Environmental behavior of the chiral acetamide pesticide metalaxyl: enantioselective degradation and chiral stability in soil

Racemic metalaxyl is currently being replaced in many countries by metalaxyl-M, the fungicide enantiomerically enriched with the biologically active R-enantiomer. This "chiral switch" is expected to reduce the amount of pesticide released into the environment as well as potential side-effects on nontarget organisms. Detailed knowledge of the environmental behavior of such chiral compounds should include information on the chiral stability (interconversion of enantiomers). In the present study, the degradation/ dissipation of metalaxyl and its primary carboxylic acid metabolite (MX-acid) in soil was investigated under laboratory conditions using enantioselective gas chromatography mass spectrometry (GC-MS). Racemic and the enantiopure R- and S-compounds were incubated in separate experiments. The degradation of metalaxyl was shown to be enantioselective with the fungicidally active R-enantiomer being faster degraded than the inactive S-enantiomer, resulting in residues enriched with S-metalaxyl when the racemic compound was incubated. The relatively high enantioselectivity suggests that degradation/dissipation was largely biological. The data indicated a conversion of 40-50% of metalaxyl to MX-acid, and the remaining metalaxyl being degraded via other pathways. The degradation of MX-acid was also enantioselective. Metalaxyl and MX-acid were both configurationally stable in soil, showing no interconversion of R- to S-enantiomers, and vice-versa. Furthermore, the conversion of metalaxyl to MX-acid proceeded with retention of configuration. Degradation followed approximate first-order kinetics but showed significant lag phases.     

Mumford-Shah model for one-to-one edge matching.

This paper presents a new algorithm based on the Mumford-Shah model for simultaneously detecting the edge features of two images and jointly estimating a consistent set of transformations to match them. Compared to the current asymmetric methods in the literature, this fully symmetric method allows one to determine one-to-one correspondences between the edge features of two images. The entire variational model is realized in a multiscale framework of the finite element approximation. The optimization process is guided by an estimation minimization-type algorithm and an adaptive generalized gradient flow to guarantee a fast and smooth relaxation. The algorithm is tested on T1 and T2 magnetic resonance image data to study the parameter setting. We also present promising results of four applications of the proposed algorithm: interobject monomodal registration, retinal image registration, matching digital photographs of neurosurgery with its volume data, and motion estimation for frame interpolation.     

Interactions of Fibroblasts with Different Morphologies Made of an Engineered Spider Silk Protein

Spider silk has been investigated for decades due to the intriguing mechanical and also biomedical properties of the silk fibers. Previously, it has been shown that recombinant silk proteins can also be processed into other morphologies. Here, we characterized scaffolds made of the recombinant spider silk protein eADF4(C16) concerning their surface interactions with fibroblasts. Studies of BALB/3T3 cells on hydrogels and films made of eADF4(C16) showed low cell adhesion without observable duplication. Electro‐spun non‐woven scaffolds made of eADF4(C16), however, enabled both their adhesion and proliferation. Since eADF4(C16) lacks specific motifs for cell attachment, fibroblasts cannot generate focal adhesions with the material's surface, and, therefore, other cell–interface interactions such as topographical anchorage or cell attachment mediated by adhesion of extracellular matrix proteins are discussed in this paper. On non‐woven meshes protrusion of filopodia and/or lamellipodia between individual fibers increase the surface contact area, which depends on the diameter of the fibers of the non‐woven meshes. In contrast, at flat (film) or microstructured surfaces (hydrogels) such interactions seem to be precluded.     

The BER analysis of OFDMA and SC‐FDMA under pilot‐assisted channel estimation and pilot jamming in rayleigh slow‐fading channel

In this paper, the authors derived the analytical bit error rate expressions for orthogonal frequency division multiple access and single‐carrier frequency‐division multiple access (SC‐FDMA) in Rayleigh slow‐fading channel for binary phase‐shift keying/quadrature phase‐shift keying/16‐quadrature amplitude modulations under pilot jamming and pilot symbol‐assisted channel estimation. Beginning with the bit error rate analysis from the general case of pilot symbol‐assisted channel estimation technique in Rayleigh slow‐fading channel, the expressions are first modified for different modulations and then further customized to account for the Zero‐Forcing equalization in frequency or time direction with application respectively to orthogonal frequency division multiple access or SC‐FDMA without and with pilot jamming. Piecewise‐linear interpolation is used for its simplicity. The simulation results match perfectly with the theoretical predictions except for some discrepancies with SC‐FDMA, which imply that the generalized equations developed here have to be further modified to account for system‐specific features like discrete Fourier transform precoding for SC‐FDMA. Copyright © 2016 John Wiley & Sons, Ltd.     

