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31.
Ultrastructure of the digestive tract in neotropical carnivorous catfish Hemisorubim platyrhynchos (Valenciennes, 1840) (Siluriformes,Pimelodidae) 下载免费PDF全文
32.
Alessia Mariano Irene Bigioni Anna Scotto dAbusco Alessia Baseggio Conrado Simonetta Maina Antonio Francioso Luciana Mosca Mario Fontana 《International journal of molecular sciences》2022,23(1)
Pheomelanin is a natural yellow-reddish sulfur-containing pigment derived from tyrosinase-catalyzed oxidation of tyrosine in presence of cysteine. Generally, the formation of melanin pigments is a protective response against the damaging effects of UV radiation in skin. However, pheomelanin, like other photosensitizing substances, can trigger, following exposure to UV radiation, photochemical reactions capable of modifying and damaging cellular components. The photoproperties of this natural pigment have been studied by analyzing pheomelanin effect on oxidation/nitration of tyrosine induced by UVB radiation at different pH values and in presence of iron ions. Photoproperties of pheomelanin can be modulated by various experimental conditions, ranging from the photoprotection to the triggering of potentially damaging photochemical reactions. The study of the photomodification of l-Tyrosine in the presence of the natural pigment pheomelanin has a special relevance, since this tyrosine oxidation/nitration pathway can potentially occur in vivo in tissues exposed to sunlight and play a role in the mechanisms of tissue damage induced by UV radiation. 相似文献
33.
Juan Carlos Fernndez-Martín Ana María Espinosa-Oliva Irene García-Domínguez Isaac Rosado-Snchez Yolanda M. Pacheco Rosario Moyano Jos G. Monterde Jos Luis Venero Rocío M. de Pablos 《International journal of molecular sciences》2022,23(3)
Lipopolysaccharide (LPS)-induced endotoxemia induces an acute systemic inflammatory response that mimics some important features of sepsis, the disease with the highest mortality rate worldwide. In this work, we have analyzed a murine model of endotoxemia based on a single intraperitoneal injection of 5 mg/kg of LPS. We took advantage of galectin-3 (Gal3) knockout mice and found that the absence of Gal3 decreased the mortality rate oflethal endotoxemia in the first 80 h after the administration of LPS, along with a reduction in the tissular damage in several organs measured by electron microscopy. Using flow cytometry, we demonstrated that, in control conditions, peripheral immune cells, especially monocytes, exhibited high levels of Gal3, which were early depleted in response to LPS injection, thus suggesting Gal3 release under endotoxemia conditions. However, serum levels of Gal3 early decreased in response to LPS challenge (1 h), an indication that Gal3 may be extravasated to peripheral organs. Indeed, analysis of Gal3 in peripheral organs revealed a robust up-regulation of Gal3 36 h after LPS injection. Taken together, these results demonstrate the important role that Gal3 could play in the development of systemic inflammation, a well-established feature of sepsis, thus opening new and promising therapeutic options for these harmful conditions. 相似文献
34.
Filippo Crimì Emilio Quaia Giulio Cabrelle Chiara Zanon Alessia Pepe Daniela Regazzo Irene Tizianel Carla Scaroni Filippo Ceccato 《International journal of molecular sciences》2022,23(2)
Adrenal incidentalomas (AIs) are incidentally discovered adrenal neoplasms. Overt endocrine secretion (glucocorticoids, mineralocorticoids, and catecholamines) and malignancy (primary or metastatic disease) are assessed at baseline evaluation. Size, lipid content, and washout characterise benign AIs (respectively, <4 cm, <10 Hounsfield unit, and rapid release); nonetheless, 30% of adrenal lesions are not correctly indicated. Recently, image-based texture analysis from computed tomography (CT) may be useful to assess the behaviour of indeterminate adrenal lesions. We performed a systematic review to provide the state-of-the-art of texture analysis in patients with AI. We considered 9 papers (from 70 selected), with a median of 125 patients (range 20–356). Histological confirmation was the most used criteria to differentiate benign from the malignant adrenal mass. Unenhanced or contrast-enhanced data were available in all papers; TexRAD and PyRadiomics were the most used software. Four papers analysed the whole volume, and five considered a region of interest. Different texture features were reported, considering first- and second-order statistics. The pooled median area under the ROC curve in all studies was 0.85, depicting a high diagnostic accuracy, up to 93% in differentiating adrenal adenoma from adrenocortical carcinomas. Despite heterogeneous methodology, texture analysis is a promising diagnostic tool in the first assessment of patients with adrenal lesions. 相似文献
35.
