全文获取类型
收费全文 | 529篇 |
免费 | 36篇 |
专业分类
电工技术 | 1篇 |
化学工业 | 222篇 |
金属工艺 | 12篇 |
机械仪表 | 6篇 |
建筑科学 | 12篇 |
矿业工程 | 1篇 |
能源动力 | 12篇 |
轻工业 | 152篇 |
水利工程 | 2篇 |
石油天然气 | 3篇 |
无线电 | 11篇 |
一般工业技术 | 74篇 |
冶金工业 | 12篇 |
自动化技术 | 45篇 |
出版年
2024年 | 3篇 |
2023年 | 6篇 |
2022年 | 50篇 |
2021年 | 52篇 |
2020年 | 25篇 |
2019年 | 22篇 |
2018年 | 23篇 |
2017年 | 21篇 |
2016年 | 26篇 |
2015年 | 16篇 |
2014年 | 22篇 |
2013年 | 43篇 |
2012年 | 48篇 |
2011年 | 44篇 |
2010年 | 30篇 |
2009年 | 28篇 |
2008年 | 20篇 |
2007年 | 13篇 |
2006年 | 17篇 |
2005年 | 5篇 |
2004年 | 4篇 |
2003年 | 13篇 |
2002年 | 6篇 |
2001年 | 4篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1994年 | 1篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 3篇 |
1971年 | 1篇 |
排序方式: 共有565条查询结果,搜索用时 0 毫秒
501.
The glass transition temperature (Tg) advancement and the chemoviscosity development under isothermal conditions have been investigated for four epoxy/amine systems, including commercial RTM6 and F934 resins. Differential scanning calorimetry (DSC) was the thermoanalytical technique used to determine the Tg advancement and rheometry the technique for the determination of the chemoviscosity profiles of these resin systems. The complex cure kinetics were correlated to the Tg advancement via an one‐to‐one relationship using Di Benedetto's formula. It was revealed that the three‐dimensional network formation follows a single activated mechanism independent of whether the cure kinetics follow a single or several activation mechanisms. The viscosity profiles showed the typical characteristics of epoxy/amine cure. A modified version of the Williams‐Landel‐Ferry equation (WLF) was adequate to model the viscosity profiles of all the resin systems, in the temperature range 130 to 170°C, with a very good degree of accuracy. The parameters of the WLF equation were found to vary in a systematic manner with cure temperature. Further correlation between Tg and viscosity showed that gelation, defined as the point where viscosity reaches 104 Pas, occurs at a unique Tg value for each resin system, which is independent of the cure conditions. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 77: 2178–2188, 2000 相似文献
502.
503.
Abdulbaset Zidane Shirif Sanja Kova
evi Jelena Brklja
i Ana Teofilovi Ivana Elakovi Ana Djordjevic Gordana Mati 《International journal of molecular sciences》2021,22(13)
The modern lifestyle brings both excessive fructose consumption and daily exposure to stress which could lead to metabolic disturbances and type 2 diabetes. Muscles are important points of glucose and lipid metabolism, with a crucial role in the maintenance of systemic energy homeostasis. We investigated whether 9-week fructose-enriched diet, with and without exposure to 4-week unpredictable stress, disturbs insulin signaling in the skeletal muscle of male rats and evaluated potential contributory roles of muscle lipid metabolism, glucocorticoid signaling and inflammation. The combination of fructose-enriched diet and stress increased peroxisome proliferator-activated receptors-α and -δ and stimulated lipid uptake, lipolysis and β-oxidation in the muscle of fructose-fed stressed rats. Combination of treatment also decreased systemic insulin sensitivity judged by lower R-QUICKI, and lowered muscle protein content and stimulatory phosphorylations of insulin receptor supstrate-1 and Akt, as well as the level of 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor. At the same time, increased levels of protein tyrosine phosphatase-1B, nuclear factor-κB, tumor necrosis factor-α, were observed in the muscle of fructose-fed stressed rats. Based on these results, we propose that decreased glucocorticoid signaling in the skeletal muscle can make a setting for lipid-induced inflammation and the development of insulin resistance in fructose-fed stressed rats. 相似文献
504.
