Study of isolated apparent amniogenic limb deficiency in Hungary, 1975-1984

Rat brain cortex slices and synaptosomes preincubated with [3H]noradrenaline were used to investigate whether the NMDA-evoked noradrenaline release is modulated by agonists or antagonists at presynaptic alpha 2-adrenoceptors. In experiments on slices, noradrenaline and the preferential alpha-adrenoceptor agonists talipexole (former B-HT 920) and clonidine inhibited the NMDA-evoked tritium overflow whereas the selective alpha 1-adrenoceptor agonists cirazoline and methoxamine were ineffective. The alpha 2-adrenoceptor antagonists rauwolscine and idazoxan facilitated the NMDA-evoked tritium overflow whereas the preferential alpha 1-adrenoceptor antagonist prazosin was ineffective. The concentration-response curve of talipexole for its inhibitory effect on NMDA-evoked overflow was shifted to the right by idazoxan (apparent pA2 = 7.5). The EC50 of NMDA (97 mumol/l) for its stimulating effect on tritium overflow was not substantially changed by blockade of alpha 2-autoreceptors with 1 mumol/l rauwolscine (EC50 of NMDA in the presence of the alpha 2-adrenoceptor antagonist, 155 mumol/l), but the maximal overflow of tritium was increased 2.5 fold by this rauwolscine concentration. In experiments on synaptosomes, talipexole and noradrenaline inhibited the NMDA-evoked tritium overflow. The inhibitory effect of talipexole was abolished by idazoxan which, given alone, was ineffective, as was prazosin. Talipexole did also not produce an inhibition when tritium overflow was evoked by NMDA in the presence of omega-conotoxin GVIA 0.1 mumol/l; the latter, by itself, decreased the response to NMDA by about 55%.(ABSTRACT TRUNCATED AT 250 WORDS)     

A test piece for mechanical testing of fiber composite materials

This article describes a test piece that minimizes the spread of the results of testing of composite materials on a metal base by extension in the direction of a reinforcing fiber and, from the results, determines the mechanical properties of intermediate and finished products made of these materials.Translated from Izmeritel'naya Tekhnika, No. 10, pp. 39–40, October, 1993.     

Instrumentation for quality control and flaw detection of machine parts and materials by electrostatic induction

A computer-based measurement system has been designed and built for noncontact nondestructive measurement of charge and potential distribution on dielectric and semiconductor layers and films for various purposes.Translated from Izmeritel'naya Tekhnika, No. 8, pp. 49–51, August, 1993.     

Molecular cloning of a novel melanocortin receptor

Using the technique of the polymerase chain reaction primed with oligonucleotides based on the homologous transmembrane regions of seven transmembrane G protein-linked receptors, we isolated three full-length human genes that encode a novel subgroup of this receptor family. Recently, two of these receptors were identified as specific for alpha-melanocyte-stimulating hormone (alpha-MSH) and adrenocorticotropic hormone. We report the molecular cloning and pharmacologic characterization of a third member of this subgroup. The gene for this receptor encodes a protein of 361 amino acids in length. Its pharmacology characterizes it as an MSH receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. By Northern blot hybridization and polymerase chain reaction, it is expressed in brain, placental, and gut tissues but not in melanoma cells or in the adrenal gland. These findings may yield insight into the physiology of peptides derived from pro-opiomelanocortin post-translational processing.     

Modeling of silicon diffusion in gallium arsenide

A model is developed and a study is performed for amphoteric diffusion of silicon in gallium arsenide. A comparison of predictions with experimental data indicated adequacy of the devised model and high efficiency of the numerical method for solving the diffusion equation.Belorussian State University, Minsk. Minsk Radio Engineering Institute. Translated from Inzhenerno-Fizicheskii Zhurnal, Vol. 65, No. 5, pp. 567–572, November, 1993.     

Problems of heat/mass transfer and structure formation in easily deformable natural disperse systems

The results of studies of the processes of structure formation and moisture transfer in shaped organogenous materials are presented Principles have been formulated for selecting and using SAS and HMS for desired variation of moisture transfer and migration of ions in natural disperse systems. The results of experimental and theoretical investigations of heat/mass transfer and structure formation in freezing organogenous systems are given.Institute for Problems of Use of Natural Resources and Ecology, Academy of Sciences of Belarus, Minsk. Translated from Inzhenerno-Fizicheskii Zhurnal, Vol. 64, No. 6, pp. 752–762, June, 1992.     

Enhanced grid scheme for one-dimensional integro-differentialVolterra equation in the time domain

An enhanced numerical method for solving a one-dimensional (1-D) integro-differential Volterra equation for time- and spatially varying dispersive dielectric media is proposed. The scheme is based on spatial-time discretization (marching scheme) with an enhanced Courant stability condition. The algorithm performs refinement of the results by a prediction-correction scheme and imposes restrictions on neither the signal shape and duration nor on the temporal behavior of the medium and is therefore generic. Results show good correlation with existing theoretical solutions and considerable improvement in precision over previous techniques. The influence of electromagnetic transients in the lossless dielectric layer on reflection and transmission coefficients is investigated     

Mesh‐independent p‐orthotropic enrichment using the generalized finite element method

This paper is aimed at presenting a simple yet effective procedure to implement a mesh‐independent p‐orthotropic enrichment in the generalized finite element method. The procedure is based on the observation that shape functions used in the GFEM can be constructed from polynomials defined in any co‐ordinate system regardless of the underlying mesh or type of element used. Numerical examples where the solution possesses boundary or internal layers are solved on coarse tetrahedral meshes with isotropic and the proposed p‐orthotropic enrichment. Copyright © 2002 John Wiley & Sons, Ltd.