On the mechanisms of adenosine induced pulmonary vasoconstriction in rats

The effect of adenosine on pulmonary vessels was studied in isolated perfused rat lungs. Drugs were administered intra-arterially in a fixed volume of 0.1 ml Krebs solution as bolus injections. Adenosine responses were obtained before and 10 min after drug injections. When applied in logarithmically increasing doses (1-100 micrograms/ml), adenosine caused dose-dependent increases in pulmonary perfusion pressure (e.g. pulmonary vasoconstriction) which were readily reversible. Challenging adenosine with quinidine, dihydroergocristine and cyproheptadine (2 micrograms/ml each) did not significantly alter adenosine responses. Pretreatment of lungs with 0.5 mM theophylline, 10 micrograms/ml indomethacin, 30 micrograms/ml tebokan (a PAF antagonist) or 1 microgram/ml methylene blue for 10 min, however, antagonized the vasoconstrictor effect of the drug significantly. From these experiments, it was concluded that the mechanisms underlying the pulmonary vasoconstrictor action of adenosine are complex, and that both types of purinoceptors, prostaglandins, PAF and other vascular endothelial hormones might be involved.     

Crossing the planes at high speed. Signal integrity issues at splitground and power planes

This article discusses a specific design situation that represents quite a broad class of problems in the study of signal integrity. The article focuses on the effects on high-speed signals that need to cross split ground planes and split power planes that act as signal references or partial references. Such configurations are frequently needed in the layout of printed circuit boards (PCBs), multichip modules (MCMs), and even single-chip modules. Examples of split ground and power planes are discussed first. The conventional effective inductance model is described briefly, and an accurate and efficient transmission line model is then discussed in detail. Examples of modeling and design trade-offs are also presented     

Electron traps created in gate oxides by Fowler–Nordheim injections

Two types of electron traps, donor-like and acceptor-like, are created in the gate oxide of metal-oxide-semiconductor capacitors by Fowler–Nordheim electron injections. Electrical properties (areal density, capture cross-section, centroid) of each type of trap are determined by using the avalanche electron injection method and by combining capacitance–voltage and current–voltage measurements. These properties are measured with regard to the Fowler–Nordheim fluence up to breakdown and for both injection modes (electrons injected either from the gate or from the substrate of capacitors).     

Physical and chemical characterization of thermosoftened bases for molten filled hard gelatin capsule formulations

Dynafill, Dynasan-114, Lutrol-F68, PEG-10000 and PEG-20000 have been examined as potential bases for the preparation of fusion formed solid dispersions for molten filling into hard gelatin capsules. Investigations included, an examination of thermal effects on crystal structure by DSC and XRD, a theological study to evaluate capsule filling characteristics, dissolution studies on drug/base formulations, chemical analysis for free fatty acid impurities in Dynafill and Dynasan-114, and detailed studies on selected drug/base formulations. PEG-20000 and Dynasan-114 were not examined in detail, after preliminary investigations had shown high viscosity and poor filling characteristics for PEG-20000 and poor dissolution characteristics for Dynasan-114. Dynafill provided good release profiles when formulated with a variety of model drugs (Acetohexamide, Ibuprofen, Indomethacin, Quinidine sulphate and Theophylline). Results from hot stage photomicrography supported by DSC and XRD were used to construct a phase diagram of the Ibuprofen/Lutrol-F68 system. The evidence from the phase diagram indicated the formulation of a simple eutectic system with no solid solubility and a eutectic composition at approximately 35% w/w Ibuprofen.     

Vibrational control of linear time lag systems with arbitrarilylarge but bounded delays

It is shown that vibrational stabilization can be effective for linear systems with large bounded delays. Theorems are given that define the procedures for the search of the stabilizing vibrations. Robust oscillatory stabilization insensitive to the delay size is also shown to take place for some classes of systems