High-performance simulations of turbulent boundary layer flow using Intel Xeon Phi many-core processors

The Journal of Supercomputing - Direct numerical simulations (DNS) of turbulent flows have increasing importance because they not only provide fundamental understanding of turbulent flows but also...     

Neural network’s selection of color in UI design of social software

Neural Computing and Applications - In recent years, the design of social software UI has become a design research focus in the field of design. Color affects many factors in UI design. However,...     

The squash-and-stretch stylization for character motions

The squash-and-stretch describes the rigidity of the character. This effect is the most important technique in traditional cartoon animation. In this paper, we introduce a method that applies the squash-and-stretch effect to character motion. Our method exaggerates the motion by sequentially applying the spatial exaggeration technique and the temporal exaggeration technique. The spatial exaggeration technique globally deforms the pose in order to make the squashed or stretched pose by modeling it as a covariance matrix of joint positions. Then, the temporal exaggeration technique computes a time-warping function for each joint, and applies it to the position of the joint allowing the character to stretch its links appropriately. The motion stylized by our method is a sequence of squashed and stretched poses with stretching limbs. By performing a user survey, we prove that the motion created using our method is similar to that used in 2D cartoon animation and is funnier than the original motion for human observers who are familiar with 2D cartoon animation.     

Advanced partial encryption using watermarking and scrambling in MP3

In this paper, we propose an advanced partial encryption of watermarking and scrambling using the magnitude information of Modifed Discrete Cosine Transform (MDCT). In MPEG-1/Audio Layer III (MP3), the magnitude and phase information of modified discrete cosine transform (MDCT) coefficients is encrypted. The proposed method uses both watermarking and scrambling, and aims at protecting the contents against eavesdropping and moreover against illegal mass distribution after descrambled. Experimental results show that the proposed method can achieve higher security and less computational complexity by reusing the MDCT coefficients obtained in MP3.     

Performance of TZCD-MBOK watermarking scheme in T-DMB systems

Recently, watermarking based data transmission techniques using terrestrial digital TV signal have been proposed since they are also cost-free and can overcome the limitations of GPS. However, in the previous watermarking based methods, the detection accuracy is low and additional data rate is too low. Thus, we propose the throughput enhancement method by employing the TZCD-MBOK watermarking technique in T-DMB system. By applying the proposed scheme to T-DMB, it allows additional data transmission for disaster broadcasting and improves efficiency of data transmission in shadow region and indoor to mobile environment through watermarking spread code. From the simulation results, we confirm the proposed watermarking scheme affected on the existing T-DMB signal. Moreover, it was also confirmed that the system capacity increases as the power of additional watermarking signal rose. The results of the paper can be applied to wireless multimedia digital broadcasting systems.     

Predictive simulation of human walking transitions using an optimization formulation

A general optimization formulation for transition walking prediction using 3D skeletal model is presented. The formulation is based on a previously presented one-step walking formulation (Xiang et al., Int J Numer Methods Eng 79:667–695, 2009b). Two basic transitions are studied: walk-to-stand and slow-to-fast walk. The slow-to-fast transition is used to connect slow walk to fast walk by using a step-to-step transition formulation. In addition, the speed effects on the walk-to-stand motion are investigated. The joint torques and ground reaction forces (GRF) are recovered and analyzed from the simulation. For slow-to-fast walk transition, the predicted ground reaction forces in step transition is even larger than that of the fast walk. The model shows good correlation with the experimental data for the lower extremities except for the standing ankle profile. The optimal solution of transition simulation is obtained in a few minutes by using predictive dynamics method.     

Superconducting properties of Pb/Ag multilayers

The electrical resistivity, ac susceptibility, critical current density, and Josephson tunneling of Pb/Ag multilayers have been measured in wide temperature ranges in order to study the proximity effect. A resistivity drop was found to occur atT _c of Pb in versusT measurement and, at low temperature, the multilayers show proximity effect. The I-V characteristic of the multilayer shows voltage steps, indicating a resistive state has occurred in the sample. The superconducting properties of the multilayer were analyzed with the bilayer theory of the proximity effect.     

Rapidly solidified titanium alloys for high-temperature applications

The application of rapid solidification technology (RST) to titanium alloy systems is relatively new and became the subject of active research since it was demonstrated that novel titanium alloys of higher temperature capability can be synthesized through new alloy design based on rapid solidification processing. The effects of rapid solidification on the occurrence of metastable phases, microstructures and mechanical properties in binary and ternary titanium alloys are reviewed. In particular, earlier results from RS-Ti alloy research have shown that many different novel dispersoids, some of which are coarsening-resistant at elevated temperatures (600 to 800° C), can be created in the matrix through RST. The alloys containing novel dispersoids also exhibit good creep resistance at elevated temperatures. Further studies on/- and-Ti alloys through RST, in conjunction with the development of various processing technologies for bulk alloy manufacturing, are clearly desirable.     

Identification of Cyclophilin A as a Potential Anticancer Target of Novel Nargenicin A1 Analog in AGS Gastric Cancer Cells

We recently discovered a novel nargenicin A1 analog, 23-demethyl 8,13-deoxynargenicin (compound 9), with potential anti-cancer and anti-angiogenic activities against human gastric adenocarcinoma (AGS) cells. To identify the key molecular targets of compound 9, that are responsible for its biological activities, the changes in proteome expression in AGS cells following compound 9 treatment were analyzed using two-dimensional gel electrophoresis (2-DE), followed by MALDI/TOF/MS. Analyses using chemical proteomics and western blotting revealed that compound 9 treatment significantly suppressed the expression of cyclophilin A (CypA), a member of the immunophilin family. Furthermore, compound 9 downregulated CD147-mediated mitogen-activated protein kinase (MAPK) signaling pathway, including c-Jun N-terminal kinase (JNK) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) by inhibiting the expression of CD147, the cellular receptor of CypA. Notably, the responses of AGS cells to CypA knockdown were significantly correlated with the anticancer and antiangiogenic effects of compound 9. CypA siRNAs reduced the expression of CD147 and phosphorylation of JNK and ERK1/2. In addition, the suppressive effects of CypA siRNAs on proliferation, migration, invasion, and angiogenesis induction of AGS cells were associated with G2/M cell cycle arrest, caspase-mediated apoptosis, inhibition of MMP-9 and MMP-2 expression, inactivation of PI3K/AKT/mTOR pathway, and inhibition of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression. The specific interaction between compound 9 and CypA was also confirmed using the drug affinity responsive target stability (DARTS) and cellular thermal shift assay (CETSA) approaches. Moreover, in silico docking analysis revealed that the structure of compound 9 was a good fit for the cyclosporin A binding cavity of CypA. Collectively, these findings provide a novel molecular basis for compound 9-mediated suppression of gastric cancer progression through the targeting of CypA.