Referenzprozesse für elektronische Ausschreibungen aus Sicht des industriellen Einkaufs

Many companies and purchasing departments only possess a limited knowledge about the modelling of inter-company business processes for electronic procurement. In the past the discussion about electronic procurement was mostly focused on technical aspects. This article introduces a reference process model for procurement auctions. The process model is made up of a basic process, which describes a minimal process for procurement auctions, and a number of process alternatives, which allow for the adoption of the basic process to changing parameters and individual company requirements.     

Thermal and mechanical properties of epoxy composites reinforced by a natural hydrophobic sand

If a low weight percentage of crude fine fillers can improve properties of polymer materials directly without complicated chemical treatment process involved, it will be significant for many industrial applications. Our previous study indicated that a kind of Cancun natural sand could be an effective filler material for polymer composites. In this current work, the epoxy composites reinforced by this kind of natural sand particles were prepared and thermal and mechanical properties of the composites containing up to 5 wt % of the sand particles were characterized. Results showed that the highest flexural strength appears in the epoxy composite containing 1 wt % sand particles. A damage model was used to interpret the flexural properties, which showed an acceptable agreement with the experimental results. The glass transition temperature, high temperature storage modulus, and dimensional stability of the sand/epoxy composites monotonically increased with the addition of the sand particles. The sand particle/epoxy composites also displayed a noticeable enhancement in thermal conductivity. Theoretical analysis showed that in addition to conduction, other heat transport mechanisms played roles in the improved heat transmission through the composites. As a natural porous micron-scale material, Cancun sand has the potential for applications in cost-effective composites with enhanced mechanical and thermal properties. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008     

Hartstoffschichten für das Pressen und Prägen von Gläsern bei hohen Temperaturen

Hard and wear resistant coatings for the moulding and embossing of glasses at elevated temperatures Hard and wear resistant coatings of Titanium Aluminium Nitride TiAlN were deposited on various substrates by the application of different reactive deposition processes: RF-magnetron-sputtering, ion beam-sputtering and by the energetic cluster impact (ECI) process. The deposition of the coatings was performed under variation of biasing conditions and of process parameters such as pressures and flow rates of the process gases argon and nitrogen as well as of energies of species hitting the substrate surfaces. The microstructure particularly the growth morphology of several films was investigated by pictures of film cross sections recorded by transmission electron microscopy. Residual intrinsic film stresses were analyzed by measuring deflections of substrates in an interference optical microscope before and after the deposition of the coatings. By heating coated substrates and in-situ observation of deflections at elevated temperatures dependencies of thermally induced stresses on temperatures and variations of intrinsic stresses due to changes within the films could be analyzed and related to microstructure and growth conditions. In the paper specific characteristics of the deposition processes occuring on the scale both of atoms and of clusters which may contain several thousand of atoms are described and related to microstructure, residual stress states and damaging conditions. Different contributions to residual film stresses are analyzed on the base of theoretical considerations taking into account deposition kinetics and thermomecanical properties. The significance of achieved film properties for application, i. e. for the coating of tools for the manufacturing of optical components by moulding and embossing of glasses is discussed.     

Photochemical identification of transmembrane segment IVS6 as the binding region of semotiadil, a new modulator for the L-type voltage-dependent Ca2+ channel

To identify the binding domain of a new Ca2+ antagonist semotiadil on L-type Ca2+ channels from skeletal muscle, photolabeling was carried out by using an azidophenyl derivative of [3H]semotiadil. Photoincorporation was observed in several polypeptides of membrane triad preparations; the only specific photoincorporation was in the alpha1 subunit of the Ca2+ channel. After solubilization and purification, the photolabeled alpha1 subunit was subjected to proteolytic and CNBr cleavage followed by antibody mapping. Specific labeling was associated solely with the region of transmembrane segment S6 in repeat IV. Quantitative immunoprecipitation was found in the tryptic and the Lys-C/Glu-C fragments of 6.6 and 6.1 kDa, respectively. Further CNBr cleavage of the Lys-C digests produced two smaller fragments of 3.4 and 1.8 kDa that were included in the tryptic and Lys-C/Glu-C fragments. The smallest labeled fragments were: Tyr1350-Met1366 and Leu1367-Met1381 containing IVS6, a possible pore-forming region. The data suggest that semotiadil binds to a region that is overlapped with but not identical to those for phenylalkylamines, dihydropyridines and benzothiazepines. The present study also provides evidence that region IV represents an important component of a binding pocket for Ca2+ antagonists.     

