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排序方式: 共有197条查询结果,搜索用时 15 毫秒
91.
Traumatic spinal cord injury (SCI) produces lower urinary tract (LUT) dysfunction that has been studied in surgical transection models. Our aim was to assess LUT functional deficit in a clinically relevant model of incomplete SCI to investigate how partial preservation of supraspinal connections might affect LUT dysfunction. Standardized weight-drop contusion (10 g x 2.5 cm) or complete transection, was produced at T8 in female Sprague-Dawley rats. Behavioral tests were used to assess hind limb sensorimotor function at Day 1 after surgery and weekly thereafter. The urometric experiments were conducted on groups (n = 7) of uninjured rats and on injured rats during Weeks 1 and 2 after SCI (before and after spontaneous voiding was established) as well as Week 2 after a complete transection (n = 3). Under anesthesia, the bladder was continuously perfused with saline. Changes in bladder pressure and external urethral sphincter (EUS) electrical activity were monitored. The bladder was then dissected and weighed and both the bladder and spinal cord were fixed for pathoanatomical analyses. Our results indicate that several aspects of LUT dysfunction after contusive SCI were similar to transection, e.g., reduction of voiding efficiency (approximately 5% of normal value), decrease in inter-contraction interval (47%), increase in bladder capacity (8-fold), and weight (4.6-fold). One aspect appeared different from transection--partial recovery from acute bladder/sphincter dyssynergia. Because the coordination of bladder and EUS function is mediated by brainstem pathways, partial recovery of synergy after SCI was likely due to sparing of some relevant bulbospinal projections as was confirmed by retrograde transneuronal viral tracing. 相似文献
92.
93.
Jasmin Tremblay 《电子产品世界》2006,(12):83-86
推动对经济型高密度千兆以太网交换机需求不断增长的因素有多方面,如从快速以太网到千兆以太网标准的演进、新的高带宽应用,以及稳步上升的网络业务交易规模及数量。本文将对推动千兆以太网交换机密度和性能提高的应用及趋势作一个全面的评述。 相似文献
94.
Svetlana Karakhanova Beate Mosl Sabine Harig Katharina von Ahn Jasmin Fritz Jan Schmidt Dirk J?ger Jens Werner Alexandr V. Bazhin 《International journal of molecular sciences》2014,15(3):4104-4125
Prognosis of patients with carcinoma of the exocrine pancreas is particularly poor. A combination of chemotherapy with immunotherapy could be an option for treatment of pancreatic cancer. The aim of this study was to perform an immunomonitoring of 17 patients with pancreatic cancer from the CapRI-2 study, and tumor-bearing mice treated with combination of chemo (radio) therapies with interferon-2α. Low doses of interferon-2α led to a decrease in total leukocyte and an increase in monocyte counts. Furthermore, we observed a positive effect of interferon-2α therapy on the dendritic cells and NK (natural killer) cell activation immediately after the first injection. In addition, we recorded an increased amount of interferon-γ and IL-10 in the serum following the interferon-2α therapy. These data clearly demonstrate that pancreatic carcinoma patients also show an immunomodulatory response to interferon-2α therapy. Analysis of immunosuppressive cells in the Panc02 orthotopic mouse model of pancreatic cancer revealed an accumulation of the myeloid-derived suppressor cells in spleens and tumors of the mice treated with interferon-2α and 5-fluorouracil. The direct effect of the drugs on myeloid-derived suppressor cells was also registered in vitro. These data expose the importance of immunosuppressive mechanisms induced by combined chemo-immunotherapy. 相似文献
95.
Quasi‐epitaxial Growth of [Ru(bpy)3]2+ by Confinement in Clay Nanoplatelets Yields Polarized Emission
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96.