The present study investigates the influence of partial cement substitution with biomass ash on the corrosion behaviour of steel embedded in the mortar. To evaluate this influence, corrosion parameters of steel in mortar exposed to tap water and 3.5 wt% NaCl solution were monitored over a period of 50 days. The electrochemical cell consisted of a steel plate as a working electrode, covered with a layer of mortar that was exposed to the testing solution. Open-circuit potential and linear polarisation were used to monitor changes in corrosion behaviour, whereas electrical impedance spectroscopy was used to evaluate the conductivity of the matrix. Additional to corrosion parameters, the chloride migration coefficient was tested after 28 days. On the basis of the results, it was observed that mortars with biomass ash provide equal or better protection for embedded steel, compared with the reference mortar. Mortars that performed slightly better than the reference mortar and other mortars were prepared with ashes with a higher amount of pozzolanic oxides. 相似文献
505.
David O Warner Robert C Colligan Richard D Hurt Ivana T Croghan Darrell R Schroeder 《Nicotine & tobacco research》2007,9(11):1207-1212
Some clinicians and patients believe that cough and sputum production may transiently increase over the first weeks after smoking cessation and may in fact represent a barrier to successful quitting. The present study described changes in cough after an attempt to quit smoking cigarettes and determined patients' perceptions of how changes in cough affected their ability to maintain abstinence from smoking. Daily smokers already recruited for ongoing outpatient clinical trials of pharmacological aids to quit cigarette smoking were invited to complete self-report questionnaires about their cough for up to 6 weeks after their target quit date (TQD). Of the 176 subjects invited to participate, 112 completed the first assessment after the TQD. Of these, a total of 45 subjects maintained at least 1week of smoking abstinence at some point in the 6-week period (confirmed by carbon monoxide measurements). Two self-report measures found that cough declined steadily in abstinent smokers but was constant in a comparator group of continuing smokers (n = 36). For the 94 subjects who reported smoking at least one cigarette following the TQD, few reported that changes in cough affected their abstinence attempt. For three items asking about this area, the upper 95% confidence interval was no more than 10% for agreement that changes in cough posed any barrier to abstinence. We conclude that an initial increase in cough is unlikely to occur among relatively healthy smokers who stop smoking and that changes in cough do not represent a barrier to maintaining abstinence for most smokers. 相似文献
506.
Hrvoje Punda Snjezana Mardesic Natalija Filipovic Ivona Kosovic Benjamin Benzon Marin Ogorevc Ivana Bocina Kresimir Kolic Katarina Vukojevic Mirna Saraga-Babic 《International journal of molecular sciences》2021,22(14)
The expression of 5-HT (serotonin) receptors (sr) was analyzed in the spinal cord and ganglia of 15 human conceptuses (5–10-weeks), and in the 9-week fetus with spina bifida. We used immunohistochemical method to detect sr-positive, apoptotic (caspase-3) and proliferating (Ki-67) cells, double immunofluorescence for co-localization with protein gene peptide (pgp) 9.5 and GFAP, as well as semiquantification and statistical measurements. Following the neurulation process, moderate (sr1 and sr2) and mild (sr3) expression characterized neuroblasts in the spinal cord and ganglia. During further development, sr1 expression gradually increased in the motoneurons, autonomic and sensory neurons, while sr2 and sr3 increased strongly in floor and roof plates. In the ganglia, sr3 expression increased during limited developmental period, while sr1 and sr2 increased throughout the investigated period. Co-expression of sr/pgp 9.5 characterized developing neurons, while sr/GFAP co-localized in the roof plate. In the spinal cord and ganglia of malformed fetus, weaker sr1 and sr2 and stronger sr3 expression accompanied morphological abnormalities. Anomalous roof plate morphology showed an excess of apoptotic and proliferating cells and increased sr3 expression. Our results indicate a human-species specific sr expression pattern, and the importance of sr1 in neuronal differentiation, and sr2 and sr3 in the control of the roof plate morphogenesis in normal and disturbed development. 相似文献
507.
