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81.
Nonlinear normal mode (NNM) vibration, in a nonlinear dual mass Hamiltonian system, which has 6th order homogeneous polynomial as a nonlinear term, is studied in this paper. The existence, bifurcation, and the orbital stability
of periodic motions are to be studied in the phase space. In order to find the analytic expression of the invariant curves
in the Poincare Map, which is a mapping of a phase trajectory onto 2 dimensional surface in 4 dimensional phase space, Whittaker’s
Adelphic Integral, instead of the direct integration of the equations of motion or the Birkhoff-Gustavson (B-G) canonical
transformation, is derived for small value of energy. It is revealed that the integral of motion by Adelphic Integral is essentially
consistent with the one obtained from the B-G transformation method. The resulting expression of the invariant curves can
be used for analyzing the behavior of NNM vibration in the Poincare Map. 相似文献
82.
Keun Byoung Yoon In-Kui Cho Seung Ho Ahn Myung Yong Jeong Deug Ju Lee Young Un Heo Byung Sup Rho Hyo-Hoon Park Byoung-Ho Rhee 《Lightwave Technology, Journal of》2004,22(9):2119-2127
As discussed in this paper, a practical optical backplane system was demonstrated, using a waveguide-embedded optical backplane board, processing boards, and optical slots for board-to-board interconnection. A metal optical bench was used as a packaging die for the optical devices and the integrated circuit chips in both the transmitter and the receiver processing boards. The polymer waveguide was produced by means of a hot-embossing technique and was then embedded following a conventional lamination processes. The average propagation loss of these waveguides was approximately 0.1 dB/cm at 850 nm. The dimension and optical properties of the waveguide in an optical backplane board were unchanged after lamination. As connection components between transmitter/receiver processing boards and an optical backplane board, optical slots were used for easy and repeatable insertion and extraction of the boards with a micrometer-scale precision. A 1/spl times/4 850-nm vertical-cavity surface-emitting laser array was used with 2 dBm of output power for the transmitter and a p-i-n photodiode array for the receiver. This paper successfully demonstrates 8 Gb/s of data transmission between the transmitter processing board and the optical backplane board. 相似文献
83.
Evaluation of the control performance of hydronic radiant heating systems based on the emulation using hardware-in-the-loop simulation 总被引:1,自引:0,他引:1
This study presents an emulation method to evaluate the control performance of a hydronic radiant heating system. Since heat output in the system is dependent on the pressure loss and flow rate in the hydronic network, the interaction between thermal and hydronic models needs to be considered in the evaluation of the control performance. For this reason, many studies apply an integrated simulation to the evaluation; however, the analysis of the hydronic network sometimes leads to unreliable results due to the improper initial values for algebraic loops or the lack of modeling information on the hydronic components. In order to deal with this problem, this study suggests an emulation method, where the hydronic network is replaced by real hardware and the building physics is analyzed by a simulation. In the emulation, the pressure loss and flow rate in the hydronic network were represented by replacing the real pipe with equivalent hydraulic resistance. In addition, by using real control systems that connect the hydronic network and building simulation, the interaction between building physics and hydronic network could be considered in the evaluation. Based on the proposed emulation method, the performance of several control strategies was evaluated in terms of the accuracy and the rise time. The result shows that the individual control needs to be combined with hydronic balancing for more accurate control. Hydronic control devices such as a flow limit valve and a pressure differential control valve also proved to be helpful to the improvement of the control performance. 相似文献
84.
Gwangbeom Heo Yuju Kim Eun-La Kim Soyeong Park Sang Hoon Rhee Jee H. Jung Eunok Im 《International journal of molecular sciences》2023,24(1)
Atractylodin is a major compound in the rhizome of Atractylodes lancea, an oriental herbal medicine used for the treatment of gastrointestinal diseases, including dyspepsia, nausea, and diarrhea. Recent studies have shown that atractylodin exerts anti-inflammatory effects in various inflammatory diseases. Herein, we investigated the anti-colitis effects of atractylodin and its molecular targets. We determined the non-cytotoxic concentration of atractylodin (50 μM) using a cell proliferation assay in colonic epithelial cells. We found that pretreatment with atractylodin significantly inhibits tumor necrosis factor-α-induced phosphorylation of nuclear factor-κ-light-chain-enhancer of activated B in HCT116 cells. Through docking simulation analysis, luciferase assays, and in vitro binding assays, we found that atractylodin has an affinity for peroxisome proliferator-activated receptor alpha (PPARα). Daily administration of atractylodin (40 mg/kg) increased the survival rate of mice in a dextran sodium sulfate-induced colitis mouse model. Thus, atractylodin can be a good strategy for colitis therapy through inducing PPARα-dependent pathways. 相似文献
85.
