Guaranteed recall of all training pairs for bidirectionalassociative memory

Necessary and sufficient conditions are derived for the weights of a generalized correlation matrix of a bidirectional associative memory (BAM) which guarantee the recall of all training pairs. A linear programming/multiple training (LP/MT) method that determines weights which satisfy the conditions when a solution is feasible is presented. The sequential multiple training (SMT) method is shown to yield integers for the weights, which are multiplicities of the training pairs. Computer simulation results, including capacity comparisons of BAM, LP/MT BAM, and SMT BAM, are presented.     

Coolers Based on Solid Sorbents

A cooler based on solid sorbents, in which an activated carbon fiber (pure) and an activated carbon fiber impregnated with CaCl₂ are used, has been designed. Results of an experimental investigation of the time dependence of the change in the heat flux are presented.     

Long-Term Spinal Ventral Root Reimplantation,but not Bone Marrow Mononuclear Cell Treatment,Positively Influences Ultrastructural Synapse Recovery and Motor Axonal Regrowth

We recently proposed a new surgical approach to treat ventral root avulsion, resulting in motoneuron protection. The present work combined such a surgical approach with bone marrow mononuclear cells (MC) therapy. Therefore, MC were added to the site of reimplantation. Female Lewis rats (seven weeks old) were subjected to unilateral ventral root avulsion (VRA) at L4, L5 and L6 levels and divided into the following groups (n = 5 for each group): Avulsion, sealant reimplanted roots and sealant reimplanted roots plus MC. After four weeks and 12 weeks post-surgery, the lumbar intumescences were processed by transmission electron microscopy, to analyze synaptic inputs to the repaired α motoneurons. Also, the ipsi and contralateral sciatic nerves were processed for axon counting and morphometry. The ultrastructural results indicated a significant preservation of inhibitory pre-synaptic boutons in the groups repaired with sealant alone and associated with MC therapy. Moreover, the average number of axons was higher in treated groups when compared to avulsion only. Complementary to the fiber counting, the morphometric analysis of axonal diameter and “g” ratio demonstrated that root reimplantation improved the motor component recovery. In conclusion, the data herein demonstrate that root reimplantation at the lesion site may be considered a therapeutic approach, following proximal lesions in the interface of central nervous system (CNS) and peripheral nervous system (PNS), and that MC therapy does not further improve the regenerative recovery, up to 12 weeks post lesion.     

Developing an Irreversible Inhibitor of Human DDAH‐1, an Enzyme Upregulated in Melanoma

Inhibitors of the human enzyme dimethylarginine dimethylaminohydrolase‐1 (DDAH‐1) can raise endogenous levels of asymmetric dimethylarginine (ADMA) and lead to a subsequent inhibition of nitric oxide synthesis. In this study, N⁵‐(1‐imino‐2‐chloroethyl)‐L ‐ornithine (Cl‐NIO) is shown to be a potent time‐ and concentration‐dependent inhibitor of purified human DDAH‐1 (K_I=1.3±0.6 μM ; k_inact=0.34±0.07 min^?1), with >500‐fold selectivity against two arginine‐handling enzymes in the same pathway. An activity probe is used to measure the “in cell” IC₅₀ value (6.6±0.2 μM ) for Cl‐NIO inhibition of DDAH‐1 artificially expressed within cultured HEK293T cells. A screen of diverse melanoma cell lines reveals that a striking 50/64 (78 %) of melanoma lines tested showed increased levels of DDAH‐1 relative to normal melanocyte control lines. Treatment of the melanoma A375 cell line with Cl‐NIO shows a subsequent decrease in cellular nitric oxide production. Cl‐NIO is a promising tool for the study of methylarginine‐mediated nitric oxide control and a potential therapeutic lead compound for other indications with elevated nitric oxide production, such as septic shock and idiopathic pulmonary fibrosis.     

Effect of colloidal silica on the mechanical properties of fiber–cement reinforced with cellulosic fibers

The effect of colloidal silica on the hydration reaction of the Portland cement system and its effect on the resulting mechanical properties are not completely understood. Silica nanoparticles can affect the behavior and performance of fiber–cement, such as the calcium–silicate–hydrate gel of the matrix and the fiber–matrix interface bonding. The main objective of this study is to evaluate the effects of various contents of colloidal silica (0, 1.5, 3, 5, and 10 % w/w) on the microstructure and mechanical performance of cement composites reinforced with cellulosic pulp. Fiber–cement composites with unbleached eucalyptus Kraft pulp as the micro-fiber reinforcement were produced by the slurry dewatering technique followed by pressing. The average values of the modulus of rupture of the fiber–cement decreased with increasing colloidal silica content. However, the pullout of the fibers increased significantly in the fiber–cement composites with additions between 3 and 10 % w/w of colloidal silica suspension, as indicated in the scanning electron microscopy images and by the improvement in the energy of fracture values.     

A physical perspective of the element‐based finite volume method and FEM‐Galerkin methods within the framework of the space of finite elements

The literature shows an increasing number of works focused on investigating the behaviour of methods that uses concepts of control volumes in the solution of structural problems. In recent years, new approaches using unstructured meshes have been proposed, most of which addressing new applications and, to a lesser extent, the underling physical perspective. This paper presents a unified approach to the element‐based finite volume method and FEM‐Galerkin within the framework of the finite element space. Numerical examples highlight some accuracy issues associated with the element‐based finite volume method developed in this work. Copyright © 2014 John Wiley & Sons, Ltd.     

Preparing of pellets by extrusion/spheronization using different types of equipment and process conditions

Introduction: The focus of this work was to produce matrix pellets made by extrusion/ spheronization using two types of equipment. The aim was to accomplish the laboratory-scale I process that has been already optimized and accepted with another type of equipment (laboratory-scale II).

Methods: A matrix pellet formulation consisting of MCC, Eudragit NE 30D and diclofenac sodium was used in the two types of equipment. Physico-chemical parameters and the dissolution profiles of the pellets in phosphate buffer pH 6.8 were compared.

Results: Pellets from both processes were similar in shape and tensile strength. They differed in particle size and dissolution profile. This may be contributed to different spheronization conditions.     

The Vortex Path Model Analysis of the Field Angle Dependence of the Critical Current Density in Nanocomposite YBa2Cu3 O 7−x – BaZrO3 Films Obtained by Low Fluorine Chemical Solution Deposition

In the present paper, we analyze the role of in situ grown BaZrO₃ (BZO) inclusions in YBa₂Cu₃O_7?x (YBCO) thin films prepared by chemical solution deposition using a low fluorine coating solution, on the field angle dependence of the critical current density, J _c (??), data using the vortex path model. In order to form a coherent picture on the BZO doping influence on the pinning properties of the YBCO matrix, detailed structural analyses performed by X-ray diffraction techniques and microstructural evaluation by transmission electron microscopy are also presented. The evaluation of different contributions to the overall, J _c , permitted us to prove the effectiveness of the BZO inclusions acting as isotropic pinning centers, reflected in a uniform component of high relative value with respect to other components. For the studied 10 mol % BZO doping concentration, a threefold increase in the critical current density, J _c , of the YBCO host is measured, in self-field at 77 K, corresponding to a value of J _c =2.9MA/cm², whereas a factor 10 is measured at 1 T (J _c =0.35 MA/cm²).