Material requirements for the adoption of unconventional silicon crystal and wafer growth techniques for high‐efficiency solar cells

Silicon wafers comprise approximately 40% of crystalline silicon module cost and represent an area of great technological innovation potential. Paradoxically, unconventional wafer‐growth techniques have thus far failed to displace multicrystalline and Czochralski silicon, despite four decades of innovation. One of the shortcomings of most unconventional materials has been a persistent carrier lifetime deficit in comparison to established wafer technologies, which limits the device efficiency potential. In this perspective article, we review a defect‐management framework that has proven successful in enabling millisecond lifetimes in kerfless and cast materials. Control of dislocations and slowly diffusing metal point defects during growth, coupled to effective control of fast‐diffusing species during cell processing, is critical to enable high cell efficiencies. To accelerate the pace of novel wafer development, we discuss approaches to rapidly evaluate the device efficiency potential of unconventional wafers from injection‐dependent lifetime measurements. Copyright © 2015 John Wiley & Sons, Ltd.     

Surfing the web - Recreation or resource? Exploring how young people in the UK use the Internet as an advice portal for problems with a legal dimension

Internet use and access in the UK has increased rapidly in the last decade, with the concept of ‘information superhighway’ recognised as an axiom of Internet technology. Despite this, few studies have sought to investigate the incidence of use of the Internet as an advice resource outside of the health information arena. With an increasing impetus in the public sector towards the provision of online delivery mechanisms for civic orientated activities, including advice provision, it is timely to better understand the appropriateness of online advice seeking. Focusing on young people aged between 18 and 24 years, we investigated how much the Internet was used to obtain information about everyday problems with a legal dimension, who used it, how it was used and how successful respondents were in searching for information online. Data were extracted from a large-scale household survey of adults’ experience of problems with a legal dimension conducted across England and Wales (10,512 adult respondents). Results revealed significant growth in the use of the Internet to obtain information about such problems, rising from 4% in 2001 to around 18% in 2008. The responses of the 18-24 year olds to the survey illustrated that despite having comparatively high levels of Internet access, this age group utilised it to a lesser degree than similarly ‘connected’ age cohorts, and were less successful when doing so. This study highlights aspects of the second digital divide, going beyond access to explore use and outcomes of use. Implications for the future of the Internet in providing information and advice for young people, are discussed.     

Micro-Raman temperature measurements for electric field assessment in active AlGaN-GaN HFETs

Temperature profiles in the source/drain (S/D) opening of a single finger AlGaN-GaN heterostructure field-effect transistor were studied at increasing S/D voltages by micro-Raman spectroscopy with <1 /spl mu/m spatial resolution. These profiles imply high field regions near the gate edge of length /spl sim/0.4 /spl mu/m for S/D voltages between 45 and 75 V. Electric field strengths of /spl sim/1.2 and /spl sim/1.9 MV/cm are estimated for 45 and 75 V S/D voltage. The experimental results are in excellent agreement with 2-D Monte Carlo simulations.     

Line focusing for soft x-ray laser-plasma lasing

A computational study of line-focus generation was done using a self-written ray-tracing code and compared to experimental data. Two line-focusing geometries were compared, i.e., either exploiting the sagittal astigmatism of a tilted spherical mirror or using the spherical aberration of an off-axis-illuminated spherical mirror. Line focusing by means of astigmatism or spherical aberration showed identical results as expected for the equivalence of the two frames of reference. The variation of the incidence angle on the target affects the line-focus length, which affects the amplification length such that as long as the irradiance is above the amplification threshold, it is advantageous to have a longer line focus. The amplification threshold is physically dependent on operating parameters and plasma-column conditions and in the present study addresses four possible cases.