Analysis of switched quantizer based on the quadratic spline functions

In this paper, an approximation of the optimal compressor function using the quadratic spline functions with 2L?=?8 segments is described. Since the quadratic spline with 2L?=?8 segments provides better approximation of the optimal compression function than quadratic spline with 2L?=?4 segments, capitalizing on the benefits of the obtained spline approximation, quantizer designing process is firstly performed for the so assumed number of segments and the Laplacian source of a unit variance. Then, to enhance the usability of the proposed model, the switched quantization technique is applied and a beneficial analysis is derived, providing insight in the robustness of the proposed quantizer performances with respect to the mismatch in designed for and applied to variances. Reached quality has been compared to another model from the literature, and it has been shown that the proposed model outperforms the previous model by almost 1.3?dB.     

An Overview,Advantages and Therapeutic Potential of Nonpeptide Positive Allosteric Modulators of Glucagon-Like Peptide-1 Receptor

Due to uncomfortable injection regimens of peptidic agonists of glucagon-like peptide-1 receptor (GLP-1R), orally available nonpeptide positive allosteric modulators (PAMs) of GLP-1Rs are foreseen as the possible future mainstream therapy for type 2 diabetes. Herein, current GLP-1R PAMs are reviewed. Based on the effectiveness and in silico predicted physicochemical properties, pharmacokinetics, and toxicity, possible candidates for further development as oral drugs were selected. The suggestion is that GLP-1R PAMs might be used orally alone or in combination with dipeptidyl peptidase-4 (DPP-4) inhibitors, which could offer an optimal treatment option next to metformin monotherapy in type 2 diabetes mellitus, or in a wider spectrum of indications. Quercetin acts as a GLP-1R PAM and DPP-4 inhibitor, and therefore, might be considered as a pioneering agent with a dual mechanism of action, in terms of GLP-1R positive allosteric modulation and DPP-4 inhibition for potentiating GLP-1 dependent effects.     

Guest editorial for EMMSAD’2020 special section

Software and Systems Modeling -     

The influence of spiral jet-milling on the physicochemical properties of carbamazepine form III crystals: Quality by design approach

The purpose of this study was to investigate the influence of spiral jet-milling process on the physicochemical characteristics of α polymorphic active pharmaceutical ingredient, using Carbamazepine form III as a model drug, and taking into consideration Quality by Design (QbD) approach to pharmaceutical development. A 2^(4-1) factorial screening design was implemented to identify the spiral jet-milling process variables that significantly affect the particle size distribution of milled samples. Diameter of injector nozzles, diameter of ring nozzles and air pressure were selected for further analysis using a 2^(3-1) factorial experimental design. Particle size distribution of additional samples was determined, while physicochemical properties were examined by differential scanning calorimetry (DSC), hot-stage polarized microscopy (HSPM), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and compared to those of un-milled drug. The gathered results shown that applied experimental design approach is capable to predict material behavior and could help in better understanding of material behavior during jet-milling process. Created design space (DS) provides assurance of product quality, expressed as the powder particle sizes lower than 5 μm, as well as, in initial polymorph form existence after jet-milling through combination and interaction of input variables.     

Effect of supercritical CO2 extraction process parameters on oil yield and pigment content from by‐product hemp cake

This research gives an insight into the possibility of exploiting the one of the food industry's by‐products – pressed hemp cake. The complete recovery of oil from pressed hemp cake was achieved. Residual oil that remained in cake after pressing was extracted with supercritical CO₂ by applying different process parameters. Optimal extraction conditions were determined using response surface methodology. Total pigment contents of the oils obtained were determined. Extraction pressure had the most significant influence on yield and pigment content of extracted hemp cake oil. Depending on the pressure, the chlorophyll a content ranged from 101.11 to 378.28 mg kg^?1 and chlorophyll b from 65.14 to 189.78 mg kg^?1, while total carotene content was in the range from 33.58 to 132.67 mg kg^?1. The remaining oil in pressed hemp cake after supercritical CO₂ extraction was determined to be 0.56 ± 0.08% and the defatted cake was rich in proteins and fibre.     

Aerodynamic design and analysis of a small-scale vertical axis wind turbine

Small-scale vertical axis wind turbines are regarded today as an attractive source of green energy, still insufficiently implemented and tested. This paper presents a fast design methodology of such a VAWT, in terms of choosing its main parameters: airfoil, rotor diameter and solidity. For obtaining generated power of each considered geometrical model at different undisturbed wind velocities and rotor angular velocities two models were used — momentum and vortex-wake model, combined with experimentally measured airfoil data (airfoil lift and drag coefficients). Even though the former model is simpler, it is the most utilized model, known to provide good results in stationary working regimes. Both models still present fairly accurate and fast tools for computation and optimization, particularly useful in the phase of conceptual design. In this research, the use of the momentum model resulted in determination of the maximal power coefficient, optimal- and minimal freestream velocity for every considered VAWT model. From these output parameters, a selection of the optimal geometric model was done, and a more detailed transient analysis and flow representation around the selected solution was obtained by the vortex-wake model. The results obtained by the two used computational models coincide satisfactorily.     

Outage performance of dual‐hop relaying systems over extended generalized‐K fading channels

The outage performance of the amplify‐and‐forward relaying strategies over mutually uncorrelated extended generalized‐K fading channels is addressed in this paper. The attention is dedicated to the analyses of the noise‐limited and also interference‐limited environment. The new analytical expression for outage probability of observed relaying system in the presence of thermal noise is derived using the method for approximating equivalent signal‐to‐noise ratio. In addition, the outage performance is studied for the dual‐hop system when only the single dominant co‐channel interference is inherent at the relay and destination node. The correctness of the proposed mathematical derivations is verified by simulations. Copyright © 2014 John Wiley & Sons, Ltd.     

Simultaneous oxidation of aromatic compounds using Sr-doped lanthanum manganites as catalysts

Strontium-doped lanthanum manganites, La_1-xSr_xMnO₃ (LSMO), are promising and affordable catalysts for oxidative degradation of volatile organic compounds. LSMO catalysts (x = 0, .1, .2, and .3) were prepared by the citrate-nitrate autocombustion (CNA) and coprecipitation synthesis. The phase composition was confirmed by X-ray diffraction and Rietveld refinement analysis, while the oxygen content was determined by Mohr's salt permanganate titration. Morphology and porosity of prepared catalysts was correlated to catalytic oxidation of benzene, toluene, ethylbenzene and o-xylene. It was observed that both synthesis methods yielded catalysts of similar average pore size diameter and specific surface area, but the pore size distribution differed: CNA-prepared catalysts had a multimodal pore size distribution, while the coprecipitated ones had a single maximum at 4 nm. Catalysts prepared by the CNA method have shown a higher catalytic activity in the temperature range 373–723 K, as the presence of Mn³⁺/Mn⁴⁺ mixed valences increased their reducibility.