Effects of microelements on soil nematode assemblages seven years after contaminating an agricultural field

Long-term effects of Cd, Cr, Cu, Se and Zn were studied 7 years after artificially contaminating plots of an agricultural field on a calcareous chernozem soil. Effects of three to four different contamination levels (originally 10, 30, 90 and 270 mg kg⁻¹) were studied. Nematode density was significantly reduced by 90 and 270 mg kg⁻¹ Se as well as by 270 mg kg⁻¹ Cr, while 90 and 270 mg kg⁻¹ Se also reduced nematode generic richness. Maturity Index values (calculated for c-p 2–5 nematodes) consistently decreased with increasing Cr and Se concentration and to a lesser extent in Zn plots as well. Structure Index showed decreasing trends in increasing Cr, Se and (to a lesser extent) in Zn treatments, while in Cd it shows a moderate increase. Distribution of c-p groups was negatively affected by the increasing Cr and Se concentration, while in Zn plots, this decrease was not significant. Response of feeding groups to pollutions was similar to other parameters: Cr and Se caused significant changes toward the loss of variability. The proportion of the most sensitive omnivorous and predatory nematodes decreased clearly as a consequence of Cr and Se treatments. Zn pollution also resulted in a slight decrease in this group, while Cd caused an increase. Nematode diversity profiles showed a significant decrease in the plots of increased Cr and Se concentrations, while increased concentrations of Cu and Zn resulted in ambiguous effects. Besides providing evidence on the harmful effects of Cr and Se on a soil nematode assemblage, our results suggest that simultaneous analysis of Maturity Index, Structure Index and diversity profiles provide a promising tool in nematological indication of soil pollution.     

Factors influencing lake recovery from eutrophication--the case of basin 1 of Lake Balaton

Lake Balaton is a large, shallow, and calcareous lake that was subject to a rapid eutrophication during the 1970s. Management measures taken from the mid-1980s decreased the phosphorus load to the lake from 0.5 to 0.3 g P m-2 yr-1. Using long-term load and water quality data, we analyse the response of the formerly hypertrophic Basin 1 of the lake by the means of simple empirical models. Several factors that are commonly neglected during studies of lake recovery modified the apparent settling velocity of total P and consequently, the biomass of the phytoplankton. These factors included the loads of calcium and suspended solids, the loading ratio of the dissolved to particulate phosphorus, and blooming of the dominant cyanobacterium, Cylindrospermopsis raciborskii. Due to the rapid immobilisation of the mobile phosphorus in the surface sediments, moderate reduction (45-50%) in the external load resulted in a surprisingly fast and significant improvement of the water quality in the hypertrophic southwestern basins of the lake.     

Mild and neutral deprotections catalyzed by cerium(IV) ammonium nitrate

The development of a novel, chemoselective, and catalytic deprotection methodology that proceeds under mild and neutral conditions is described, and its mechanism of action is analyzed in some detail. The scope, limitations, and advantages of this protocol are discussed. Selected applications in synthesis are also highlighted.     

Comprehensive support for nuclear decommissioning based on 3D simulation and advanced user interface technologies

There is an increasing international focus on the need to optimise decommissioning strategies, driven by the anticipation of high costs and major effort for the decommissioning of nuclear facilities in the coming decades. The goals are to control and mitigate costs and negative impacts on workers, the general public, and the environment. The methods presently employed for many decommissioning tasks do not apply the latest advancements of science and technology. Therefore, there is growing interest in research and development into the adoption of novel techniques for improving safety, reducing costs, and increasing transparency.

This paper provides a comprehensive overview of the authors’ results from investigating how current and emerging technologies can be applied to enhance the international decommissioning strategy, focussing in particular on three-dimensional simulation, virtual reality, advanced user interfaces, mobile and wearable devices, and geographical information systems. Our results demonstrate that emerging technologies have great potential for supporting adoption of new instrumentation, improving data and knowledge management, optimising project plans, briefing and training field operators, and for communication, surveillance, and education in general.     

The Behavior of Matrix Metalloproteinases and Their Inhibitors in Colorectal Cancer

Matrix metalloproteinases (MMPs) play an important role in the degradation of extracellular matrix components crucial for tumor growth, invasion and metastasis. MMPs are controlled by natural inhibitors called tissue inhibitors of metalloproteinases (TIMPs). We and others have demonstrated that MMPs and TIMPs are especially important in the process of tumor invasion, progression and the metastasis of colorectal cancer (CRC). It has been proposed that MMPs and TIMPs might play a part not only in tumor invasion and initiation of metastasis but also in carcinogenesis from colorectal adenomas. Several recent studies demonstrated that high preoperative serum or plasma MMP-2, MMP-9 and TIMP-1 antigen levels are strong predictive factors for poor prognosis in patients with CRC and their determination might be useful for identification of patients with higher risk for cancer recurrence. MMP-9 and TIMP-1 have significant potential tumor marker impact in CRC. Their diagnostic sensitivity is consistently higher than those of conventional biomarkers. The pharmacological targeting of CRC by the development of a new generation of selective inhibitors of MMPs, that is highly specific for certain MMPs, is a promising and challenging area for the future.     

