WIRES: A Methodology for Developing Workflow Applications

Workflow management systems are becoming a relevant support for a large class of business applications, and many workflow models as well as commercial products are currently available. While the large availability of tools facilitates the development and the fulfilment of customer requirements, workflow application development still requires methodological guidelines that drive the developers in the complex task of rapidly producing effective applications. In fact, it is necessary to identify and model the business processes, to design the interfaces towards existing cooperating systems, and to manage implementation aspects in an integrated way. This paper presents the WIRES methodology for developing workflow applications under a uniform modelling paradigm – UML modelling tools with some extensions – that covers all the life cycle of these applications: from conceptual analysis to implementation. High-level analysis is performed under different perspectives, including a business and an organisational perspective. Distribution, interoperability and cooperation with external information systems are considered in this early stage. A set of “workflowability” criteria is provided in order to identify which candidate processes are suited to be implemented as workflows. Non-functional requirements receive particular emphasis in that they are among the most important criteria for deciding whether workflow technology can be actually useful for implementing the business process at hand. The design phase tackles aspects of concurrency and cooperation, distributed transactions and exception handling. Reuse of component workflows, available in a repository as workflow fragments, is a distinguishing feature of the method. Implementation aspects are presented in terms of rules that guide in the selection of a commercial workflow management system suitable for supporting the designed processes, coupled with guidelines for mapping the designed workflows onto the model offered by the selected system.     

Neutron Scattering from the Flux Line Lattice in the Cubic (K, Ba)BiO 3 Superconductor

Small Angle Neutron Scattering has been used to observe diffraction from the flux line lattice in the fully isotropic (K, Ba)BiO ₃ high T _c superconductor. We show that the flux lines are ordered into a hexagonal lattice at low field (H < H _e 0.6T H _g (0) where H _g is the second order vortex glass transition field). The diffracted intensity continuously drops to zero as the field is increased towards H _e . Those observations are in good agreement with recent theoritical works which suggested that the formation of dislocations becomes favorable above H _e leading to a glassy structure. The field H _e lies close to the onset of the second peak in magnetization measurements indicating that this peak is related to the change in the vortex structure.     

Driving under the influence of cannabis: Links with dangerous driving, psychological predictors, and accident involvement

Driving under the influence of cannabis (DUIC) has become a growing concern. Studies investigating the impact of DUIC on traffic safety have shown evidence that, during the acute period of cannabis intoxication, cannabis diminishes driving faculties and is associated with an elevated risk of collision. However, DUIC drivers seem to exhibit a general reckless driving style that may contribute to an over-estimation of DUIC-related collisions among this group. In this study, we investigated DUIC drivers with respect to self-reported dangerous driving habits (e.g., risky driving, aggressive driving and negative emotional driving), behaviours observed in a driving simulator, psychological predictors and crash involvement. Results suggest that DUIC is associated with self-reported and observed risky driving and negative emotional driving. We also found that sensation seeking and impulsivity are independent psychological predictors of DUIC. Finally, a trend suggests that self-reported DUIC is associated with an increased risk of being involved in a car accident, after controlling for dangerous driving and demographic variables. Implications for interventions are discussed.     

Subsurface radar signal deconvolution

We present two methods of signal deconvolution for systems whose impulse response (wavelet function) can be explicitly determined, and where the goal is to locate short impulses in the presence of strong, reverberation-like interferences.The first method, which we call algebraic deconvolution, differs from other known techniques in two ways: first of all, explicit use of the wavelet function provides more powerful a priori knowledge than the autocorrelation or the power spectrum. Secondly, this method permits to flexibly trade off noise versus resolution.In the second method presented here, we use an analytical model (synthetic wavelet) of the system impulse response to determine an inverse filter.These methods have been developed for video pulse radar signals, and encouraging early results have been obtained.     

