseaux sociaux, centrée sur la densité des ego-réseaux et sur l'importance des prestataires de ressources et des sous-groupes associés. Les résultats constatés montrent que la promotion des activités de développement commercial se fait par les réseaux haute densité, ce qui induit que des niveaux supérieurs de connectivité caractérisent les réseaux fonctionnant dans des contextes marqués par l'incertitude. Au fur et à mesure que ces réseaux de ressources critiques mûrissent, ils semblent moins s'appuyer sur des liens forts et des réseaux temporaires en rapport avec des projets formels. Il apparaît que les relations contractuelles coexistent avec des flux de ressources réciproques en dehors du champ du contrat.

ego-réseaux ou réseaux personnels, activité entrepreneuriale, réseaux prestataires de ressources, PME du bâtiment, analyse des réseaux sociaux     

CorpWiki: A self-regulating wiki to promote corporate collective intelligence through expert peer matching

One of the main challenges that organizations face nowadays, is the efficient use of individual employee intelligence, through machine-facilitated understanding of the collected corporate knowledge, to develop their collective intelligence. Web 2.0 technologies, like wikis, can be used to address the above issue. Nevertheless, their application in corporate environments is limited, mainly due to their inability to ensure knowledge creation and assessment in a timely and reliable manner. In this study we propose CorpWiki, a self-regulating wiki system for effective acquisition of high-quality knowledge content. Inserted articles undergo a quality assessment control by a large number of corporate peer employees. In case the quality is inadequate, CorpWiki uses a novel expert peer matching algorithm (EPM), based on feed-forward neural networks, that searches the human network of the organization to select the most appropriate peer employee who will improve the quality of the article. Performance evaluation results, obtained through simulation modeling, indicate that CorpWiki improves the final quality levels of the inserted articles as well as the time and effort required to reach them. The proposed system, combining machine-learning intelligence with the individual intelligence of peer employees, aims to create new inferences regarding corporate issues, thus promoting the collective organizational intelligence.     

Gender issues in technology use: Perceived social support,computer self-efficacy and value beliefs,and computer use beyond school

In this study, we examined relations between outside school computer experiences, perceived social support for using computers, and self-efficacy and value beliefs about computer learning for 340 Greek elementary school boys and girls. Participants responded to a questionnaire about their access to computer use outside school (e.g. frequency of use and nature of activities), perceived parental and peer support, and computer self-efficacy and value beliefs. Although almost all students used computers outside school, there were significant gender differences in frequency and type of computer use. Also, boys reported more perceived support from their parents and peers to use computers and more positive computer self-efficacy and value beliefs than girls. Parental support and, to a lesser extent, peer support were the factors more strongly associated with boys’ and girls’ computer self-efficacy and value beliefs, while home computer access was not related to students’ motivation. Our findings highlight the role of socialization in the gender gap in computing and the need for research and educational interventions that focus on the social practices that communicate gendered expectations to young boys and girls.     

Macroscopic and microscopic techno-economic analyses highlighting aspects of 5G transport network deployments

Photonic Network Communications - 5G networks will comprise multiple, versatile infrastructures at finest granularity consisting of multiple disaggregated pools of network, compute and storage...     

Performance of Pilot-scale Constructed Floating Wetlands in the Removal of Nutrients and Pesticides

Aiming to evaluate the efficacy of constructed floating wetlands (CFW) in removing agrochemicals (nutrients and pesticides), a series of experiments were run continuously for a 16-week period in pilot-scale CFW systems to study the effect of two aquatic plant species (duckweed and water hyacinth) and climatic parameters. The CFW systems were loaded daily with agricultural polluted water containing a fertilizer and five pesticides, whose concentrations and removal efficiencies were measured in the experiments. Average nutrient and pesticide reductions varied from 27.4% to 83.6% and from 12.4% to 42.7%, respectively. The two plants performed almost equally well. High temperatures and increased solar radiation significantly contributed to increased removal performance. The results suggest the use of CFW systems as effective and low-cost agricultural pollution control technologies.

     

Phase relations in the calcium carbonate/ammonium phosphate system under aqueous conditions and 25°C

A theoretical and experimental approach was applied to investigate phase relations in a system containing calcium carbonate and different ammonium phosphate solutions. Using laboratory experiments and thermodynamic modeling, this paper provides an insight into the formation of stable phase assemblages in the calcium carbonate and mono-, di-, triammonium phosphate aqueous system . Focus is placed on the morphological and mineralogical characterization and thermodynamic calculation of calcium phosphates precipitating due to the reaction between the calcium carbonate and ammonium phosphate solutions. Correlations between the formed stable calcium phosphate phases and the ammonium phosphate precursors are provided. Advantages and limitations of various analytical and modeling techniques used in this study such as geochemical equilibrium-based modeling, X-ray diffraction, scanning electron microscopy, and thermal analysis, are critically evaluated. Additionally, possible impacts of the ammonium phosphate solution type on the kinetics of phase transformations are discussed.     

Direct laser writing of microoptical structures using a Ge-containing hybrid material

We present our investigations into the direct laser writing of a novel germanium-containing hybrid sol–gel photosensitive material for optical applications at micro scale. We employ this material in the fabrication of photonic micro-structures, such as aspheric lenses and prisms; these are well-shaped and provided good optical performance. The material exhibits good transparency and structurability, and three-dimensional structures with sub-100 nm resolution are achieved. We demonstrate the suitability of the direct laser writing method for the rapid production of custom shaped microoptical components. Since germanium glasses are widely used in fiber optics, the combination of direct laser writing with this specially designed, functional material opens an interesting way in fabricating structures for controlling light flow.     

Residential indoor air quality interventions through a social-ecological systems lens: A systematic review

Indoor air quality (IAQ) is an important consideration for health and well-being as people spend most of their time indoors. Multi-disciplinary interest in IAQ is growing, resulting in more empirical research, especially in affordable housing settings, given disproportionate impacts on vulnerable populations. Conceptually, there is little coherency among these case studies; they traverse diverse spatial scales, indoor and outdoor environments, and populations, making it difficult to implement research findings in any given setting. We employ a social-ecological systems (SES) framework to review and categorize existing interventions and other literature findings to elucidate relationships among spatially and otherwise diverse IAQ factors. This perspective is highly attentive to the role of agency, highlighting individual, household, and organizational behaviors and constraints in managing IAQ. When combined with scientific knowledge about the effectiveness of IAQ interventions, this approach favors actionable strategies for reducing the presence of indoor pollutants and personal exposures.     

Reevaluation of bioactivity and antioxidant activity of <Emphasis Type=Italic>Myrtus communis</Emphasis> extract before and after encapsulation in liposomes

The antioxidant and antimicrobial activity of Myrtus communis extract was determined before and after its encapsulation in liposomes of different composition. Evaluation of the sunflower oil oxidation by the Rancimat stability test and malondialdehyde formation by HPLC were used to measure the antioxidant action in comparison with common commercial antioxidants, such as butylated hydroxytoluene and α-tocopherol. The thermal-oxidative decomposition of the samples, the modification of the main transition temperature for the lipid mixture and the splitting of the calorimetric peak in the presence of the antioxidants were studied by differential scanning calorimetry. The size and the surface charge of liposomes were also studied. The extract showed antioxidant and antimicrobial activity. Αt concentrations up to 160 ppm, the extract showed superior activity than α-tocopherol. When the extract was encapsulated in liposomes, its antioxidant as well as its antimicrobial activity proved to be superior from that of itself in pure form.