VBR Video Source Characterization and a Practical Hierarchical Model

There are many ways to build up traffic models for VBR video sources. A frequently applied methodology is to use mathematical analysis based on realistic assumptions to set up a source model that generates traffic according to a stochastic process. In this case, the critical issue is the validation of the synthetic trace by comparing statistics to results obtained from measurements on the real source. In this paper, we choose a different and more practical approach to model the behavior of the real traffic source. Our model building philosophy is that we analyze and understand what happens with the video information on its way from the ingress to the multimedia terminal to the egress of the network card. Throughout this journey the information is processed by several mechanisms and we build an empirical model step by step based on our measurement-based observations. Besides understanding the traffic generation procedure, statistical analysis of VBR traffic traces captured from a number of video sequences was also carried out in several scenarios. Using the knowledge of encoding, encapsulation and scheduling processes and results of the trace analysis, a hierarchical source model is set up for modeling the multimedia terminal. Thereby our model imitates the generation of video frames and the inner working of each level of protocol hierarchy and tries to reproduce the complex behavior of the real source. We use the leaky bucket analysis for verification of the model in order to capture directly the behavior of the traffic in a queue.     

DUckCov: a Dynamic Undocking-Based Virtual Screening Protocol for Covalent Binders

Thanks to recent guidelines, the design of safe and effective covalent drugs has gained significant interest. Other than targeting non-conserved nucleophilic residues, optimizing the noncovalent binding framework is important to improve potency and selectivity of covalent binders toward the desired target. Significant efforts have been made in extending the computational toolkits to include a covalent mechanism of protein targeting, like in the development of covalent docking methods for binding mode prediction. To highlight the value of the noncovalent complex in the covalent binding process, here we describe a new protocol using tethered and constrained docking in combination with Dynamic Undocking (DUck) as a tool to privilege strong protein binders for the identification of novel covalent inhibitors. At the end of the protocol, dedicated covalent docking methods were used to rank and select the virtual hits based on the predicted binding mode. By validating the method on JAK3 and KRas, we demonstrate how this fast iterative protocol can be applied to explore a wide chemical space and identify potent targeted covalent inhibitors.     

An analytical method to design annular microfilaments with uniform temperature

Microsystem Technologies - Due to their complex electro-thermal characteristics microhotplates used in environmental gas sensors require careful design to exhibit uniform temperature and low power...     

2-(E)-nonen-1-ol: Male attractant for chafersAnomala vitis Fabr. andA. dubia Scop. (Coleoptera: Scarabaeidae)

Traps baited with 2-(E)-nonen-1-ol alone or in combination with other compounds caught large numbers of males of both the vine chafer,Anomala vitis Fabr. and the margined vine chafer,A. dubia Scop. (Coleoptera: Scarabaeidae), vineyard and orchard pests. In a dosage test, the largest numbers were caught by traps baited with 10 mg of 2-(E)-nonen-1-ol, which was the highest dosage tested. This is the first report on male attractants for chafer species occurring in Europe.The present paper is dedicated to the memory of our coauthor, friend and colleague Mátyás Lesznyák who died a premature and tragic death in late 1993.     

Nitrogen containing compounds

Bridge-head nitrogen-containing compounds, (1,4-diaza-bicyclo-[2.2.2]-octane, 1-azabicyclo-[2.2.2]-octane, 1,5-diaza-bicyclo-[5.4.0]-undec-5-ene and l-azabicyclo-[2.2.2]-octane-3-one), successfully catalyze the ethoxylation of dodecyl alcohol. The catalytic activity of any of the first two compounds was four to five times higher than that of an open-chain, symmetrical trialkylamine of similar basicity. The molar mass distribution of the ethoxylated dodecyl alcohol derivatives was of the Weibull-Nycander-Gold type. No Weibull-Törnquist effect could be detected, however, unlike the case realized in ethoxylated systems gained in the presence of trialkylamines. No change in the distribution constant (calculated according to Natta and Mantica) could be observed in the course of these ethoxylation reactions.