Analysis of the interface and bond strength of resin-based endodontic cements to root dentin

This study evaluated by scanning electron microscopy the interface between root dentin and resin cements, with or without additional application of a dual-cured one-step self-etching dentin adhesive. In addition, the push-out bond strength of these materials to dentin was evaluated. Root canals of 50 maxillary human canines were subjected to biomechanical preparation and randomly assigned into five groups (n = 10) according to the obturation employed: I. AH Plus/gutta-percha; II. Endo-REZ/gutta-percha; III. Epiphany SE/Resilon; IV. Endo-REZ/gutta-percha + adhesive; and V. Epiphany SE/Resilon + adhesive. After obturation, two cross sections of 1.0 mm of each third of the root were obtained and analyzed by SEM and push-out. Data were analyzed by Kruskal-Wallis, Two-way ANOVA and Tukey's HSD tests (α = 5%). Significant differences occurred between scores for gap parameters and tags; greater tag formation resulted for Epiphany SE (P < 0.05). There were also significant differences between groups for the bond strength. AH Plus (1.24 ± 0.70) showed higher values (P < 0.05) compared to groups II (0,17 ± 0.19), III (0.10 ± 0.06), IV (0.09 ± 0.08), and V (0.06 ± 0.03), which were statistically similar (P > 0.05). There was no significant difference between the root thirds (P > 0.05). It was concluded that the use of a self-etching adhesive system did not improve the adhesion of resin-based sealers to dentin and that AH Plus showed better bond strength when compared to other cements.     

Using Broadcast Networks to Create On-demand Extremely Large Scale High-throughput Computing Infrastructures

A growing number of very simple parallel applications can benefit from the availability of very large computing resource pools that are exploited in an opportunistic way to considerably speed up the processing of these applications. In particular, many applications can scale out to take advantage of the availability of thousands, or even millions, of processors that can be simultaneously used. Some large-scale distributed computing infrastructures (DCI) have already been successfully assembled to this end. However, these DCI are normally designed to cater to specific kinds of applications, and their assemblage is not only costly, but also time consuming. We propose a novel architecture, named OddCI (On-demand DCI), for the cheap, fast and on-demand instantiation and dismantle of very large DCI. These characteristics allow application users to dynamically commission DCI that can cost-effectively be customized to their particular needs, and disposed after being used. Our approach leverages on broadcast communication as an efficient mechanism to enable aggregation of geographically distributed computing resources, including millions of non-traditional processing devices such as mobile phones, and digital television (DTV) receivers. We discuss how the proposed architecture can be implemented on top of a network of DTV receivers, providing evidences of both the technical, as well as the operational feasibility of the OddCI architecture.     

Plasticization of poly(3-hydroxybutyrate) with triethyl citrate: Thermal and mechanical properties,morphology, and kinetics of crystallization

Poly(3-hydroxybutyrate) (PHB), is one important biopolymer and a promising alternative to petroleum-based plastics. In this article, formulations of PHB and triethyl citrate (TEC) as plasticizer were prepared by melt extrusion. The effect of TEC on the mechanical, thermal, and morphological properties of PHB was investigated by tensile tests, impact resistance, dynamic-mechanical analysis, differential scanning calorimetry, polarized optical microscopy, and small- and wide-angle X-ray scattering. TEC acted as an efficient plasticizer for PHB, imparting gradual changes in the properties as the mass fraction of TEC increased. A reduction in the elastic modulus, an increase in the intensity of β relaxation indicated a higher capacity of mechanical energy dissipation for the formulations containing higher mass fractions of TEC. TEC reduced its glass transition and melting temperatures, contributing to the increase of the processing window of the temperature and minimizing thermal degradation of PHB. TEC had a strong influence on the kinetics of crystallization, the morphology of the spherulites, and the crystalline structural parameters, such as long period, crystalline lamella, and interlamellar amorphous region thicknesses. Our study clarifies how the morphology of the PHB crystalline phase evolves in the presence of the plasticizer and with the time of crystallization.     

Single and hybrid organoclay-filled PLA nanocomposites: Mechanical properties,viscoelastic behavior and fracture toughening mechanism

Poly (lactic acid) (PLA) nanocomposites based on single and hybrid organic-modified montmorillonites were previously studied in terms of their morphological, thermal and fire performance. As surfactants of the organoclays influenced the compatibility between the nanofillers and PLA with different degrees of clay platelets dispersion, the present work investigated the effect of these features in the mechanical properties of PLA nanocomposites. PLA nanocomposites specimens were analyzed by dynamic-mechanical-thermal analysis, which pointed out changes in the viscoelastic behavior of the materials by the incorporation of the organoclays, namely the increase of the storage modulus due to polymer chains movements restriction and reinforcement effects associated with the dispersion of the nanofillers. Flexural and impact testing showed that hybrid organomontmorillonites containing ester ammonium and ethoxylated amine improved PLA's ductility, toughness and impact resistance. This behavior was explained by the high level of compatibility and interaction between the surfactants and PLA chains due to the polar groups in their structures. These organoclays caused a transition on PLA's fracture from brittle to ductile in a way that the toughening mechanism was explained by crazing and multi-shear banding induced by the plasticized interfacial region around these organoclays.     

Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy

Amyotrophic lateral sclerosis (ALS) is a fatal neurological condition where motor neurons (MNs) degenerate. Most of the ALS cases are sporadic (sALS), whereas 10% are hereditarily transmitted (fALS), among which mutations are found in the gene that codes for the enzyme superoxide dismutase 1 (SOD1). A central question in ALS field is whether causative mutations display selective alterations not found in sALS patients, or they converge on shared molecular pathways. To identify specific and common mechanisms for designing appropriate therapeutic interventions, we focused on the SOD1-mutated (SOD1-ALS) versus sALS patients. Since ALS pathology involves different cell types other than MNs, we generated lymphoblastoid cell lines (LCLs) from sALS and SOD1-ALS patients and healthy donors and investigated whether they show changes in oxidative stress, mitochondrial dysfunction, metabolic disturbances, the antioxidant NRF2 pathway, inflammatory profile, and autophagic flux. Both oxidative phosphorylation and glycolysis appear to be upregulated in lymphoblasts from sALS and SOD1-ALS. Our results indicate significant differences in NRF2/ARE pathway between sALS and SOD1-ALS lymphoblasts. Furthermore, levels of inflammatory cytokines and autophagic flux discriminate between sALS and SOD1-ALS lymphoblasts. Overall, different molecular mechanisms are involved in sALS and SOD1-ALS patients and thus, personalized medicine should be developed for each case.     

Communication contention in task scheduling

Task scheduling is an essential aspect of parallel programming. Most heuristics for this NP-hard problem are based on a simple system model that assumes fully connected processors and concurrent interprocessor communication. Hence, contention for communication resources is not considered in task scheduling, yet it has a strong influence on the execution time of a parallel program. This paper investigates the incorporation of contention awareness into task scheduling. A new system model for task scheduling is proposed, allowing us to capture both end-point and network contention. To achieve this, the communication network is reflected by a topology graph for the representation of arbitrary static and dynamic networks. The contention awareness is accomplished by scheduling the communications, represented by the edges in the task graph, onto the links of the topology graph. Edge scheduling is theoretically analyzed, including aspects like heterogeneity, routing, and causality. The proposed contention-aware scheduling preserves the theoretical basis of task scheduling. It is shown how classic list scheduling is easily extended to this more accurate system model. Experimental results show the significantly improved accuracy and efficiency of the produced schedules.     

Socioeconomic Status and Insomnia.

This investigation compared the likelihood of insomnia and insomnia-related health consequences among individuals of different socioeconomic status. A random-digit dialing procedure was used to recruit at least 50 men and 50 women in each age decade from 20 to 80 + years old. Participants completed 2 weeks of sleep diaries as well as questionnaires related to fatigue, sleepiness, and psychological distress. Socioeconomic status was measured by education status assessed at 3 different levels: individual, household, and community. Results indicated that individuals of lower individual and household education were significantly more likely to experience insomnia even after researchers accounted for ethnicity, gender, and age. Additionally, individuals with fewer years of education, particularly those who had dropped out of high school, experienced greater subjective impairment because of their insomnia. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Preservation of cold‐stored guavas influenced by package materials

The objective of this study was to evaluate the influence of package materials on the preservation of cold‐stored ‘Kumagai’ guavas. The treatments were: PO2, co‐extruded polyolephinic film with gas injection (5% O₂/5% CO₂/N₂); PO3, co‐extruded polyolephinic film with gas injection (5% O₂/5% CO₂/N₂); LDPE, linear low density polyethylene film; LDPE‐gas, linear low density polyethylene film with gas injection (3% O₂/8% CO₂/N₂); PVC, polyvinylchloride stretch film; PO1, co‐extruded polyolephinic film and control: non‐packaged guavas. Guavas were stored at 10 ± 1°C/80–90% RH for 21 days, and then transferred to room temperature. Gas composition within the package headspace was analysed during storage and the physical and chemical characteristics of the guavas were evaluated daily during ripening. The modified atmosphere provided by PO1 film was insufficient to promote the benefit of senescence control. Although PVC provided an atmosphere close to that recommended, it did not preserve the colour and pulp firmness. PO2, PO3, LDPE and LDPE‐gas retarded the senescence process of the guavas during 21 days at 10°C plus 2 days at room temperature, but harmed the normal ripening of guavas in some aspects. This can be explained by reduced O₂ and elevated CO₂ levels within these four packages. None of the packages influenced the titratable acidity and the soluble solids, but they did harm ascorbic acid synthesis. Copyright © 2005 John Wiley & Sons, Ltd.     

On Task Scheduling Accuracy: Evaluation Methodology and Results

Many heuristics based on the directed acyclic graph (DAG) have been proposed for the static scheduling problem. Most of these algorithms apply a simple model of the target system that assumes fully connected processors, a dedicated communication sub-system and no contention for the communication resources. Only a few algorithms consider the network topology and the contention for the communication resources. This article evaluates the accuracy of task scheduling algorithms and thus the appropriateness of the applied models. An evaluation methodology is proposed and applied to a representative set of scheduling algorithms. The obtained results show a significant inaccuracy of the produced schedules. Analyzing these results is important for the development of more appropriate models and more accurate scheduling algorithms.