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排序方式: 共有1738条查询结果,搜索用时 15 毫秒
81.
Biswajit Basu Santhanu Jana G. S. Reddy J. A. Sekhar 《JOM Journal of the Minerals, Metals and Materials Society》2002,54(8):39-43
A comparison is made of die temperature uniformity for two heating configurations: electric air heating and flame heating.
The temperature uniformity with electric air heating is noted to be substantially superior to flame heating of large dies.
The simulation results are compared with experimentally obtained numbers and found to be in agreement. 相似文献
82.
Lubomír Pospíšil Magdaléna Hromadová Jana Bulí?ková Salvatore Filippone Zhu Guan Yongmin Zhang 《Carbon》2010,48(1):153-1408
The formal redox potentials of electron transfer reactions of fullerene, methanofullerene, fullerene-cyclodextrin complex and methanofullerene conjugates with cyclodextrins in aqueous and dimethylsulfoxide solutions are reported. These new compounds are surface active and retain the redox activity of C60 even in aqueous medium. Compounds have been characterized by an electrochemical admittance technique, which offers an advantage of separating faradaic and capacitive properties. Observed difference of formal redox potentials of the free fullerene forms and their cyclodextrin-containing compounds were used to determine the binding enhancement. Results are interpreted in terms of inter-molecular host-guest interactions of C60-cyclodextrin conjugates. 相似文献
83.
Lucie Vitejnov Vclav Lika Arvind Kumar Jana Ke
kov Ondej Vy
ítal Jan Brha Jan Bene Yaroslav Kolinko Tereza Blassov Zbynk Tonar Michaela Brychtov Marie Karlíkov Jaroslav Racek Hynek Mírka Petr Hoek Daniel Lysk Milena Krlí
kov 《International journal of molecular sciences》2021,22(9)
In liver surgery, biliary obstruction can lead to secondary biliary cirrhosis, a life-threatening disease with liver transplantation as the only curative treatment option. Mesenchymal stromal cells (MSC) have been shown to improve liver function in both acute and chronic liver disease models. This study evaluated the effect of allogenic MSC transplantation in a large animal model of repeated biliary obstruction followed by partial hepatectomy. MSC transplantation supported the growth of regenerated liver tissue after 14 days (MSC group, n = 10: from 1087 ± 108 (0 h) to 1243 ± 92 mL (14 days); control group, n = 11: from 1080 ± 95 (0 h) to 1100 ± 105 mL (14 days), p = 0.016), with a lower volume fraction of hepatocytes in regenerated liver tissue compared to resected liver tissue (59.5 ± 10.2% vs. 70.2 ± 5.6%, p < 0.05). Volume fraction of connective tissue, blood vessels and bile vessels in regenerated liver tissue, serum levels of liver enzymes (AST, ALT, ALP and GGT) and liver metabolites (albumin, bilirubin, urea and creatinine), as well as plasma levels of IL-6, IL-8, TNF-α and TGF-β, were not affected by MSC transplantation. In our novel, large animal (pig) model of repeated biliary obstruction followed by partial hepatectomy, MSC transplantation promoted growth of liver tissue without any effect on liver function. This study underscores the importance of translating results between small and large animal models as well as the careful translation of results from animal model into human medicine. 相似文献
84.
Betty Berezovsky Martin Bje
ný Jana Frýdlov Iuliia Gurieva Daniel Wayne Rogalsky Petr Pikryl Vít Pospíil Emanuel Ne
as Martin Vokurka Jan Krijt 《International journal of molecular sciences》2021,22(15)
Erythropoietin (EPO) downregulates hepcidin expression to increase the availability of iron; the downregulation of hepcidin is mediated by erythroferrone (ERFE) secreted by erythroblasts. Erythroblasts also express transferrin receptor 2 (TFR2); however, the possible role of TFR2 in hepcidin downregulation is unclear. The purpose of the study was to correlate liver expression of hepcidin with the expression of ERFE and TFR2 in murine bone marrow and spleen at 4, 16, 24, 48, 72 and 96 h following administration of a single dose of EPO. Splenic Fam132b expression increased 4 h after EPO injection; liver hepcidin mRNA was decreased at 16 h. In the spleen, expression of TFR2 and transferrin receptor (TFR1) proteins increased by an order of magnitude at 48 and 72 h after EPO treatment. The EPO-induced increase in splenic TFR2 and TFR1 was associated with an increase in the number of Tfr2- and Tfr1-expressing erythroblasts. Plasma exosomes prepared from EPO-treated mice displayed increased amount of TFR1 protein; however, no exosomal TFR2 was detected. Overall, the results confirm the importance of ERFE in stress erythropoiesis, support the role of TFR2 in erythroid cell development, and highlight possible differences in the removal of TFR2 and TFR1 from erythroid cell membranes. 相似文献
85.
Fabian Essig Lilith Babilon Christoph Vollmuth Alexander M. Kollikowski Mirko Pham Lszl Solymosi Karl Georg Haeusler Peter Kraft Guido Stoll Michael K. Schuhmann 《International journal of molecular sciences》2021,22(20)
High-mobility group box 1 protein (HMGB1) is a damage-associated molecular pattern (DAMP) involved in neutrophil extracellular trap (NET) formation and thrombosis. NETs are regularly found in cerebral thromboemboli. We here analyzed associated HMGB1 expression in human thromboemboli retrieved via mechanical thrombectomy from 37 stroke patients with large vessel occlusion. HMGB1 was detected in all thromboemboli, accounting for 1.7% (IQR 0.6–6.2%) of the total thromboemboli area and was found to be colocalized with neutrophils and NETs and in spatial proximity to platelets. Correlation analysis revealed that the detection of HMGB1 was strongly related to the number of neutrophils (r = 0.58, p = 0.0002) and platelets (r = 0.51, p = 0.001). Our results demonstrate that HMGB1 is a substantial constituent of thromboemboli causing large vessel occlusion stroke. 相似文献
86.