Fermentation by Amylolytic Lactic Acid Bacteria and Consequences for Starch Digestibility of Plantain, Breadfruit, and Sweet Potato Flours

The potential of tropical starchy plants such as plantain (Musa paradisiaca), breadfruit (Artocarpus communis), and sweet potato (Ipomoea batatas) for the development of new fermented foods was investigated by exploiting the capacity of some lactic acid bacteria to hydrolyze starch. The amylolytic lactic acid bacteria (ALAB) Lactobacillus plantarum A6 and Lactobacillus fermentum Ogi E1 were able to change the consistency of thick sticky gelatinized slurries of these starchy fruits and tubers into semiliquid to liquid products. Consequently, a decrease in apparent viscosity and an increase in Bostwick flow were observed. These changes and the production of maltooligosaccharides confirmed starch hydrolysis. Sucrose in sweet potato was not fermented by strain A6 and poorly fermented by strain Ogi E1, suggesting possible inhibition of sucrose fermentation. In all 3 starchy plants, rapidly digestible starch (RDS) was higher than slowly digestible starch (SDS) and resistant starch (RS) represented between 17% and 30% dry matter (DM). The digestibility of plantain was not affected by fermentation, whereas the RDS content of breadfruit and sweet potato decreased and the RS content increased after fermentation. Practical Application: The characteristics resulting from different combinations of gluten free starchy plants (plantain, breadfruit, sweet potato) and amylolytic lactic acid bacteria (ALAB) offer opportunities to develop new functional fermented beverages, mainly for breadfruit and sweet potato, after further investigation of their formulation, sensory attributes, nutritional, and prebiotic characteristics.     

Influence of new thermoplastic sizing agents on the mechanical behavior of poly(ether ketone ketone)/carbon fiber composites

In this study, unidirectional poly(ether ether ketone)/carbon fiber (CF) composite sheets were elaborated with unsized, epoxy‐sized, and thermoplastic‐sized CFs by hot‐press molding. The thermoplastic sizings that we used were poly(ether imide) (PEI) and poly(ether ketone ketone) oligomer aqueous dispersions. Scanning electron microscopy observation of the composites freeze fractures showed that unlike unsized or epoxy‐sized CFs, the thermoplastic sizings improved the interaction between the fibers and the matrix. A comparative study of the mechanical relaxations by dynamic mechanical analysis was carried out on the different composites before and after immersion in kerosene. At low temperature, the PEI sizing had a significant influence on the β relaxation, particularly after kerosene immersion. The thermoplastic sizings did not modify the glass‐transition temperature but improved the kerosene resistance on the composites. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42550.     

Accepting its random coil nature allows a partial NMR assignment of the neuronal Tau protein

A combined strategy to obtain a partial NMR assignment of the neuronal Tau protein is presented. Confronted with the extreme spectral degeneracy that the spectrum of this 441 amino acid long unstructured protein presents, we have introduced a graphical procedure based on residue type-specific product planes. Combining this strategy with the search for pairwise motifs, and combining the spectra of different Tau isoforms and even of peptides derived from the native sequence, we arrive at a partial assignment that is sufficient to map the interactions of Tau with its molecular partners. The obtained assignments equally confirm the absence of regular secondary structure in the isolated protein.     

Quantitative Analysis of Tau-Microtubule Interaction Using FRET

The interaction between the microtubule associated protein, tau and the microtubules is investigated. A fluorescence resonance energy transfer (FRET) assay was used to determine the distance separating tau to the microtubule wall, as well as the binding parameters of the interaction. By using microtubules stabilized with Flutax-2 as donor and tau labeled with rhodamine as acceptor, a donor-to-acceptor distance of 54 ± 1 Å was found. A molecular model is proposed in which Flutax-2 is directly accessible to tau-rhodamine molecules for energy transfer. By titration, we calculated the stoichiometric dissociation constant to be equal to 1.0 ± 0.5 µM. The influence of the C-terminal tails of αβ-tubulin on the tau-microtubule interaction is presented once a procedure to form homogeneous solution of cleaved tubulin has been determined. The results indicate that the C-terminal tails of α- and β-tubulin by electrostatic effects and of recruitment seem to be involved in the binding mechanism of tau.     

Design of an antibacterial gelatin based on a covalent protein–protein coupling

An antibacterial peptide (AMP), i.e., nisin, was covalently bound to gelatin through a protein–protein coupling. Various reaction conditions were tested to study and optimize parameters of grafting e.g., orientation and density of AMP, which could impact the final antibacterial activity of the modified biopolymer. Modification was investigated by Fourier transform infrared (FT‐IR) spectroscopy and zeta potential. The antibacterial activity of the nisin‐enriched gelatin was evaluated against two staphylococci bacterial strains, i.e., Staphylococus epidermidis and Staphylococcus aureus. A higher activity was found for gelatin modified at pH = 7.4 revealing an influence of the nisin orientation on the protein antibacterial property. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 41825.