Stacked Gated Recurrent Unit Classifier with CT Images for Liver Cancer Classification

Liver cancer is one of the major diseases with increased mortality in recent years, across the globe. Manual detection of liver cancer is a tedious and laborious task due to which Computer Aided Diagnosis (CAD) models have been developed to detect the presence of liver cancer accurately and classify its stages. Besides, liver cancer segmentation outcome, using medical images, is employed in the assessment of tumor volume, further treatment plans, and response monitoring. Hence, there is a need exists to develop automated tools for liver cancer detection in a precise manner. With this motivation, the current study introduces an Intelligent Artificial Intelligence with Equilibrium Optimizer based Liver cancer Classification (IAIEO-LCC) model. The proposed IAIEO-LCC technique initially performs Median Filtering (MF)-based pre-processing and data augmentation process. Besides, Kapur’s entropy-based segmentation technique is used to identify the affected regions in liver. Moreover, VGG-19 based feature extractor and Equilibrium Optimizer (EO)-based hyperparameter tuning processes are also involved to derive the feature vectors. At last, Stacked Gated Recurrent Unit (SGRU) classifier is exploited to detect and classify the liver cancer effectively. In order to demonstrate the superiority of the proposed IAIEO-LCC technique in terms of performance, a wide range of simulations was conducted and the results were inspected under different measures. The comparison study results infer that the proposed IAIEO-LCC technique achieved an improved accuracy of 98.52%.     

Political Optimizer with Deep Learning-Enabled Tongue Color Image Analysis Model

Biomedical image processing is widely utilized for disease detection and classification of biomedical images. Tongue color image analysis is an effective and non-invasive tool for carrying out secondary detection at anytime and anywhere. For removing the qualitative aspect, tongue images are quantitatively inspected, proposing a novel disease classification model in an automated way is preferable. This article introduces a novel political optimizer with deep learning enabled tongue color image analysis (PODL-TCIA) technique. The presented PODL-TCIA model purposes to detect the occurrence of the disease by examining the color of the tongue. To attain this, the PODL-TCIA model initially performs image pre-processing to enhance medical image quality. Followed by, Inception with ResNet-v2 model is employed for feature extraction. Besides, political optimizer (PO) with twin support vector machine (TSVM) model is exploited for image classification process, shows the novelty of the work. The design of PO algorithm assists in the optimal parameter selection of the TSVM model. For ensuring the enhanced outcomes of the PODL-TCIA model, a wide-ranging experimental analysis was applied and the outcomes reported the betterment of the PODL-TCIA model over the recent approaches.     

Copper/copper oxide nanoparticles synthesis using Stachys lavandulifolia and its antibacterial activity

Nanoparticles of copper/cuprous oxide (Cu/Cu₂ O) were successfully synthesised by a green chemistry route. The synthesis process was carried out using an extract of Stachys lavandulifolia as both reducing and capping agents with a facile procedure. The nanoparticles were characterised by different techniques including X‐ray diffraction, indicating that the synthesised sample comprised both copper and cuprous oxide entity. The nanoparticles had a mean size of 80 nm and represented an impressive bactericidal effect on Pseudomonas aeruginosa.Inspec keywords: copper, copper compounds, nanoparticles, nanofabrication, nanomedicine, antibacterial activity, X‐ray diffractionOther keywords: nanoparticles synthesis, Stachys lavandulifolia, antibacterial activity, green chemistry route, reducing agents, capping agents, X‐ray diffraction, bactericidal effect, Pseudomonas aeruginosa, Cu‐Cu₂ O     

A study of the impact of the willingness-to-learn of CAD novice users on their competence development

The notion that ‘attitude drives behavior’ manifests itself in a variety of ways in educational and occupational settings. As applied to CAD competence development, industrial training of novice CAD users on their way to becoming competent CAD users consume a lot of corporate resources. This paper is the third paper in the line of research that attempts to answer the question having to do with what it takes to make a competent CAD user. Specifically, we examine the CAD-specific factors revolving around the trainees’ willingness-to-learn CAD.These factors are analyzed in two stages. At the start of the training, trainees’ initial attitude towards CAD is established by means of a short questionnaire. Afterwards, throughout the training, trainees’ behavior (online and offline practice) is gauged and, in turn, a relation is established to illustrate how this practice leads to the development of CAD-specific skills. For this purpose, another short questionnaire was utilized. Strong correlations were established relating the trainees’ CAD-specific behavior with the CAD-specific outcomes of learning CAD syntax.Furthermore, and in order to assess the quality of the trainees’ learning of CAD, overall competence was monitored throughout the study via performance measures that describe the time it took the trainees to build test models (speed), which reflects upon the ability to learn the syntax of the CAD tool (declarative knowledge). The sophistication of the models is also used as another measure. Correlating the trainees’ character attributes with these assessed measures, it was found that the stronger is the trainees’ will to learn CAD, the stronger is the likelihood to learn faster. Perhaps more importantly, trainees with initial favorable attitude toward CAD were shown to develop increasingly positive behavior that manifested through additional practice and other forms of visible effort.     

