Effect of gypsum on free and restrained shrinkage behaviour of slag-concretes subjected to various curing conditions

The effect of gypsum in slag-blended cement on free and restrained shrinkage of concrete subjected to various curing conditions is presented in this paper. Added gypsum in slag-blended cements was found to increase the autogenous shrinkage of concrete up to 56 days. However, added gypsum caused small reduction in the long-term shrinkage when the concrete was exposed to drying. Slag concretes with 3% added gypsum content, when exposed to drying at the age of 24 h, exhibited more cracking tendency than comparable concrete with 0% added gypsum. This is attributed to the increased shrinkage evolution of slag concrete with 3% gypsum content at early ages. However, if moist cured for 7 days, increasing the amount of gypsum from 3 to 5% in slag-blended cement reduced the cracking tendency. It is concluded that the beneficial effect of increasing gypsum in reducing cracking tendency in slag concrete is only favourable if moist cured for 7 days.     

DIDS: rapidly prototyping configuration design systems

The domain independent design system (DIDS) provides a set of tools for rapidly constructing new configuration design systems from a library of reusable software elements called mechanisms. A DIDS user begins by creating a model of the problem domain and the task to be automated. This includes describing a library of parts from which new artifacts could be configured, optimization and preference criteria, and functionality constraints. DIDS analyzes this input and automatically builds an operational prototype system by selecting and combining mechanisms. DIDS' ability to automate this process is derived from its model of configuration design, which enables reusable mechanisms to be identified and automatically selected based on a problem's characteristics. The use of DIDS is illustrated by showing how DIDS solved an elevator-configuration problem.     

Applying Genetic Algorithm and Neural Network to the Conjunctive Use of Surface and Subsurface Water

The conjunctive use of surface and subsurface water is one of the most effective ways to increase water supply reliability with minimal cost and environmental impact. This study presents a novel stepwise optimization model for optimizing the conjunctive use of surface and subsurface water resource management. At each time step, the proposed model decomposes the nonlinear conjunctive use problem into a linear surface water allocation sub-problem and a nonlinear groundwater simulation sub-problem. Instead of using a nonlinear algorithm to solve the entire problem, this decomposition approach integrates a linear algorithm with greater computational efficiency. Specifically, this study proposes a hybrid approach consisting of Genetic Algorithm (GA), Artificial Neural Network (ANN), and Linear Programming (LP) to solve the decomposed two-level problem. The top level uses GA to determine the optimal pumping rates and link the lower level sub-problem, while LP determines the optimal surface water allocation, and ANN performs the groundwater simulation. Because the optimization computation requires many groundwater simulations, the ANN instead of traditional numerical simulation greatly reduces the computational burden. The high computing performance of both LP and ANN significantly increase the computational efficiency of entire model. This study examines four case studies to determine the supply efficiencies under different operation models. Unlike the high interaction between climate conditions and surface water resource, groundwater resources are more stable than the surface water resources for water supply. First, results indicate that adding an groundwater system whose supply productivity is just 8.67 % of the entire water requirement with a surface water supply first (SWSF) policy can significantly decrease the shortage index (SI) from 2.93 to 1.54. Second, the proposed model provides a more efficient conjunctive use policy than the SWSF policy, achieving further decrease from 1.54 to 1.13 or 0.79, depending on the groundwater rule curves. Finally, because of the usage of the hybrid framework, GA, LP, and ANN, the computational efficiency of proposed model is higher than other models with a purebred architecture or traditional groundwater numerical simulations. Therefore, the proposed model can be used to solve complicated large field problems. The proposed model is a valuable tool for conjunctive use operation planning.     

DOT1L Methyltransferase Regulates Calcium Influx in Erythroid Progenitor Cells in Response to Erythropoietin