Nina Krei Marina Prilin Dunja Vlahovi Petar Kostei Ivana Ljolje Dragan Brni Nenad Turk Andrija Musulin Boris Habrun 《International journal of molecular sciences》2021,22(14)
The influence of cultivation on the expression pattern of canine adipose-derived mesenchymal stem cells (cAD-MSCs) surface markers, contributing to, among others, the promotion of growth, proliferation, differentiation and immunomodulatory mechanisms of an excellent therapeutic, is still unknown. To fill the gap, we investigated CD90, CD44, CD73, CD29, CD271, CD105, CD45 and CD14 patterns of expression at the protein level with flow cytometry and mRNA level using a real-time polymerase chain reaction array. Gentle variations of expression occurred during cultivation, along with increased CD90, CD44 and CD29 expression, low and decreasing CD271 and CD73 expression and a decrease of initially high CD105. As expected, CD45 and CD14 were not expressed by cAD-MSCs. Interestingly, we discovered a significant decrease of CD73 expression, compared to early (P1–P3) to late (P4–P6) passages, although the CD73 gene expression was found to be stable. The percentage of positive cells was found to be higher for all positive markers up to P4. As CD73′s one important feature is a modulation from a pro-inflammatory environment to an anti-inflammatory milieu, the expression of CD73 in our conditions indicate the need to consider the time cells spend in vitro before being transplanted into patients, since it could impact their favourable therapeutical properties. 相似文献
508.
Ivana LulaFrederico B. De Sousa Ângelo M.L. DenadaiGuilherme Ferreira de Lima Hélio Anderson DuarteThiago R. dos Mares Guia Adelaide Faljoni-AlarioMarcelo M. Santoro Antônio C.M. de CamargoRobson A.S. dos Santos Rubén D. Sinisterra 《Materials science & engineering. C, Materials for biological applications》2012,32(2):244-253
Herein, we demonstrate the physical and chemical characterizations of the supramolecular complex formed between β-cyclodextrin (βCD) and bradykinin potentiating nonapeptide (BPP9a), an endogenous toxin found in Bothrops jararaca. Circular dichroism results indicate a conformational change in the BPP9a secondary structure upon its complexation with βCD. Nuclear magnetic resonance results, mainly from NOESY experiments, and theoretical calculations showed a favorable interaction between the tryptophan residue of BPP9a and the βCD cavity. Thermodynamic inclusion parameters were investigated by isothermal titration calorimetry, demonstrating that βCD/BPP9a complex formation is an exothermic process that results in a reduction in entropy. Additionally, in vitro degradation study of BPP9a against trypsin (37 °C, pH 7.2) showed higher stability of peptide in presence of βCD. This βCD/BPP9a complex, which presents new chemical properties arising from the peptide inclusion process, may be useful as an antihypertensive drug in oral pharmaceutical formulations. 相似文献
509.
Nina Bilandžić Maja Đokić Marija Sedak Božica Solomun Ivana Varenina Zorka Knežević Miroslav Benić 《Food chemistry》2011
A total of 157 raw milk samples were collected from tankers arriving at processing facilities from rural areas in northern and southern regions of Croatia during 2009 and 2010. Concentrations of As, Cd, Cu, Hg and Pb in the samples were analysed by graphite furnace-atomic absorption spectroscopy. Mean Pb concentrations in northern and southern regions were 58.7 and 36.2 μg l−1, respectively, and both exceeded the maximum recommended level. Arsenic concentrations ranged from 1 to 283 μg l−1 in the southern and to 1019 μg l−1 in the northern regions. Mean Cd and Hg levels were: 1.76 and 1.59 in the northern and 3.4 and 7.1 μg l−1 in the southern region. Significantly higher Cd and Hg levels were observed in the southern than in the northern region (p < 0.001, both). Similar mean Cu levels were found in both regions: 931.9 in the north and 848.4 μg l−1 in the south. The results indicate that particular attention should be paid to Pb residues. In future studies, a greater number of milk samples and grass samples from pastures from different regions of Croatia should be controlled to confirm the absence of possible toxicological risks. 相似文献
510.
Valerio C. D. Soares Melquizedeque B. Alves Ernesto R. Souza Ivana O. Pinto Joel C. Rubim Carlos Kleber Z. Andrade Paulo A. Z. Suarez 《International journal of molecular sciences》2007,8(5):392-398
The combinations of 1-butyl-3-methylimidazolium chloride with NbCl5 yielded ionic mixtures with different melting point temperatures and acidity depending on the niobium molar fraction. The mixtures were characterized by thermal (DSC) and spectroscopic (FT-IR and 1H NMR) analysis. The Pechmann reactions of different phenols with ethylacetoacetate, producing coumarins, was used as model to evaluate the catalytic behavior of these mixtures as acid Lewis catalyst. These reactions were carried out using acidic mixtures of 60 mol%. 相似文献