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21.
Magdalena Druszczyska Magdalena Godkowicz Jakub Kulesza Sebastian Wawrocki Marek Fol 《International journal of molecular sciences》2022,23(3)
Cytokine receptors are critical regulators of the antimycobacterial immune response, playing a key role in initiating and coordinating the recruitment and activation of immune cells during infection. They recognize and bind specific cytokines and are involved in inducing intracellular signal transduction pathways that regulate a diverse range of biological functions, including proliferation, differentiation, metabolism and cell growth. Due to mutations in cytokine receptor genes, defective signaling may contribute to increased susceptibility to mycobacteria, allowing the pathogens to avoid killing and immune surveillance. This paper provides an overview of cytokine receptors important for the innate and adaptive immune responses against mycobacteria and discusses the implications of receptor gene defects for the course of mycobacterial infection. 相似文献
22.
Katarzyna Krawczyk Jakub Sawicki 《International journal of molecular sciences》2013,14(6):11376-11391
RNA polymerase type I (plastid-encoded polymerase, PEP) is one of the key chloroplast enzymes. However, the rpo genes that encode its subunits (rpoA, rpoB, rpoC1 and rpoC2) are relatively rapidly evolving sequences. The aim of this study was to investigate the rate of the molecular evolution of rpo genes and to evaluate them as phylogenetic markers on the example of the genus Lamium L. (Lamiaceae). The analyzed genes were shown to differ in the level of variation, rate of intragenic mutations, phylogenetic informativeness, and in the impact of these mutations on the properties of encoded peptides. Destabilizing effects of the positive pressure were observed in all genes examined coding for PEP enzyme. We have demonstrated the relationship between mutations fixed by positive selection and the separation of phylogenetic lines within the genus Lamium. The study showed also that the rpo genes were reliable phylogenetic markers, useful in the reconstruction of interconnections of species belonging to the same genus. Of the four tested genes, the most promising phylogenetic marker was rpoA gene, while the least useful gene appeared to be rpoC1. 相似文献
23.
This paper presents a fully automatic system intended to detect leaks of dielectric fluid in underground high-pressure, fluid-filled (HPFF) cables. The system combines a number of artificial intelligence (AI) and data processing techniques to achieve high detection capabilities for various rates of leaks, including leaks as small as 15 l per hour. The system achieves this level of precision mainly thanks to a novel auto-tuning procedure, enabling learning of the Bayesian network – the decision-making component of the system – using simulated leaks of various rates. Significant new developments extending the capabilities of the original leak detection system described in [1] and [2] form the basis of this paper. Tests conducted on the real-life HPFF cable system in New York City are also discussed. 相似文献
24.
Ivan Kelnar Jakub Rotrekl Ludmila Kaprálková Jiřina Hromádková Adam Strachota 《应用聚合物科学杂志》2012,125(5):3477-3483
The effect of the clay content and the method of its combination with amine-terminated butadiene-acrylonitrile (ATBN) on the structure and behavior of epoxy was studied. In the case of the simultaneous addition of both components, the increasing clay content had a very small effect on the size of the reaction-induced phase separation-formed particles at 5% rubber content due to predominant elimination of two major clay effects, i.e., the nucleation due to phase separation and the kinetics. As a result, both the time window between the onset of phase separation and vitrification and the viscosity at the cloud point did not change significantly. The minor change in the particle size/clay content dependences with different curing temperatures indicates that the balance between the two clay effects shifted. The corresponding study of the mechanical behavior indicated that the best balanced mechanical properties were obtained at certain clay/ATBN ratios, and thus, there was synergy between the components. Similar mechanical parameters were obtained for the application of both components in the form of ATBN/montmorillonite intercalate. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 相似文献
25.