Erythropoietin (EPO) signaling plays a vital role in erythropoiesis by regulating proliferation and lineage-specific differentiation of murine hematopoietic progenitor cells (HPCs). An important downstream response of EPO signaling is calcium (Ca²⁺) influx, which is regulated by transient receptor potential channel (TRPC) proteins, particularly TRPC2 and TRPC6. While EPO induces Ca²⁺ influx through TRPC2, TRPC6 inhibits the function of TRPC2. Thus, interactions between TRPC2 and TRPC6 regulate the rate of Ca²⁺ influx in EPO-induced erythropoiesis. In this study, we observed that the expression of TRPC6 in KIT-positive erythroid progenitor cells was regulated by DOT1L. DOT1L is a methyltransferase that plays an important role in many biological processes during embryonic development including early erythropoiesis. We previously reported that Dot1l knockout (Dot1l^KO) HPCs in the yolk sac failed to develop properly, which resulted in lethal anemia. In this study, we detected a marked downregulation of Trpc6 gene expression in Dot1l^KO progenitor cells in the yolk sac compared to the wild type (WT). The promoter and the proximal regions of the Trpc6 gene locus exhibited an enrichment of H3K79 methylation, which is mediated solely by DOT1L. However, the expression of Trpc2, the positive regulator of Ca²⁺ influx, remained unchanged, resulting in an increased TRPC2/TRPC6 ratio. As the loss of DOT1L decreased TRPC6, which inhibited Ca²⁺ influx by TRPC2, Dot1l^KO HPCs in the yolk sac exhibited accelerated and sustained elevated levels of Ca²⁺ influx. Such heightened Ca²⁺ levels might have detrimental effects on the growth and proliferation of HPCs in response to EPO.     

A water coverage extraction approach to track inundation in the Saskatchewan River Delta,Canada

Tracking surface water coverage changes is a complicated task for many regions of the world. It is, however, essential to monitor the associated biological changes and bioproductivity. We present a methodology to track contemporary water coverage changes using optical remote sensing and use it to estimate historical summer water coverage in a large river delta. We used a geographical information system automated routine, based on the modified normalized difference water index, to extract the surface water coverage area (SWCA) from optical satellite data sets using the surface water extraction coverage area tool (SWECAT). It was applied to measure SWCA during drought and flood peaks in the Saskatchewan River Delta in Canada, from Landsat, SPOT and RapidEye images. Landsat results compared favourably with Canadian National Hydro Network (CNHN) GeoBase data, with deviations between SWCA classifications and the base CNHN GeoBase shapefile of ~2%. Difference levels between the extracted SWCA layer from Landsat and the higher resolution commercial satellites (SPOT and RapidEye) were also less than 2%. SWCA was tightly linked to discharge and level measurements from in-channel gauges (r² > 0.70). Using the SWCA versus discharge relationship for the gauge with the longest record, we show that peak summer SWCA has declined by half over the last century, from 13% of our study area to 6%, with likely implications for fish and wildlife production.     

Haptic feedback and control of a flexible surgical endoscopic robot

A flexible endoscope could reach the potential surgical site via a single small incision on the patient or even through natural orifices, making it a very promising platform for surgical procedures. However, endoscopic surgery has strict spatial constraints on both tool-channel size and surgical site volume. It is therefore very challenging to deploy and control dexterous robotic instruments to conduct surgical procedures endoscopically. Pioneering endoscopic surgical robots have already been introduced, but the performance is limited by the flexible neck of the robot that passes through the endoscope tool channel. In this article we present a series of new developments to improve the performance of the robot: a force transmission model to address flexibility, elongation study for precise position control, and tissue property modeling for haptic feedback. Validation experiment results are presented for each sector. An integrated control architecture of the robot system is given in the end.     

Impulsivity as a mediating mechanism between early-life adversity and addiction: Theoretical comment on Lovic et al. (2011).

Early-life adversity, impulsivity, and dopaminergic function have all been implicated in adult drug addiction. The article by Lovic, Keen, Fletcher, and Fleming in this issue further elucidates this relationship by demonstrating that early-life adversity can increase impulsivity and decrease behavioral flexibility in adulthood. Recent literature suggests that these results are likely due to structural and functional changes in regions such as the orbitofrontal cortex (OFC) and nucleus accumbens (NAc), as well as altered dopamine activity. Impulsivity and behavioral inflexibility can increase susceptibility to addiction, and in turn, chronic substance abuse can impair the neurocircuitry underlying behavioral inhibition. Thus, early-life adversity may act as an entry point into a feed-forward spiral of impulsivity and addiction via the dysfunction of regions such as the OFC, NAc, and mesolimbic dopamine. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

High-sensitivity and wide-directivity ultrasound detection using high Q polymer microring resonators

Small size ultrahigh Q polymer microrings working at near visible wavelength have been experimentally demonstrated as ultralow noise ultrasound detectors with wide directivity at high frequencies (>20 MHz). By combining a resist reflow and a low bias continuous etching and passivation process in mold fabrication, imprinted polymer microrings with drastically improved sidewall smoothness were obtained. An ultralow noise-equivalent pressure of 21.4 Pa over 1-75 MHz range has been achieved using a fabricated detector of 60 μm diameter. The device's wide acceptance angle with high sensitivity considerably benefits ultrasound-related imaging.