Photosystem II is a multisubunit enzyme complex involved in plant photosynthesis. It uses solar energy to catalyse the breakdown of water to reducing equivalents and molecular oxygen. Native photosystem II comprises more than 25 different subunits, and has a relative molecular mass of more than 600K. Here we report the three-dimensional structure of a photosystem II subcomplex, containing the proteins D1, D2, CP47 and cytochrome b-559, determined by electron crystallography. This CP47 reaction centre, which has a relative molecular mass of 160K, can perform light-mediated energy and electron-transfer reactions but is unable to oxidize water. The complex contains 23 transmembrane alpha-helices, of which 16 have been assigned to the D1, D2 and CP47 proteins. The arrangement of these helices is remarkably similar to that of the helices in the reaction centres of purple bacteria and of plant photosystem I, indicating a common evolutionary origin for these assemblies. The map suggests that redox cofactors in the D1-D2 complex are located in positions analogous to those in the bacterial reaction centre, but the distance between the chlorophylls corresponding to the bacterial 'special pair' is significantly larger. 相似文献
86.
We have used computer modeling of insulin 3-D structure and experimental data about action of site point mutation on insulin activity to design functionally important domain with signaling activity and synthesized peptide than might be sufficient for the binding to insulin receptor. The designed and synthesized peptide consist of ten residues and may be obtained in two forms: oxidized and reduced (with or without disulfide bond). The synthesized decapeptide peptide represents functionally important site for binding to the insulin receptor. Amino acid residues at position 1-8 correlate with B-chain of insulin at position (B19-B26). Residues at position 9.10 correlate with A-chain at position A-10-A21. This peptide was tested with cell culture L-929 (glucose uptake) in comparison with bioactive commercial peptide (R-G-FF) and insulin. It was shown that synthesized peptide exhibit biological activity at molar concentration 0.01-1 mkM. Our results successfully demonstrate the synthetic insulin fragment have insulin-like biological activity. 相似文献
87.
The error performance of a modulation code over a channel depends on several distance parameters and the path multiplicity of the code. For the AWGN channel, the error performance of a modulation code depends mainly on its minimum squared Euclidean distance and path multiplicity. For the Rayleigh fading channel, however, the error performance of a modulation code depends strongly on its minimum symbol distance, minimum product distance, and path multiplicity. It depends on the minimum squared Euclidean distance in a lesser degree. This paper is concerned with the construction of block and trellis MPSK modulation codes for the Rayleigh fading channel. In each construction, the distance parameters are chosen to achieve good error performance with reduced decoding complexity 相似文献
88.
LE Rameh SG Rhee K Spokes A Kazlauskas LC Cantley LG Cantley 《Canadian Metallurgical Quarterly》1998,273(37):23750-23757
It has been demonstrated that the lipid products of the phosphoinositide 3-kinase (PI3K) can associate with the Src homology 2 (SH2) domains of specific signaling molecules and modify their actions. In the current experiments, phosphatidylinositol 3,4, 5-trisphosphate (PtdIns-3,4,5-P3) was found to bind to the C-terminal SH2 domain of phospholipase Cgamma (PLCgamma) with an apparent Kd of 2.4 microM and to displace the C-terminal SH2 domain from the activated platelet-derived growth factor receptor (PDGFR). To investigate the in vivo relevance of this observation, intracellular inositol trisphosphate (IP3) generation and calcium release were examined in HepG2 cells expressing a series of PDGFR mutants that activate PLCgamma with or without receptor association with PI3K. Coactivation of PLCgamma and PI3K resulted in an approximately 40% increase in both intracellular IP3 generation and intracellular calcium release as compared with selective activation of PLCgamma. Similarly, the addition of wortmannin or LY294002 to cells expressing the wild-type PDGFR inhibited the release of intracellular calcium. Thus, generation of PtdIns-3,4,5-P3 by receptor-associated PI3K causes an increase in IP3 production and intracellular calcium release, potentially via enhanced PtdIns-4, 5-P2 substrate availability due to PtdIns-3,4,5-P3-mediated recruitment of PLCgamma to the lipid bilayer. 相似文献
89.
90.