Michał Sójka Elżbieta Klimczak Jakub Macierzyński Krzysztof Kołodziejczyk 《European Food Research and Technology》2013,237(6):995-1007
The objective of the present work was to determine the nutrient and polyphenolic composition of dried strawberry press cake (SPC), as well as that of its seedless fraction, termed exhausted strawberry flesh (ESF). The study materials were obtained over three consecutive years from an industrial facility manufacturing concentrated fruit juices. On average, SPC consists of 40 % seeds, 3.5 % sand, and about 55 % ESF. In the dry matter of SPC and ESF, the mean content of fat is 9.8 and 3.5 %, protein 17.3 and 20.4 %, and total polyphenols 3,449 and 5,410 mg/100 g, respectively. Both materials are rich in total dietary fiber, whose content amounts to 60 %. The predominant polyphenols in SPC and ESF are flavanols and ellagitannins, which collectively constitute over 95 % of the determined total polyphenol content. In ESF composition, of note is the high content of the strawberry ellagitannin, agrimoniin, which is approximately 1,000 mg/100 g DW (dry weight). SPC has the disadvantage of being highly contaminated with sand (3.4 %), which accumulates in ESF (5.6 %). However, as compared to SPC, ESF contains approximately 20 % more proteins and almost three times less fat. Based on our results, it appears that SPC may be considered a potential raw material for seed recovery. Moreover, dried strawberry press cake, and especially its seedless fraction (ESF), despite substantial contamination with sand, may be used as rich and widely available raw material for the extraction of proanthocyanidins and/or ellagitannins, and especially dimeric agrimoniin. 相似文献
26.
Forgetting Exceptions is Harmful in Language Learning 总被引:2,自引:0,他引:2
We show that in language learning, contrary to received wisdom, keeping exceptional training instances in memory can be beneficial for generalization accuracy. We investigate this phenomenon empirically on a selection of benchmark natural language processing tasks: grapheme-to-phoneme conversion, part-of-speech tagging, prepositional-phrase attachment, and base noun phrase chunking. In a first series of experiments we combine memory-based learning with training set editing techniques, in which instances are edited based on their typicality and class prediction strength. Results show that editing exceptional instances (with low typicality or low class prediction strength) tends to harm generalization accuracy. In a second series of experiments we compare memory-based learning and decision-tree learning methods on the same selection of tasks, and find that decision-tree learning often performs worse than memory-based learning. Moreover, the decrease in performance can be linked to the degree of abstraction from exceptions (i.e., pruning or eagerness). We provide explanations for both results in terms of the properties of the natural language processing tasks and the learning algorithms. 相似文献
27.
Jakub Gajewski Jzef Jonak 《Tunnelling and Underground Space Technology incorporating Trenchless Technology Research》2006,21(2):180-184
The paper presents the results of a research work using artificial neural networks to classify the signals of machining forces typical for particular worn cutting tools. Prospectively, a proper classification of these signals may allow the identification of cutter tips condition in multi-tools heads status’ monitoring systems, and facilitate the construction of systems for controlling rocks excavating process. 相似文献
28.
Jakub Zavrel 《Artificial Intelligence Review》1996,10(5-6):477-504
Neural networks have recently been proposed for the construction of navigation interfaces for Information Retrieval systems. In this paper, we give an overview of some current research in this area. Most of the cited approaches use (variants) of the well-known Kohonen network. The Kohonen network implements a topology-preserving dimensionality-reducing mapping, which can be applied for information visualization. We identify a number of problems in the application of Kohonen networks for Information Retrieval, most notably scalability, reliability and retrieval effectiveness. To solve these problems we propose to use the Growing Cell Structures network, a variant of the Kohonen network which shows a more flexible adaptation to the domain structure.This network was tested on two standard test-collections, using a combined recall and precision measure, and compared to traditional IR methods such as the Vector Space Model and various clustering algorithms. The network performs at a competitive level of effectiveness, and is suitable for visualization purposes. However, the incremental training procedures for the networks result in a reliability problem, and the approach is computationally intensive. Also, the utility of the resulting maps for navigation will need further improvement. 相似文献
29.
We aim to reduce the social cost of congestion in many smart city applications. In our model of congestion, agents interact over limited resources after receiving signals from a central agent that observes the state of congestion in real time. Under natural models of agent populations, we develop new signalling schemes and show that by introducing a non-trivial amount of uncertainty in the signals, we reduce the social cost of congestion, i.e., improve social welfare. The signalling schemes are efficient in terms of both communication and computation, and are consistent with past observations of the congestion. Moreover, the resulting population dynamics converge under reasonable assumptions. 相似文献
30.
This article presents a study on the novel method of model reference adaptive control (MRAC). As a new contribution, the derivative action is included into MRAC control to improve the controller performance and efficiency. The stability is analysed using a recent technique called immersion and invariance. The simulations of derived laws are presented based on nonlinear models. 相似文献