Modulation of the allergic immune response in BALB/c mice by subcutaneous injection of high doses of the dominant T cell epitope from the major birch pollen allergen Bet v 1

Several in vitro and in vivo studies indicate that application of high doses of dominant T cell epitopes can induce a state of antigen-specific non-responsiveness (anergy). In the present study, we developed a murine model of an allergic immune response to Bet v 1, the major birch pollen allergen. Mice were sensitized by injection of rBet v 1 and the allergic state was proven by the presence of allergen-specific IgE and positive immediate-type skin tests to Bet v 1. In epitope mapping experiments, an immunodominant T cell epitope of Bet v 1 in BALB/c mice was identified by the use of overlapping peptides. This peptide (BV 139) was subsequently employed for treatment. Two tolerization protocols were used: in one approach, the peptide was administered to naive mice before immunization (group BV139-S), in the second, already sensitized mice were treated (S-BV139). The results demonstrated that administering high doses of the dominant T cell epitope of Bet v 1 profoundly diminished T cell proliferation to the peptide in the BV139-S group, and to the peptide as well as to the whole protein in the S-BV139 group. Skin test reactivity to Bet v 1 was reduced in the BV139-S group. However, no differences in terms of specific antibody production between treated and untreated mice could be observed. This study provides evidence that administration of dominant T cell epitopes can down-regulate the allergen-specific T cell response. Proceeding on the assumption that the T lymphocyte response to allergens is crucial for the induction and maintenance of the allergic disease, a modulation of the immune response to allergens by treatment with T cell epitope peptides could represent a promising concept for immunotherapy in the future.     

Studies on the electrical conductivity and galvanomagnetic characteristics of short carbon fibre filled thermoplastic elastomers

The electrical resistivity of short carbon fibre filled thermoplastic elastomers based on natural rubber-high density polyethylene (NR-HDPE) blend and styrene-isoprene-styrene (S-I-S) block copolymer has been studied by varying the concentration of fibre from the 0 to 40 phr level. A sharp drop in resistivity is observed in both cases after a critical concentration of fibre is reached, with the S-I-S system showing lower values of critical concentration. At higher concentrations, experimental values of the electrical conductivity agreed reasonably well with the calculated values from a theory based on the probability of formation of a conductive network. The effect of temperature on the resistivity of the composites has also been investigated in a temperature range of 27–120 °C and 27–90 °C for the NR-HDPE system and S-I-S system, respectively. The type of carrier in both the composites is found to be n-type, i.e. electrons, and the activation energy of hopping of the electrons for both the systems has been calculated. A Hall effect study has also been carried out to determine the carrier concentration and drift mobility of both the composites.     

Is there a role for continuation phase cognitive therapy for depressed outpatients?

Two pilot studies evaluated the rate of relapse or recurrence (i.e., major depressive disorder) after cognitive therapy (CT). Two sequential cohorts included outpatients who responded to acute phase CT (A-CT) and who agreed to monthly, treatment-free follow-up. In Study 1, the Kaplan-Meier technique estimated relapse and recurrence rates of 40% at 6 months, 45% at 8 months, 50% at 12 months, 67% at 18 months, and 74% at 24 months. In Study 2, responders to A-CT received 8 months (10 sessions) of continuation phase CT (C-CT). In Study 2, relapse or recurrence was 20% at 6 and 8 months, 27% at 12 months, and 36% at 18 and 24 months after A-CT. An exploratory log-rank test showed that relapse or recurrence-free survival was greater in Study 2 than in Study 1. If replicated, this result suggests that C-CT can reduce depressive relapse or recurrence. Alternative explanations are presented. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Silicon oxide thin films prepared by a photo-chemical vapour deposition technique

Wide band gap a-SiO_x:H films have been prepared by the photochemical decomposition of a SiH₄, CO₂ and H₂ gas mixture. Deposition parameters namely the CO₂ to SiH₄ gas flow ratio, H₂ dilution and chamber pressure were optimized in order to achieve highly photoconducting (1 × 10^-6 S cm^-1) films with an optical gap of 1.99 eV. The optical gap was found to increase with an increase in the CO₂ to SiH₄ flow ratio. A decrease in the photoconductivity, refractive index, spin g-value and a simultaneous increase in the spin density are attributed to an incorporation of oxygen into the films. Upon hydrogen dilution the photoconductivity of a-SiO_x:H films was observed to improve along with an increase of the optical gap. The spin density of a-SiO_x:H films was of the order of 10¹⁷ cm^-9. The optoelectronic properties of the films have been correlated with the bonding configurations in the film, deposition parameters and the growth kinetics. This revised version was published online in November 2006 with corrections to the Cover Date.