Summary
This article reports the synthesis of novel hydrophilic end-branched poly(ethylene glycol)s, in aqueous media by atom transfer
radical polymerization (ATRP). Poly(ethylene glycol)s with molecular weights 10,000 and 16,000 were end-functionalized and
used as bifunctional initiators for the polymerization of a poly(ethylene glycol) macromonomer with a molecular weight of
2,000 (PEGMA), either by aqueous ATRP or in a watedmethanol (l/l V/V) mixture. For both macroinitiators a DP of 10 was the
target, giving an average of 5 branches in each end. The rates of polymerization were of the same order of magnitude when
the polymerizations were initiated by either of the two macroinitiators in watedmethanol (l/l V/V). When a bifunctional oligo(ethy1ene
glycol) initiator (Mn = 600) was used to study the polymerization of PEGMA in water/methanol a reduction in the rate of polymerization was observed
indicating an influence of the molecular weight of the initiator on the rate of polymerization.
Received 25 Maich 2002/Revised 8 November 2002/Accepted 8 November 2002
Correspondence to Jorgen Kops 相似文献
The hydroisomerization of two long-chain n-alkane mixtures was investigated over bifunctional Pt/H-ZSM-5 catalysts before and after dealumination of preshaped zeolite/binder pellets. The hydroisomerization over the dealuminated catalysts leads to more isomers and less cracking products. Consequently, higher ratios of multi- to mono-branched isomerization products are formed as expected for large- rather than medium-pore zeolites. This indicates a higher availability of space in the vicinity of the active sites and provides an attractive route to make medium-pore zeolites suitable for upgrading higher boiling hydrocarbon feeds. 相似文献
This article investigates the prediction of the crack growth angle of an existing internal crack under mixed mode loading at the crack tip for an unfilled ethylene propylene diene terpolymer rubber (EPDM). For the realization of mixed mode loading, the cracks of the uniaxial loaded specimens were oriented with different angles to the loading direction. The energy density factor was used as a potential criterion for determining the crack growth angle. The determination of the strain energy density factor was carried out simulatively in Abaqus. The second-order Ogden model was used to describe the rubber-like material behavior. The relative local minimum of the strain energy density factor provides the possible growth angle. The experimental investigations show that the initial cracks grow orthogonally to the loading direction for the different crack orientation angles. For the crack orientation angle parallel to the load direction, the crack growth was observed because the strong stretching of the specimen caused strong necking in the crack region. The crack growth for the remaining crack orientation angles were induced due to shear loading at the crack tip. The predictive angle of different crack orientation angles shows very good accordance to the measured crack growth angles. 相似文献
This paper explores how different forms of anticipatory work contribute to reliability in high-risk space operations. It is based on ethnographic field work, participant observation and interviews supplemented with video recordings from a control room responsible for operating a microgravity greenhouse at the International Space Station (ISS). Drawing on examples from different stages of a biological experiment on the ISS, we demonstrate how engineers, researchers and technicians work to anticipate and proactively mitigate possible problems. Space research is expensive and risky. The experiments are planned over the course of many years by a globally distributed network of organizations. Owing to the inaccessibility of the ISS, every trivial detail that could possibly cause a problem is subject to scrutiny. We discuss what we label anticipatory work: practices constituted of an entanglement of cognitive, social and technical elements involved in anticipating and proactively mitigating everything that might go wrong. We show how the nature of anticipatory work changes between planning and the operational phases of an experiment. In the planning phase, operators inscribe their anticipation into technology and procedures. In the operational phase, we show how troubleshooting involves the ability to look ahead in the evolving temporal trajectory of the ISS operations and to juggle pre-planned fixes along these trajectories. A key objective of this paper is to illustrate how anticipation is shared between humans and different forms of technology. Moreover, it illustrates the importance of including considerations of temporality in safety and reliability research. 相似文献
“Simply, people can no longer remember passwords good enough to reliably defend against dictionary attacks, and are much more secure if they choose a password too complicated to remember and then write it down. We’re all good at securing small pieces of paper. I recommend that people write their passwords down on a small piece of paper, and keep it with their other valuable small pieces of paper: in their wallet.” 相似文献