R Gioia J Li J Schuster Y Zhang G Zhang X Li B Spiro RS Bhatia J Dachs KC Jones 《Environmental science & technology》2012,46(18):10012-10021
Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) are reported in 97 air samples collected on board the RV Polarstern in November 2007 from the equator to Cape Town, South Africa and the MV Oceanic II (The Scholar Ship) in January-March 2008 from Shanghai, China to Cape Verde in the Central Atlantic Ocean. The atmospheric concentrations were higher close to the coast and lower in remote regions of the Indian and South Atlantic Ocean. Groups of samples were selected in the South China Sea, Indian Ocean and South Atlantic Ocean where the relative wind direction matched the trajectory of the ship, thus all the samples had the same input of sources upwind. In these three regions the concentrations of OCPs and PCBs declined during atmospheric transport following first order kinetics. These sets of measurements provided estimates of field derived residence times (FDRTs) for individual compounds. These values were compared with predicted atmospheric residence times (PARTs) computed using a model of long-range atmospheric transport potential of POPs. The FDRTs are 5-10 times longer for the more volatile PCB congeners and TC, CC, p,p'-DDT and p,p'-DDE than the respective PARTs, while they are similar to PARTs for the less volatile compounds. Possible causes of discrepancies between PARTs and FDRTs are discussed, and revolatilization from the ocean surface seems to be the main cause for the higher values of FDRTs of the more volatile compounds in comparison with the respective PARTs. 相似文献
97.
98.
Janine J. Wilden Jasmin C. Jacob Christina Ehrhardt Stephan Ludwig Yvonne Boergeling 《International journal of molecular sciences》2021,22(11)
Influenza virus is a well-known respiratory pathogen, which still leads to many severe pulmonary infections in the human population every year. Morbidity and mortality rates are further increased if virus infection coincides with co-infections or superinfections caused by bacteria such as Streptococcus pneumoniae (S. pneumoniae) and Staphylococcus aureus (S. aureus). This enhanced pathogenicity is due to complex interactions between the different pathogens and the host and its immune system and is mainly governed by altered intracellular signaling processes. In this review, we summarize the recent findings regarding the innate and adaptive immune responses during co-infection with influenza virus and S. pneumoniae or S. aureus, describing the signaling pathways involved and how these interactions influence disease outcomes. 相似文献
99.
Iris E. Eder Martina Egger Hannes Neuwirt Christof Seifarth Danilo Maddalo Andreas Desiniotis Georg Sch?fer Martin Puhr Jasmin Bektic Andrew C. B. Cato Helmut Klocker 《International journal of molecular sciences》2013,14(6):11942-11962
Progression to castration resistance is a major problem in the treatment of advanced prostate cancer and is likely to be driven by activation of several molecular pathways, including androgen receptor (AR) and cyclic AMP-dependent protein kinase A (PKA). In this study, we examined the therapeutic efficacy of a combined inhibition of the AR and the regulatory subunit type Iα (RIα) of protein kinase A with second generation antisense oligonucleotides (ODNs) in androgen-sensitive LNCaP and castration-resistant LNCaPabl tumors in vivo. We found that targeting the AR alone inhibited LNCaP, as well as LNCaPabl tumors. Combined inhibition resulted in an improved response over single targeting and even a complete tumor remission in LNCaPabl. Western blot analysis revealed that both ODNs were effective in reducing their target proteins when administered alone or in combination. In addition, treatment with the ODNs was associated with an induction of apoptosis. Our data suggest that dual targeting of the AR and PKARIα is more effective in inhibiting LNCaP and LNCaPabl tumor growth than single treatment and may give a treatment benefit, especially in castration-resistant prostate cancers. 相似文献
100.
Abbas H. K. Al Temimi Dr. Michael Martin Dr. Qingxi Meng Danny C. Lenstra Dr. Ping Qian Prof. Dr. Hong Guo Prof. Dr. Elmar Weinhold Prof. Dr. Jasmin Mecinović 《Chembiochem : a European journal of chemical biology》2020,21(3):392-400
Biomedicinally important histone lysine methyltransferases (KMTs) catalyze the transfer of a methyl group from S-adenosylmethionine (AdoMet) cosubstrate to lysine residues in histones and other proteins. Herein, experimental and computational investigations on human KMT-catalyzed ethylation of histone peptides by using S-adenosylethionine (AdoEth) and Se-adenosylselenoethionine (AdoSeEth) cosubstrates are reported. MALDI-TOF MS experiments reveal that, unlike monomethyltransferases SETD7 and SETD8, methyltransferases G9a and G9a-like protein (GLP) do have the capacity to ethylate lysine residues in histone peptides, and that cosubstrates follow the efficiency trend AdoMet>AdoSeEth>AdoEth. G9a and GLP can also catalyze AdoSeEth-mediated ethylation of ornithine and produce histone peptides bearing lysine residues with different alkyl groups, such as H3K9meet and H3K9me2et. Molecular dynamics and free energy simulations based on quantum mechanics/molecular mechanics potential supported the experimental findings by providing an insight into the geometry and energetics of the enzymatic methyl/ethyl transfer process. 相似文献