Simple multichannel system for the measurement of the net water flux across biological tissues

This paper describes the development of a simple system for measurement of net water movement through biological membrane barriers. The system is based on the detection of a water meniscus inside a polyethylene tube, which reflects the water movement inside one hemichamber of a modified Ussing chamber containing a membrane barrier. The detection device consists of a commercial computer-controlled flat bed scanner and specifically developed software. This system allows one to perform a relatively high number of individual experiments per physical unit. It is a flexible and affordable device, which allows comparatively more information per unit to be obtained than previously described methods.     

The Great Lakes Region and Bulk Water Exports

Abstract

The article provides an overview of the latest developments in the debate concerning the bulk water export of Great Lakes water. It examines the policy and legal dimensions of this new debate. The policy dimension focuses on the public attention and concern, in Canada, regarding bulk water removals from the Great Lakes basin. This concern has triggered the new Canadian federal legislation banning water exports from the region (Bill C-15). Is this a sign that the Canadian government now embraces a water conservation ethic? Is its position in line with the recent recommendations on the issue of the International Joint Commission (IJC), the joint body created by the United States and Canada to manage its shared waters? The attempt by investors to export water from the Great Lakes basin raises issues regarding Canada's obligations under international and regional trade agreements, most notably the General Agreement on Tariffs and Trade (GATT) and the North American Free Trade Agreement (NAFTA). The article examines the provisions of those two trade agreements in the context of the water export debate in Canada and concludes that increased clarity on Canada/US transboundary water issues is required.     

A note on stabilization of locally damped wave equations with time delay

In this paper, we consider the wave equation with internal distributed time delay and local damping in a bounded and smooth domain Ω⊂Rⁿ. When the local damping acts on a neighborhood of a suitable part of the boundary of Ω, we show that an exponential stability result holds if the coefficient of the delay term is sufficiently small.     

Parallel option pricing on GPU: barrier options and realized variance options

This paper shows two examples of how the analysis of option pricing problems can lead to computational methods efficiently implemented in parallel. These computational methods outperform ??general purpose?? methods (i.e., for example, Monte Carlo, finite differences methods). The GPU implementation of two numerical algorithms to price two specific derivatives (continuous barrier options and realized variance options) is presented. These algorithms are implemented in CUDA subroutines ready to run on Graphics Processing Units (GPUs) and their performance is studied. The realization of these subroutines is motivated by the extensive use of the derivatives considered in the financial markets to hedge or to take risk and by the interest of financial institutions in the use of state of the art hardware and software to speed up the decision process. The performance of these algorithms is measured using the (CPU/GPU) speed up factor, that is using the ratio between the (wall clock) times required to execute the code on a CPU and on a GPU. The choice of the reference CPU and GPU used to evaluate the speed up factors presented is stated. The outstanding performance of the algorithms developed is due to the mathematical properties of the pricing formulae used and to the ad hoc software implementation. In the case of realized variance options when the computation is done in single precision the comparisons between CPU and GPU execution times gives speed up factors of the order of a few hundreds. For barrier options, the corresponding speed up factors are of about fifteen, twenty. The CUDA subroutines to price barrier options and realized variance options can be downloaded from the website http://www.econ.univpm.it/recchioni/finance/w13. A?more general reference to the work in mathematical finance of some of the authors and of their coauthors is the website http://www.econ.univpm.it/recchioni/finance/.     

Self-Organising Maps: A new way to screen the level of satisfaction of dialysis patients

Evaluation of patient satisfaction has become an important indicator for assessing health care quality. Fresenius Medical Care (FME) as a global provider of dialysis services through its NephroCare network has a strong interest in monitoring patient satisfaction.The aim of the paper is to test and validate a methodology for detecting a residual area of low satisfaction in dialysis patients.The FME Patient Satisfaction Programme questionnaire was distributed to haemodialysis (HD) patients treated in 335 centers of its network. It contained 79 questions covering various satisfaction aspects regarding Dialysis Unit, Dialysis Arrangement, Nurses, Doctors, etc.To analyse the data provided by the questionnaire, the Self-Organising Map (SOM) method was used. SOM is a neural network model for clustering and projecting high-dimensional data into a low-dimensional space, preserving topological relationships of original high-dimensional data spaces.10,632 HD patients completed the questionnaire. Mean age was 63.05 ± 14.93 years with 56.69% males. Response rate was 66%. Overall level of satisfaction was 1.99 (range from ?3 to +3). On average patients were very satisfied with all issues. Nevertheless, a group of patients, around 60 years old, balanced gender ratio, whose level of satisfaction was lower than 1, were highlighted.In the NephroCare clinics patient satisfaction with service is rather high. While traditional analysis usually stops here, the SOM method allows identification of areas of potential improvement for specific patient groups.     

Support and precursor effects on the preparation of new heterogenized Pt/Sn catalysts for the selective hydroformylation of 1-pentene

New heterogenized Pt/Sn catalysts selective for the hydroformylation of 1-pentene have been synthesized. The complex cis-[PtCl₂(PPh₃)₂] and the SnCl₂.2H₂O or SnC₂O₄ precursors have been anchored on silica-, magnesia- and alumina-carriers. X-ray photoelectron spectroscopy was used to determine the surface composition and the nature of the anchored species. The hydroformylation activity was found to depend on the type of support and tin precursor used. Only the silica supported catalysts were active in the hydroformylation reaction. Samples prepared from SnCl₂-2H₂O were 200-fold more active than those prepared from SnC₂O₄. Selectivity ton-hexanal of the silica-supported catalyst prepared from SnCl₂-2H₂O was as high as 94.4% at 39.2% conversion of 1-pentene.     

Special section technical notes and correspondence. Min-max model predictive control of nonlinear systems using discontinuous feedbacks

This note proposes a model predictive control (MPC) algorithm for the solution of a robust control problem for continuous-time systems. Discontinuous feedback strategies are allowed in the solution of the min-max problems to be solved. The use of such strategies allows MPC to address a large class of nonlinear systems, including among others nonholonomic systems. Robust stability conditions to ensure steering to a certain set under bounded disturbances are established. The use of bang-bang feedbacks described by a small number of parameters is proposed, reducing considerably the computational burden associated with solving a differential game. The applicability of the proposed algorithm is tested to control a unicycle mobile robot.     

A survey of QoS architectures

Over the past several years there has been a considerable amount of research within the field of quality-of-service (QoS) support for distributed multimedia systems. To date, most of the work has been within the context of individual architectural layers such as the distributed system platform, operating system, transport subsystem and network layers. Much less progress has been made in addressing the issue of overall end-to-end support for multimedia communications. In recognition of this, a number of research teams have proposed the development of QoS architectures which incorporate QoS-configurable interfaces and QoS driven control and management mechanisms across all architectural layers. This paper examines the state-of-the-art in the development of QoS architectures. The approach taken is to present QoS terminology and a generalized QoS framework for understanding and discussing QoS in the context of distributed multimedia systems. Following this, we evaluate a number of QoS architectures that have emerged in the literature.