Irene B. Zabala-Díaz Vesela I. Chalova Steven C. Ricke 《Sensing and Instrumentation for Food Quality and Safety》2007,1(2):55-61
The importance of lysine determination in feed materials is crucial for the feed industry because this amino acid can be limiting
in many of the cereal materials used for animal feeds. The bacterial gene induction-based assay developed in this study aimed
to measure lysine bioavailability in feeds as an alternative analytical method for animal assays. The advantages of a gene
induction-based approach include rapid and quantitative estimation of many samples and results that relate a bacterial response
to a biological response observed in animals. A whole-cell biosensor strain was constructed using a fluorescent E. coli strain that has an inducible fluorescent phenotype sensitive to extracellular lysine contents. A genetic fusion that links
the promoter of cad operon with a green fluorescent protein encoding gene (gfp) was constructed, and a fluorescent assay was developed. A standard lysine curve (R2 = 0.95) was generated and used for lysine bioavailability quantification of four feed ingredients (whole egg protein, blood-,
soybean-, and meat and bone meal). Quantities as low as 50 μg/ml protein of digested samples were sufficient for analyses
using the biosensor, except for meat and bone meal. Because of the low levels of free lysine in non-digested samples, fluorescence
of these protein sources containing lower than 500 μg/ml protein was not detected (except for soybean meal). The results using
enzymatically digested protein sources showed that the test strain emitted a fluorescent response that was proportional to
the level of lysine present in the feed samples. 相似文献
36.
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38.
Nae-Lih Wu Li-Fu Wu Irene A. Rusakova Alejandro Hamed Alexader P. Litvinchuk 《Journal of the American Ceramic Society》1999,82(1):67-73
Upon consecutive heat treatments at increasing temperatures, the microstructure of solution–sol–gel-derived stannic oxide (SnO2 ) xerogel evolves in three stages: (I) below 300°C, characterized by extensive dehydroxylation and gel shrinkage with little grain growth and surface loss; (II) between 300° and 500°C, by extensive crystallization, leading to dramatic surface loss (by 70%); and (III) above 500°C, by grain growth. Concurrently, the UV-absorption edge shows red shifts during stages I and II and blue shifts during stage III, resulting in distinct color variations. The edge displacement bears a close correlation with a Raman "defect band" at ∼305–328 cm−1 . 相似文献
39.
Anders Andersson Vassilis Gekas Irene Lind Fernanda Oliveira Rickard Öste Dr. Jose Miguel Aguilfra 《Critical reviews in food science and nutrition》1994,34(3):229-251
Preheating potatoes at 50 to 80°C has a firming effect on the cooked potato tissue. This effect is particularly pronounced at a preheating temperature of 60 to 70°C followed by cooling. Several theories have been presented in the literature to explain this firming effect: retrogradation of starch, leaching of amylose, stabilization of the middle lamellae and cell walls by the activation of the pectin methylesterase (PME) enzyme, and by the release of calcium from gelatinized starch and the formation of calcium bridges between pectin molecules. Most probably, none of these theories alone can explain the phenomenon and more than one mechanism seems to be involved. Some of these mechanisms seem to be interdependent. As an example, calcium could be considered as a link all the way through release after starch gelatinization to cross‐linking pectin substances in the cell wall and the middle lamellae, which has been demethylated by the PME enzyme. More research and “clear cut” experiments are needed in order to elucidate the role of each mechanism, especially which of them is the main contributor to the process of firming. Most probably, the calcium‐pectin‐PME mechanism plays a secondary role, that is, it only retards the collapse of the tissue structure that would otherwise occur during the final heating without preheating, and it is not the main factor of firmness. 相似文献