Analyzing CAD competence with univariate and multivariate learning curve models

Understanding how learning occurs, and what improves or impedes the learning process is of importance to academicians and practitioners; however, empirical research on validating learning curves is sparse. This paper contributes to this line of research by collecting and analyzing CAD (computer-aided design) procedural and cognitive performance data for novice trainees during 16-weeks of training. The declarative performance is measured by time, and the procedural performance by the number of features used to construct a design part. These data were analyzed using declarative or procedural performance separately as predictors (univariate), or a combination of declarative or procedural predictors (multivariate). Furthermore, a method to separate the declarative and procedural components from learning curve data is suggested.     

A theory of mode of action of azolylalkylquinolines as DNA binding agents using automated flexible ligand docking

Azolylalkylquinolines (AAQs) are a family of quinolines with varying degrees of cytotoxic activity (comparable or moderately superior to adriamycin in some cases) developed in the past decade in our group where their exact mode of action is still unclear. In this study the most probable DNA binding mode of AAQs was investigated employing a novel flexible ligand docking approach by using AutoDock 3.0. Forty-nine AAQs with known experimental inhibitory activity were docked onto d(CGCAAATTTGCG)(2), d(CGATCG)(2) and d(CGCG)(2) oligonucleotides retrieved from the Protein Data Bank (PDB IDs: 102D, 1D12 and 1D32, respectively) as the representatives of the three plausible models of interactions between chemotherapeutic agents and DNA (groove binding, groove binding plus intercalation and bisintercalation, respectively). Good correlation (r(2)=0.64) between calculated binding energies and experimental inhibitory activities was obtained using groove binding plus intercalation model for phenyl-azolylalkylquinoline (PAAQ) series. Our findings show that the most probable mode of action of PAAQs as DNA binding agents is via intercalation of quinolinic moiety between CG base pairs with linker chain and azole moiety binding to the minor groove.     

Variant versus invariant time to total forgetting: the learn–forget curve model revisited

Understanding and quantifying the learning–forgetting process helps predict the performance of an individual (or a group of individuals), estimate labor costs, bid on new and repeated orders, estimate costs of strikes, schedule production, develop training programs, set time standards, and improve work methods [IIE Trans. 29 (1997) 759]. Although there is agreement that the form of the learning curve is as presented by [J. Aeronaut. Sci. 3 (1936) 122], scientists and practitioners have not yet developed a full understanding of the behavior and factors affecting the forgetting process. The paucity of research on forgetting curves has been attributed to the practical difficulties involved in obtaining data concerning the level of forgetting as a function of time [IIE Transactions 21 (1989) 376]. The learn–forget curve model (LFCM) was shown to have many advantages over other theoretical models that capture the learning–forgetting relationship. However, the deficiency of the LFCM is in the assumption that the time for total forgetting is invariant of the experience gained prior to interruption. This paper attempts to correct this deficiency by incorporating the findings of [Int. J. Ind. Ergon. 10 (1992) 217] into the LFCM. Numerical examples are used to illustrate the behavior of the modified LFCM (MLFCM) and compare results to those of the LFCM.     

Fabrication and characterization of highly efficient three component CuBTC/graphene oxide/PSF membrane for gas separation application

Metal organic frameworks (MOFs) with marvelous properties have aroused enormous attention for different application especially gas adsorption and separation. In this regard, fabrication of MOF hybrids with carbon based materials is new strategy to upgrade MOF performance. In this study CuBTC (Copper benzene-1,3,5-tricarboxylic acid)/graphene oxide (GO) composite was synthesized and characterized by BET, SEM, TGA, XRD and FT-IR techniques. Then CuBTC and CuBTC/GO composite were incorporated into polysulfone (PSF) polymer to construct mixed matrix membranes (MMMs). The obtained membranes were characterized by SEM, TGA, XRD and tensile tests and their gas permeability was measured. The results were compared to those of CuBTC/PSF MMMs. It was revealed that CuBTC/GO composite as filler showed superior performance relative to CuBTC. For instance, 15 wt% loading of CuBTC/GO in PSF represented outstanding gas separation behavior while the same loading of CuBTC in PSF deteriorated performance of MMM. Well particle dispersion and favorable polymer-filler interaction were responsible for such observed difference. A high H₂/CH₄ and H₂/N₂ selectivity of 80.03 and 70.46 were recorded for CuBTC/GO in PSF (15 wt%) compared to 44.56 and 40.92 for CuBTC in PSF (15 wt%).