To improve the tarnished reputation of WLAN security, the new IEEE 802.11i standard provides means for mutual user authentication and assures confidentiality of user data. However, the IEEE 802.11 link-layer is still highly vulnerable to a plethora of simple, yet effective attacks which further jeopardize the already fragile security of wireless communications.Some of these vulnerabilities are related to limited hardware capabilities of access points and their abuse may result in serious degradation of control over the wireless connection, which, especially in the case of broadcast communication, allows for client hijacking attacks. Although these issues are known and their impact is expected to be less prevalent on modern equipment, this work demonstrates the opposite. In our experimental analysis, we tested frequently used access points, and by forcing them to operate on their performance limits, we identified significant operational anomalies and demonstrated their impact on security by implementing a novel version of the Man-In-The-Middle attack, to which we refer as the Muzzle attack.Secondly, this work describes DiscoSec, a solution for “patching” WLANs against a variety of such link-layer attacks. DiscoSec provides DoS-resilient key exchange, an efficient frame authentication, and a performance-oriented implementation. By means of extensive real-world measurements DiscoSec is evaluated, showing that even on very resource-limited devices the network throughput is decreased by only 22% compared to the throughput without any authentication, and by 6% on more performance-capable hardware. To demonstrate its effectiveness, DiscoSec is available as an open-source IEEE 802.11 device driver utilizing well-established cryptographic primitives provided by the Linux Crypto API and OpenSSL library. 相似文献
A nonlinear observer for estimation of the longitudinal velocity, lateral velocity, and yaw rate of a vehicle, designed for the purpose of vehicle side-slip estimation, is modified and extended in order to work for different road surface conditions. The observer relies on a road-tire friction model and is therefore sensitive to changes in the adhesion characteristics of the road surface. The friction model is parametrized with a single friction parameter, and an update law is designed. The adaptive observer is proven to be uniformly globally asymptotically stable and uniformly locally exponentially stable under a persistency-of-excitation condition and a set of technical assumptions, using results related to Matrosov's theorem. The observer is tested on recorded data from two test vehicles and shows good results on a range of road surfaces. 相似文献
Optimization problems in software engineering typically deal with structures as they occur in the design and maintenance of software systems. In model-driven optimization (MDO), domain-specific models are used to represent these structures while evolutionary algorithms are often used to solve optimization problems. However, designing appropriate models and evolutionary algorithms to represent and evolve structures is not always straightforward. Domain experts often need deep knowledge of how to configure an evolutionary algorithm. This makes the use of model-driven meta-heuristic search difficult and expensive. We present a graph-based framework for MDO that identifies and clarifies core concepts and relies on mutation operators to specify evolutionary change. This framework is intended to help domain experts develop and study evolutionary algorithms based on domain-specific models and operators. In addition, it can help in clarifying the critical factors for conducting reproducible experiments in MDO. Based on the framework, we are able to take a first step toward identifying and studying important properties of evolutionary operators in the context of MDO. As a showcase, we investigate the impact of soundness and completeness at the level of mutation operator sets on the effectiveness and efficiency of evolutionary algorithms.
Introduction: Low‐grade chronic inflammation is common in hemodialysis (HD) patients. Previous studies suggest an anti‐inflammatory effect of angiotensin II receptor blocker (ARB) treatment. The aim of this study was to compare the effect of ARB vs. placebo on plasma concentrations of inflammatory markers in HD patients. Methods: Adult HD patients were randomized for double‐blind treatment with the ARB irbesartan 150–300 mg/day or placebo. At baseline, 1 week, 3, 6, 9, and 12 months plasma high sensitivity C‐reactive protein (hsCRP), interleukin (IL)?1β, IL‐6, IL‐8, IL‐18, and transforming growth factor‐β (TGF‐β) were measured using Luminex and enzyme‐linked immunosorbent assay (ELISA) technology. Findings: Eighty‐two patients were randomized (placebo/ARB: 41/41). The groups did not differ in initial levels of any of the inflammatory markers (placebo/ARB median(range)): hsCRP 3.3(0.2–23.4)/2.7(0.2–29.6) μg/mL; IL‐1β 1.1(0.0–45.9)/1.1(0.0‐7.2) pg/mL; IL‐6 10(1–90)/12(1–84) pg/mL; IL‐8 31(9–134)/34(5–192) pg/mL; IL‐18 364(188–1343)/377(213–832) pg/mL; TGF‐β 3.2(0.8–13.9)/3.6(1.3–3.8) ng/mL. Overall, there was no significant difference in hsCRP, IL‐6, IL‐8, and TGF‐β between placebo and ARB‐treated patients during the study period, and hsCRP, IL‐6, IL‐8, and TGF‐β were relatively stable during the study period (P ≥ 0.18 in all tests for parallel curves, equal levels, and constant levels). The IL‐1β level was slightly different in the two groups over time, but not significantly (P = 0.09 in test for parallel curves) and it was also relatively stable during the study period (P ≥ 0.49 in tests for equal levels and constant level). IL‐18 was the only inflammatory marker which was not constant during the study period (P = 0.001 in test for constant level), but there was no significant difference between placebo and ARB‐treated (P ≥ 0.51 in tests for parallel curves and equal levels). Discussion: Inflammatory biomarkers were neither acutely, nor in the long‐term significantly affected by the ARB irbesartan. Our findings suggest that ARB treatment in HD patients does not offer protective anti‐inflammatory effects. 相似文献