87.
Petra Chocholata Vlastimil Kulda Jana Dvorakova Monika Supova Margit Zaloudkova Vaclav Babuska 《International journal of molecular sciences》2021,22(17)
Bone tissue engineering tries to simulate natural behavior of hard tissues. This study aimed to produce scaffolds based on polyvinyl alcohol (PVA) and hyaluronic acid (HA) with hydroxyapatite (HAp) incorporated in two different ways, by in situ synthesis and physical mixing of pre-prepared HAp. In situ synthesis resulted in calcium deficient form of HAp with lower crystallinity. The proliferation of human osteoblast-like cells MG-63 proved to be better in the scaffolds with in situ synthesized HAp compared to those with physically mixed pre-prepared HAp. For scaffolds with PVA/HA/HAp ratio 3:1:2, there was significantly higher initial adhesion (p = 0.0440), as well as the proliferation in the following days (p < 0.001). It seemed to be advantageous improve the properties of the scaffold by in situ synthesizing of HAp directly in the organic matrix. 相似文献
88.
A. Kraft M. Blaschke D. Kreysig B. Sandt F. Schröder J. Rennau 《Journal of Applied Electrochemistry》1999,29(8):895-902
The electrolytic production of hypochlorite from tap water in a flow-through reactor system is investigated using stacked platinum or iridium oxide coated titanium sheet or expanded metal electrodes. The influence of fast chlorine consumption and polarity reversal on the hypochlorite production rate was determined along with the dependence of the hypochlorite production rate on temperature, flow through velocity and current density. It was found that in most cases, the hypochlorite production rate was higher on iridium oxide compared to platinum electrodes. An increase in the flow-through velocity leads to an increased hypochlorite production rate while the hypochlorite production rate falls with increasing temperature. 相似文献
89.
Temporal trends of synthetic musk compounds in mother's milk and associations with personal use of perfumed products 总被引:3,自引:0,他引:3
Lignell S Darnerud PO Aune M Cnattingius S Hajslova J Setkova L Glynn A 《Environmental science & technology》2008,42(17):6743-6748
We analyzed two nitro musks (musk xylene and musk ketone) and five polycyclic musks (HHCB, AHTN, ADBI, ATII, and AHDI) in mother's milk from primiparae women (N = 101) living in Uppsala County, Sweden, 1996-2003. Possible temporal trends in musk concentrations and associations with lifestyle/medical factors, such as use of perfumed products during pregnancy were studied. HHCB showed the highest median concentration (63.9 ng/g lipid) followed by AHTN (10.4 ng/g) and musk xylene (MX) (9.5 ng/g). Concentrations of the other substances were, in most cases, below the quantification limit (2.0-3.0 ng/g). Women with a high use of perfume during pregnancy had elevated milk concentrations of HHCB, and elevated concentrations of AHTN were observed among women reporting use of perfumed laundry detergent. This strongly suggests that perfumed products are important sources of musk exposure both among the mothers and the nursed infants. Concentrations of AHTN and MX declined significantly between 1996 and 2003, suggesting a decline in the industrial use of the compounds in consumer products, or alterations in the consumer use pattern of perfumed products. No temporal trend in HHCB concentrations was seen. The lack of toxicity data makes it difficult to generalize about the safety of musk exposure of breast-fed infants. 相似文献
90.
Serum concentrations of neutral and phenolic organohalogens in pregnant women and some of their infants in The Netherlands 总被引:2,自引:0,他引:2
Meijer L Weiss J Van Velzen M Brouwer A Bergman A Sauer PJ 《Environmental science & technology》2008,42(9):3428-3433
As part of a large European Union (EU)-funded comparative toxicology and human epidemiology study, EU-Compare, a selection of organohalogen compounds (OHCs) was analyzed in maternal serum, collected at the 35th week of pregnancy, and in cord serum of a number of their infants to determine maternal concentrations and to investigate the extent of transplacental transfer of these compounds. Eight neutral OHCs were analyzed: one polychlorinated biphenyl (PCB: CB-153),4,4'-DDE, five polybrominated diphenyl ethers (PBDEs: BDE-47, BDE-99, BDE-100, BDE-153, and BDE-154), and hexabromocyclododecane (HBCDD). Five phenolic OHCs were analyzed: three hydroxylated PCBs (40H-CB-107, 40H-CB-146, and 40H-CB-187), one hydroxylated PBDE (60H-BDE-47), and pentachlorophenol (PCP). All OHCs, except 60H-BDE-47, were present in maternal and cord serum. The historically identified OHCs showed the highest concentration: 4,4'-DDE (median value 89 ng/g lipid in maternal serum and 68 ng/g lipid in cord serum) and PCP (median value 970 pg/g serum in maternal serum and 1500 pg/g serum in cord serum). HBCDD and the PBDEs were present at much lower concentrations. We conclude that OHCs are present in the serum of pregnant women, and all compounds tested are transferred over the placenta. Because transfer is occurring at a critical stage of infant development, investigation of the health impact is urgent. 相似文献